Bupleurum Chai Hu vs Thorowax

A fundamental TCM herb that harmonizes Shao Yang patterns; saikosaponins modulate immune function and protect the liver; major herb in Xiao Chai Hu Tang formula.

Japanese Kampo and TCM herb used for liver conditions, alternating fever and chills, and immune modulation; component of Sho-saiko-to formula.

Saikosaponins, Rutin, Isoquercitrin, Phytosterols

saikosaponin A, saikosaponin C, saikosaponin D, rutin, quercetin

Liver qi stagnation and alternating chills and fever, Liver protection and anti-hepatitis, Menstrual irregularities from liver qi stagnation

Liver conditions, Alternating fever chills, Immune modulation, Inflammatory conditions

Hepatoprotective and anti-liver fibrosis, Immune modulation, Anti-inflammatory

Hepatoprotective effects, Immunomodulatory activity, Anti-inflammatory properties, Anticancer potential

3-9g decoction or 300-500mg standardized extract twice daily

3-9g dried root daily; 500mg extract twice daily

Avoid in liver failure, Use caution with immunosuppressants

Pregnancy, Long-term use caution, Interstitial pneumonia concern in Kampo

GI disturbance, Rare hepatotoxicity (Long-term high dose)

Interstitial pneumonia (rare in Kampo context), GI effects