Diphylleia grayi vs Kratom

Side-by-side comparison of medicinal herbs

Herb

Diphylleia grayi

Analgesic

Mitragyna speciosa

Analgesic

Diphylleia grayi

❌ Not recommended in pregnancy

❌ Not recommended while nursing

Kratom

❌ Not recommended in pregnancy

❌ Not recommended while nursing

Description

Japanese alpine plant; flowers turn translucent when wet; used in Japanese folk medicine for pain relief.

A Southeast Asian tree whose leaves have dose-dependent stimulant and opioid-like effects. Controversial and regulated.

Active Compounds

podophyllotoxin derivatives, flavonoids, alkaloids

Mitragynine, 7-hydroxymitragynine, Speciociliatine, Paynantheine

Traditional Uses

pain relief, rheumatism, anti-tumor (research)

Pain relief, Energy at low doses, Opium withdrawal aid

Modern Uses

topical analgesic (limited use)

Opioid receptor activity, Pain management research, Addiction withdrawal studies

Adult Dosage

Limited use only; potential toxicity

Highly variable; 1-5g powder (stimulant), 5-15g (sedative). Consult healthcare provider.

Contraindications

internal use, pregnancy

Liver disease, Heart conditions, Pregnancy, Psychiatric conditions, Opioid medications

Side Effects

potential toxicity if ingested

Nausea, Constipation, Dependence, Liver toxicity, Seizures

Drug Interactions

0 known interactions

Reviewed by: HerbAlly Editorial Team, Medical herbalists and healthcare professionals

Sources: WHO Monographs · NCCIH · PubMed · Commission E