Germander vs Milk Thistle

A European herb once popular for gout and weight loss, now known to cause hepatotoxicity — a cautionary tale.

Milk thistle has been used for over 2,000 years as a natural remedy for liver and gallbladder disorders. Its active compound complex, silymarin, has been extensively studied for hepatoprotective effects. It is one of the few herbs with strong clinical evidence for liver support and protection.

Neoclerodane diterpenes, Teucrins, Flavonoids, Tannins

Silymarin, Silibinin, Silychristin, Silydianin, Isosilybinin

Gout, Fever, Weight loss, Digestive aid

Liver protection, Gallbladder support, Antidote for mushroom poisoning, Digestive aid, Blood sugar regulation

WITHDRAWN from use in many countries due to hepatotoxicity

Liver disease support (hepatitis, cirrhosis, fatty liver), Liver detoxification, Mushroom poisoning treatment, Metabolic syndrome, Chemotherapy liver protection

NOT RECOMMENDED — documented hepatotoxicity. Historical use only.

200-400mg silymarin (standardized 70-80%) 2-3 times daily

Liver disease, All use without medical supervision, Pregnancy

Allergy to Asteraceae family, Hormone-sensitive conditions (weak estrogenic effect)

Hepatotoxicity, Liver failure, Hepatitis

GI upset, Diarrhea, Nausea, Bloating, Allergic reactions