Sacred Mushroom Psilocybin vs Hypericum Maculatum

Psychedelic mushroom used in Aztec and Mazatec sacred healing ceremonies for millennia. Now in FDA breakthrough therapy status for depression and PTSD. Legal status varies.

Perennial herb of European meadows closely related to common St John's Wort, used in Central European folk medicine for similar nervous system conditions.

psilocybin, psilocin, baeocystin, norbaeocystin

hypericin, pseudohypericin, hyperforin, flavonoids, xanthones

Sacred Mazatec healing ceremonies, Spiritual medicine and divination, Treat existential distress, Aztec and Maya sacred fungi

mild depression, nervous conditions, wound healing, anxiety, neuralgia

Antidepressant (clinical trials), PTSD treatment research, Addiction treatment research, Mystical experience facilitator

antidepressant, anxiolytic, wound healing, anti-inflammatory

FDA clinical trials only; self-use where legal 1-3g dried mushroom

4–6g dried herb as tea 3x daily or 300mg extract

Personal or family history of psychosis, Severe cardiovascular disease, Pregnancy, Outside clinical context

SSRIs, cyclosporine, contraceptives, pregnancy, photosensitivity

Panic attacks, Psychosis in susceptible, Flashbacks

photosensitivity, serotonin syndrome, drug interactions