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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Acanthopanax sessiliflorus (also known as Eleutherococcus sessiliflorus) is a medicinal herb from Northeast China and Korea used for dietary and therapeutic purposes [PMID:37764339, PMID:41448365, PMID:25324932].
Contexte
A member of the Araliaceae family, this small woody shrub is native to Korea and Northeast China [PMID:37764339, PMID:41448365, PMID:25324932, PMID:26587004].
Usages traditionnels
The root barks are used to dispel wind and dampness, strengthen tendons and bones, promote blood circulation, and remove stasis [PMID:37764339]. The fruits are used traditionally as an analgesic, tonic, antidiabetic, antihypertensive, anti-inflammatory, antitumor, and immune-stimulating agent [PMID:32295006]. It has also been used to strengthen the liver and improve vitality [PMID:41448365].
Composés actifs
Key compounds include 3,4-seco-lupane triterpenes (chiisanoside, divaroside, sessiloside-A, chiisanogenin, and sessiligenin) [PMID:33615691, PMID:33183092, PMID:31460786], eleutherosides (phenylpropanoid and lignan glycosides) [PMID:25005060], bioactive peptides (G-6-Y, P-8-R, and F-10-W) [PMID:41448365, PMID:38389921], phenolic acids (chlorogenic acid, caffeic acid, protocatechuic acid), flavonoids (hyperoside), and anthocyanins [PMID:40222954, PMID:38219632, PMID:32295006, PMID:12135097].
Mécanisme d'action
Mechanisms include activation of the IRS-1/PI3K/Akt signaling pathway to enhance glucose uptake [PMID:40554287], activation of the Dock1/PIP5K1A and SLC7A11/GPX4 pathways to inhibit ferroptosis and cytoskeleton damage [PMID:39505327], and the reduction of reactive oxygen species (ROS) and oxidative stress [PMID:41578724, PMID:38389921].
Preuves cliniques
Preuve DDrug-induced liver injury (APAP)
The natural peptide G-6-Y protects against liver injury by reducing oxidative stress, apoptosis, and inflammatory responses [PMID:41448365]
Preuve DHyperglycemia
Chiisanogenin enhances glucose uptake and lowers postprandial blood glucose levels via insulin signaling activation [PMID:40554287]
Preuve DCisplatin-induced ototoxicity
Chiisanoside protects hair cells by maintaining cytoskeletal homeostasis and inhibiting ferroptosis [PMID:39505327]
Preuve DRheumatoid Arthritis
Extracts containing pimaric and kaurenoic acids attenuated pro-inflammatory cytokine-mediated increase in catabolic factors in vitro [PMID:38167214]
Preuve DSedation/Hypnosis
The water fraction of the root extract prolonged pentobarbital-induced sleeping time in mice [PMID:28049349]
The current evidence is based entirely on in vitro studies and animal models (Level D). There are no human clinical trials or systematic reviews provided.
Sources PubMed
1.PMID: 37764339 (2023) — Phytochemistry and Pharmacology of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S.Y.Hu: A Review. · Molecules (Basel, Switzerland)
2.PMID: 28049349 (2017) — Chemical constituents of Eleutherococcus sessiliflorus extract and its sedative-hypnotic effect. · Natural product research
3.PMID: 41448365 (2026) — From traditional tonic herb to molecular therapy: The natural peptide G-6-Y from Eleutherococcus sessiliflorus protects against drug-induced liver injury. · Journal of ethnopharmacology
4.PMID: 25324932 (2014) — Acanthopanax sessiliflorus stem confers increased resistance to environmental stresses and lifespan extension in Caenorhabditis elegans. · Nutrition research and practice
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Various triterpenoids and stem bark extracts exhibit cytotoxic and antiproliferative activities, inducing apoptosis in HepG2 and breast cancer cells [PMID:33183092, PMID:26587004, PMID:35141205, PMID:31460786]
Preuve DArrhythmia
3,4-seco-lupane triterpenes showed anti-arrhythmic effects in barium chloride-induced rat models [PMID:33615691]
(2021)
— Protective Effects of 3,4-Seco-Lupane Triterpenes from Food Raw Materials of the Leaves of Eleutherococcus Senticosus and Eleutherococcus Sessiliflorus on Arrhythmia Induced by Barium Chloride.
· Chemistry & biodiversity
6.PMID: 25005060 (2014) — Biotechnological production of eleutherosides: current state and perspectives. · Applied microbiology and biotechnology
7.PMID: 28182104 (2017) — Phytoconstituents and Nutritional Properties of the Fruits of Eleutherococcus divaricatus and Eleutherococcus sessiliflorus: A Study of Non-European Species Cultivated in Poland. · Oxidative medicine and cellular longevity
8.PMID: 34572966 (2021) — Noble 3,4-Seco-triterpenoid Glycosides from the Fruits of Acanthopanax sessiliflorus and Their Anti-Neuroinflammatory Effects. · Antioxidants (Basel, Switzerland)
9.PMID: 41578724 (2026) — Comparative metabolomic analysis of Acanthopanax senticosus and Acanthopanax sessiliflorus ripe fruits. · Natural product research
10.PMID: 38710375 (2024) — Triterpenoids from the leaves of Eleutherococcus sessiliflorus, and their antiproliferative activities in TNF-α induced HFLS-RA cells. · Phytochemistry
11.PMID: 34436446 (2021) — NMR-Based Metabolomics Approach to Investigate the Effects of Fruits of Acanthopanax sessiliflorus in a High-Fat Diet Induced Mouse Model. · Metabolites
13.PMID: 38389921 (2024) — Isolation and purification of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu peptides and study of their antioxidant effects and mechanisms. · Frontiers in pharmacology
14.PMID: 38167214 (2024) — Inhibitory effects of Acanthopanax sessiliflorus Harms extract on the etiology of rheumatoid arthritis in a collagen-induced arthritis mouse model. · Arthritis research & therapy
15.PMID: 23903060 (2013) — Immunostimulating effects of extract of Acanthopanax sessiliflorus. · Experimental animals
16.PMID: 40222954 (2025) — Chemical Composition, Antioxidant Activity of Acanthopanax sessiliflorus Leaves Extract. · Chemistry & biodiversity
17.PMID: 35141205 (2021) — Elesesterpenes A-K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus. · Frontiers in chemistry
19.PMID: 32295006 (2020) — Isolation and Identification of Anthocyanin Component in the Fruits of Acanthopanax Sessiliflorus (Rupr. & Maxim.) Seem. by Means of High Speed Counter Current Chromatography and Evaluation of Its Antioxidant Activity. · Molecules (Basel, Switzerland)
20.PMID: 39860265 (2025) — Ultrasound-Assisted Enzymatic Extraction of the Active Components from Acanthopanax sessiliflorus Stem and Bioactivity Comparison with Acanthopanax senticosus. · Molecules (Basel, Switzerland)
21.PMID: 38219632 (2024) — Discovery of bioactive-chemical Q-markers of Acanthopanax sessiliflorus leaves: An integrated strategy of plant metabolomics, fingerprint and spectrum-efficacy relationship research. · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
22.PMID: 37430935 (2022) — Hot-Air Flow Rolling Dry-Blanching Pretreatment Improves the Drying Quality of Acanthopanax sessiliflorus by Increasing the Drying Rate and Inactivating Enzymes. · Foods (Basel, Switzerland)
23.PMID: 39505327 (2024) — Chiisanoside from the Leaves of Acanthopanax sessiliflorus Can Resist Cisplatin-Induced Ototoxicity by Maintaining Cytoskeletal Homeostasis and Inhibiting Ferroptosis. · Journal of agricultural and food chemistry
24.PMID: 33183092 (2022) — Cytotoxic and anti-tumor effects of 3,4-seco-lupane triterpenoids from the leaves of Eleutherococcus sessiliflorus against hepatocellular carcinoma. · Natural product research
25.PMID: 33188566 (2021) — Potential Myocardial Protection of 3,4-seco-Lupane Triterpenoids from Acanthopanax sessiliflorus Leaves. · Chemistry & biodiversity
26.PMID: 26587004 (2015) — The cytotoxic nature of Acanthopanax sessiliflorus stem bark extracts in human breast cancer cells. · Saudi journal of biological sciences
27.PMID: 31460786 (2021) — 3,4-seco-lupane triterpene derivatives with cytotoxic activities from the leaves of Eleutherococcus sessiliflorus. · Natural product research
28.PMID: 37893489 (2023) — Antimicrobial Effects of Edible Mixed Herbal Extracts on Oral Microorganisms: An In Vitro Study. · Medicina (Kaunas, Lithuania)
29.PMID: 12135097 (2002) — Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. · Archives of pharmacal research
30.PMID: 27103988 (2016) — Contrasting genetic patterns between two coexisting Eleutherococcus species in northern China. · Ecology and evolution