Agaricus Blazei (Agaricus blazei Murill): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Agaricus blazei work in the body?

Agaricus blazei contains beta-1,3/1,6-glucans that bind to immune cell receptors, specifically Dectin-1 and CR3, activating macrophages, natural killer cells, and T-lymphocytes. This immune stimulation enhances the body's surveillance and response to abnormal cells. Additional compounds like blazein and ergosterol have demonstrated anti-tumor activity in laboratory models. With the highest beta-glucan content among medicinal mushrooms, Agaricus blazei is particularly valued for immune modulation. Evidence level: C (preliminary human and animal studies).

Does Agaricus blazei interact with medications?

Agaricus blazei may interact with immunosuppressive drugs, potentially reducing their effectiveness due to its immune-stimulating properties. It may also enhance the effects of antidiabetic medications, causing blood sugar to drop too low. Cases of liver enzyme elevation have been reported, so caution is warranted with hepatotoxic medications. Patients on chemotherapy should consult their oncologist, as timing and interactions vary. Always disclose supplementation to healthcare providers. Evidence level: C.

What is the recommended dosage for Agaricus blazei?

The standard adult dosage is 1-3 grams of standardized extract or 3-6 grams of dried mushroom daily, taken with meals to enhance absorption. For general immune support, 1-2 grams of extract is typically sufficient. Standardized extracts with verified beta-glucan content (30-50%) are preferred for consistency. Dosage may vary based on the specific health condition and product concentration. Evidence level: C (based on preliminary studies and traditional use).

Is Agaricus blazei safe during pregnancy and breastfeeding?

Agaricus blazei is considered unsafe during pregnancy and breastfeeding. The mushroom contains agaritine, a compound with potential mutagenic properties, and insufficient safety data exists for pregnant or nursing individuals. Additionally, its immune-modulating effects could theoretically affect fetal development or infant immune systems. Women who are pregnant, planning pregnancy, or breastfeeding should avoid Agaricus blazei supplements entirely and consult a qualified healthcare provider for safe alternatives.

Can Agaricus blazei help with cancer treatment?

Preliminary research suggests Agaricus blazei may complement cancer treatment through immune enhancement and direct anti-tumor effects. Beta-glucans and compounds like blazein have shown anti-proliferative activity in laboratory and animal studies. Small human studies report improved quality of life and immune markers in cancer patients, though large-scale clinical trials are lacking. Agaricus blazei should never replace conventional cancer treatment. Patients interested in complementary use must consult their oncologist. Evidence level: C.

Who should not take Agaricus blazei?

Individuals with autoimmune diseases such as lupus, rheumatoid arthritis, or multiple sclerosis should avoid Agaricus blazei, as its immune-stimulating effects may worsen autoimmune activity. Those with liver disease should use caution due to reported liver enzyme elevation. People with known mushroom allergies may experience allergic reactions including rash, itching, or respiratory symptoms. Common side effects include digestive upset, nausea, and diarrhea. Consult a healthcare provider before use if you have underlying health conditions.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Agaricus blazei Murill (AbM) is an edible medicinal mushroom native to Brazil with documented immunomodulatory, antitumor, and antioxidant properties [PMID:36387602, PMID:38731895].

Contexte

Also known as 'Cogumelo do Sol' in Brazil and 'Himematsutake' in Japan, Agaricus blazei Murill is a basidiomycete brown fungus native to the Brazilian biome and widely cultivated in Japan [PMID:18317543, PMID:24288568].

Usages traditionnels

Traditionally used to treat atherosclerosis, hepatitis, hyperlipidemia, diabetes, dermatitis, and cancer [PMID:18317543]. In traditional Chinese medicine, it is believed to expel wind and cold [PMID:38776247].

Composés actifs

Bioactive substances include polysaccharides (specifically beta-glucans, including beta-1,3-glucan with beta-1,6-glucose residues), lipids (including ergosterol and sterols), proteins, phenolic compounds, and vitamins B, C, and D [PMID:36387602, PMID:23704809].

Mécanisme d'action

The mushroom exerts antitumor effects via modulation of the immune system [PMID:39471924]. Polysaccharides are thought to act through an opsonizing biochemical pathway [PMID:18317543] and can promote the activity of CD8+ T immune cells [PMID:39471924]. Other mechanisms include the inhibition of immune checkpoint molecules and Axl receptors in lung cancer cells [PMID:34436128] and the blocking of the NLRP3 inflammasome assembly to limit inflammation [PMID:38247134].

Preuves cliniques

Preuve CCancer

Clinical trials have been performed on Agaricus blazei Murill Kyowa for anticancer effects [PMID:35910346]. In vitro and in vivo studies show inhibition of prostate cancer cell proliferation and suppression of tumor growth [PMID:18926679].

Preuve DDiabetes

Ethyl acetate extracts showed significant glucose-lowering activity and alpha-glucosidase inhibition in vitro, comparable to metformin [PMID:31993159].

Preuve DImmune System

In vivo studies in mice showed increased serum IgG levels, increased T-cell numbers in the spleen, and elevated phagocytic capability [PMID:17639159].

Preuve DWound Healing

Polysaccharides used in films promoted collagen deposition and repair of epidermis and dermis layers in vivo [PMID:39510455].

Sécurité et effets indésirables

A two-year bioassay in F344 rats showed no remarkable changes in body weight, hematologic parameters, or organ weights, and no increased incidence of tumors [PMID:17707568]. However, concerns have been raised regarding the content of agaritine, a known carcinogen [PMID:18317543].

Synthèse des preuves

The majority of evidence is based on in vitro and in vivo animal models (Level D) and review articles (Level C). There are limited clinical studies available, and the biological pathways are not yet fully elucidated.

Sources PubMed

1.PMID: 36387602 (2022) — Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill. · Current research in food science
2.PMID: 34022313 (2021) — Polysaccharides and extracts from Agaricus brasiliensis Murill - A comprehensive review. · International journal of biological macromolecules
3.PMID: 38731895 (2024) — Anti-Photodamage Effect of Agaricus blazei Murill Polysaccharide on UVB-Damaged HaCaT Cells. · International journal of molecular sciences
4.PMID: 18317543 (2008) — The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems. · Evidence-based complementary and alternative medicine : eCAM
5.PMID: 12708495 (2003) — Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci.

Agaricus Blazei

Sources et citations

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