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FD
Skin and TopicalVérifié
Feuille d'Aloe Vera
Aloe vera
Guérison des plaies et des brûlures à travers les cultures
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 29 articles PubMed · modèle : gemma4:31b
Résumé
Aloe vera is a succulent plant recognized for its diverse health-promoting, skin care, and medicinal properties [PMID:37915246], including anti-inflammatory, antimicrobial, and wound healing activities [PMID:32183224].
Contexte
Aloe vera (Aloe barbadensis Miller) is a perennial succulent plant belonging to the Lily family [PMID:31643946, PMID:31470079]. It is widely used in cosmetology, pharmaceuticals, and as a dietary supplement [PMID:19882025, PMID:26986231].
Usages traditionnels
Traditionally used to treat skin injuries such as burns, cuts, insect bites, and eczemas, as well as digestive problems [PMID:32183224]. In Mexico and other countries, it has been used for anti-inflammatory and cosmetic purposes, with the yellow juice used as a laxative and the mucilaginous gel used for arthritis, gout, acne, dermatitis, burns, and peptic ulcers [PMID:27507917].
Composés actifs
Aloe vera contains over 200 bioactive compounds [PMID:37915246]. Key constituents include polysaccharides (notably acemannan and acetylated mannans) [PMID:31010204, PMID:10624859], anthraquinone derivatives (aloe-emodin, aloin, emodin) [PMID:32183224, PMID:37915246], aloesin [PMID:32183224], phenolic acids, flavonoids, saponins, alkaloids, and terpenoids [PMID:37915246]. It also contains vitamins C and E, zinc, and amino acids [PMID:34206744].
Mécanisme d'action
Aloe vera exhibits anti-oxidative properties by stimulating the secretion of superoxide dismutase and peroxidase [PMID:39458379]. It contains a carboxypeptidase that inactivates bradykinin in vitro and substances that inhibit thromboxane formation in vivo [PMID:31643946]. Its polysaccharides provide immunomodulatory effects [PMID:10624859, PMID:28216559].
Preuves cliniques
Preuve CSkin Wound Healing
Aloe vera plays an important role in promoting wound healing and is used in wound dressings to accelerate regeneration of damaged skin [PMID:33066720, PMID:31209704].
Preuve CBlood Glucose/Diabetes
Clinical studies demonstrate efficacy in reducing blood glucose levels [PMID:37915246].
Preuve CCancer/Melanoma
Bioactive compounds such as aloin and acemannan show potential antineoplastic activity and can induce apoptosis in cancer cells [PMID:37915246, PMID:36297440].
Preuve BDentistry (Pulpotomy)
In a study of 15 primary molars, Aloe vera gel was used as a healing agent in pulpotomy with no reported pain or mobility after one month [PMID:27507917].
Sécurité et effets indésirables
Ingestion is associated with diarrhea, hypokalemia, pseudomelanosis coli, kidney failure, phototoxicity, and hypersensitive reactions [PMID:26986231]. Oral forms have been linked to rare instances of clinically apparent liver injury [PMID:31643946]. Whole leaf extract has shown evidence of carcinogenic activity in rats and is classified by the IARC as a possible human carcinogen (Group 2B) [PMID:26986231].
Synthèse des preuves
The evidence is primarily based on narrative and systematic reviews (Level C), with some in vitro and in vivo data. While traditional and preliminary clinical use is extensive, particularly for wound healing and glucose reduction, larger controlled trials are needed to determine real efficacy [PMID:19882025, PMID:26090436].
Sources PubMed
1.PMID: 32183224 (2020) — Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. · Molecules (Basel, Switzerland)
2.PMID: 37915246 (2024) — Aloe Barbadensis Miller (Aloe Vera). · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
3.PMID: 33066720 (2021) — Aloe vera: A Medicinal Plant Used in Skin Wound Healing. · Tissue engineering. Part B, Reviews
4.PMID: 26986231 (2016) — Aloe vera: A review of toxicity and adverse clinical effects. · Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
8.PMID: 31010204 (2019) — Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review. · Molecules (Basel, Switzerland)
9.PMID: 29999415 (2019) — Biomedical applications of Aloe vera. · Critical reviews in food science and nutrition
10.PMID: 28216559 (2017) — Aloe Vera for Tissue Engineering Applications. · Journal of functional biomaterials
11.PMID: 10178636 (1998) — Ginger: history and use. · Advances in therapy
12.PMID: 37504418 (2023) — Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects. · Gels (Basel, Switzerland)
13.PMID: 31470079 (2019) — Lead bioactive compounds of Aloe vera as potential anticancer agent. · Pharmacological research
14.PMID: 10624859 (1999) — Aloe vera leaf gel: a review update. · Journal of ethnopharmacology
15.PMID: 36702364 (2023) — The absence of genotoxicity of Aloe vera beverages: A review of the literature. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
16.PMID: 26015726 (2015) — Benefits of Aloe vera in dentistry. · Journal of pharmacy & bioallied sciences
17.PMID: 28328276 (2017) — The potential benefits of using aloe vera in stoma patient skin care. · British journal of nursing (Mark Allen Publishing)
18.PMID: 18794775 (2008) — Composition and applications of Aloe vera leaf gel. · Molecules (Basel, Switzerland)
19.PMID: 31456283 (2019) — Aloe vera as an herbal medicine in the treatment of metabolic syndrome: A review. · Phytotherapy research : PTR
20.PMID: 36297440 (2022) — Effects of Carbon Nanomaterials and Aloe vera on Melanomas-Where Are We? Recent Updates. · Pharmaceutics
21.PMID: 27507917 (2010) — Aloe-Vera: A Nature's Gift to Children. · International journal of clinical pediatric dentistry
22.PMID: 9776900 (1998) — Aloe vera: magic or medicine? · Nursing standard (Royal College of Nursing (Great Britain) : 1987)
23.PMID: 31209704 (2019) — Aloe vera (L.) Webb.: Natural Sources of Antioxidants - A Review. · Plant foods for human nutrition (Dordrecht, Netherlands)
24.PMID: 34206744 (2021) — Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds. · Pharmaceutics
25.PMID: 39458379 (2024) — The Effect of Aloe vera on Skin and Its Commensals: Contribution of Acemannan in Curing Acne Caused by Propionibacterium acnes. · Microorganisms
26.PMID: 36870638 (2023) — Thymol encapsulated chitosan-Aloe vera films for antimicrobial infection. · International journal of biological macromolecules
27.PMID: 26090436 (2015) — The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds. · BioMed research international