Anthriscus sylvestris (Anthriscus sylvestris): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Anthriscus sylvestris work as a digestive remedy?

Anthriscus sylvestris contains furocoumarins, flavonoids, and tannins that contribute to its medicinal actions. The herb functions as a mild carminative, helping relieve gas and bloating by relaxing digestive smooth muscle. Its flavonoid content provides antioxidant activity, while tannins offer mild astringent effects on the digestive tract. The diuretic action is attributed to the combined effects of its active compounds on renal function. Evidence level: C (limited clinical data, primarily traditional use).

Does Anthriscus sylvestris interact with any medications?

Anthriscus sylvestris contains furocoumarins, which can cause photosensitivity and may theoretically interact with photosensitizing medications. Concurrent use with drugs that increase sun sensitivity, such as certain antibiotics, diuretics, or retinoids, could enhance photosensitivity reactions. Due to limited research on specific drug interactions, caution is advised when combining with any prescription medications. Patients taking pharmaceutical drugs should consult a healthcare provider before use. Evidence level: C (theoretical based on constituent profile).

What is the recommended dosage for Anthriscus sylvestris?

Traditional use suggests 1-3 grams of dried herb prepared as a tea for digestive complaints. However, this dosage recommendation comes with significant caution due to safety concerns. The herb should only be used by those who can positively identify it and distinguish it from poisonous look-alikes. Due to limited clinical evidence (Level C) and potential toxicity risks, professional guidance is strongly recommended before use.

Is Anthriscus sylvestris safe during pregnancy?

Anthriscus sylvestris is considered unsafe during pregnancy and should be avoided. The presence of furocoumarins poses potential risks to fetal development, and the herb has not been adequately studied for safety in pregnant women. Additionally, the risk of misidentification with toxic plants like hemlock makes it particularly dangerous during pregnancy. Women who are pregnant, planning pregnancy, or breastfeeding should not use this herb. Evidence level: C (traditional contraindication).

What are the main safety concerns with Anthriscus sylvestris?

The primary safety concerns are photosensitivity from furocoumarins and the critical risk of misidentification. The plant closely resembles poisonous hemlock (Conium maculatum) and other toxic Apiaceae species, making correct identification essential. Furocoumarins can cause skin sensitivity to sunlight, potentially resulting in photodermatitis or skin reactions upon sun exposure. The herb is contraindicated in pregnancy. Only properly trained individuals should harvest this plant. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Anthriscus sylvestris, commonly known as wild chervil or cow parsley, is a perennial herb from the Apiaceae family recognized for its high content of bioactive lignans with potential antitumor and anti-inflammatory properties [PMID:38674496, PMID:34560578].

Contexte

Anthriscus sylvestris is a widespread, wild-growing herbaceous plant found in temperate regions, including Europe, Asia, and New Zealand [PMID:34560578, PMID:29377739]. It is categorized as a biennial or perennial herb and is sometimes regarded as a noxious weed [PMID:38288817, PMID:38674496].

Usages traditionnels

Traditionally used to treat headaches, coughs, gastric disorders, spleen deficiency, limb weakness, and as a tonic, antitussive, antipyretic, analgesic, and diuretic [PMID:38674496, PMID:38288817, PMID:26287153]. It has also been used for dressing wounds [PMID:38674496].

Composés actifs

The plant is rich in lignans, particularly aryltetralins and dibenzylbutyrolactones, with dominant compounds including deoxypodophyllotoxin, nemerosin, yatein, podophyllotoxone, and guaiadequiol [PMID:38674496, PMID:34560578, PMID:36144804]. Other constituents include a neutral heteropolysaccharide (AP) in the roots [PMID:39233161], volatile monoterpenes such as beta-phellandrene [PMID:12214699], and malonyl-caffeoylquinic acids [PMID:41048795].

Mécanisme d'action

Deoxypodophyllotoxin (DPT) inhibits the PI3K/Akt/mTORC1 pathway in breast cancer cells [PMID:23818925] and triggers glioma cell death via parthanatos by activating PARP1 and SIRT1 [PMID:37277492]. DPT also alleviates hepatic fat accumulation by inhibiting liver X receptor alpha-mediated SREBP-1c induction via AMP-activated protein kinase [PMID:30148990]. Root polysaccharides (AP) boost antioxidant enzymes via the Nrf2/HO-1/NQO1 signaling pathway [PMID:39233161]. Root extracts may reduce allergic lung inflammation by regulating interferon regulatory factor 4-mediated Th2 cell activation [PMID:30552991].

Preuves cliniques

Preuve DCancer (various cell lines)

Deoxypodophyllotoxin and other petroleum ether fraction isolates show antitumor and antiproliferative activity against breast cancer (MCF7, MDA-MB-231), hepatocellular carcinoma (HepG2), osteosarcoma (MG-63), melanoma (B16), and cervical carcinoma (HeLa) cells in vitro [PMID:23818925, PMID:24761904, PMID:26287153].

Preuve DAllergic Asthma/Lung Inflammation

Root extracts attenuated mucus secretion, inflammatory cell infiltration, and Th2 cytokine levels in OVA-induced asthma mouse models [PMID:30552991]. A fermented extract mixture containing A. sylvestris decreased coughs in guinea pigs and reduced lung inflammation in mice [PMID:34393544].

Preuve DFatty Liver

Oral administration of deoxypodophyllotoxin (5 and 10 mg/kg) decreased lipid accumulation in the liver of high-fat diet-induced C57BL/6 mice [PMID:30148990].

Preuve DAging

Root polysaccharides (AP) demonstrated in vivo anti-aging activity in D-gal-induced aging mice by boosting antioxidant enzymes and mitigating immune decline [PMID:39233161].

Preuve DInflammation

Aqueous leaf extracts inhibited LPS-induced secretion of nitric oxide and prostaglandin E2 in RAW264.7 cells and attenuated inflammatory mediators (TNF-alpha, IL-1beta, IL-6) [PMID:29377739].

Synthèse des preuves

The current evidence is primarily based on in vitro cell studies and in vivo animal models (Level D). While there is strong phytochemical evidence regarding its lignan content and promising preclinical data for anticancer and anti-inflammatory activities, there are no human clinical trials provided in the source material.

Sources PubMed

1.PMID: 38674496 (2024) — Anthriscus sylvestris-Noxious Weed or Sustainable Source of Bioactive Lignans? · Plants (Basel, Switzerland)
2.PMID: 37948767 (2023) — Anthriscus sylvestris Deoxypodophyllotoxin Synthase Involved in the Podophyllotoxin Biosynthesis. · Plant & cell physiology
3.PMID: 34560578 (2021) — Comprehensive study of Anthriscus sylvestris lignans. · Phytochemistry
4.PMID: 39233161 (2024) — Structural characterization, anti-aging activity and mechanisms investigation in vivo of a polysaccharide from Anthriscus sylvestris. · International journal of biological macromolecules
5.PMID: 36144804 (2022) — Quantitative HPLC-UV Study of Lignans in Anthriscus sylvestris. · Molecules (Basel, Switzerland)

Anthriscus sylvestris

Sources et citations

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