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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Aristolochia indica
Aristolochiacée d'Asie du Sud; utilisée en Ayurveda contre les piqûres de serpent et la fièvre; RISQUE DE NÉPHROTOXICITÉ SÉVÈRE.
Aristolochia indica is a toxic herb from the Aristolochiaceae family, traditionally used in Ayurveda for snakebite and fever, but its primary constituent aristolochic acid is a potent nephrotoxin and carcinogen. Due to severe risks of irreversible kidney failure and urothelial cancer, its internal use is contraindicated. The herb contains aristolochic acid, alkaloids, and flavonoids, but no safe therapeutic application exists.
Aristolochic acid (AA) is metabolically activated to form DNA adducts, primarily at adenine residues, leading to mutations in the TP53 tumor suppressor gene and activation of the RAS pathway, promoting urothelial carcinoma. AA also induces proximal tubular cell apoptosis and interstitial fibrosis via oxidative stress, mitochondrial dysfunction, and activation of TGF-β1 signaling, resulting in progressive nephropathy. The herb's alkaloids may contribute to additional toxicity, but AA is the primary driver of its harmful effects.
Aristolochiacée d'Asie du Sud; utilisée en Ayurveda contre les piqûres de serpent et la fièvre; RISQUE DE NÉPHROTOXICITÉ SÉVÈRE.
Aristolochia indica is a toxic herb from the Aristolochiaceae family, traditionally used in Ayurveda for snakebite and fever, but its primary constituent aristolochic acid is a potent nephrotoxin and carcinogen. Due to severe risks of irreversible kidney failure and urothelial cancer, its internal use is contraindicated. The herb contains aristolochic acid, alkaloids, and flavonoids, but no safe therapeutic application exists.
Aristolochic acid (AA) is metabolically activated to form DNA adducts, primarily at adenine residues, leading to mutations in the TP53 tumor suppressor gene and activation of the RAS pathway, promoting urothelial carcinoma. AA also induces proximal tubular cell apoptosis and interstitial fibrosis via oxidative stress, mitochondrial dysfunction, and activation of TGF-β1 signaling, resulting in progressive nephropathy. The herb's alkaloids may contribute to additional toxicity, but AA is the primary driver of its harmful effects.