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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Artemisia argyi, also known as Chinese mugwort or wormwood, is a traditional medicinal herb used in East Asia for its antibacterial, anti-inflammatory, and antioxidant properties [PMID:34242729, PMID:38296909].
Contexte
Artemisia argyi is a perennial herbaceous plant of the Asteraceae family [PMID:39222778, PMID:39701793]. It is widely distributed in Asia, particularly China, and its leaves are primarily used for medicinal purposes [PMID:35795352, PMID:37044183].
Usages traditionnels
Historically, it has been used for hundreds of years to treat eczema, respiratory diseases, gynecological diseases [PMID:34242729], abdominal pain, gastric ulcers, diarrhea, and gastritis [PMID:40816579]. It is also used as an insect repellent during the Dragon Boat Festival in China [PMID:39485326] and in moxibustion therapy to treat 'deficiency-cold syndromes' [PMID:40426190].
Composés actifs
Main components include flavonoids [PMID:34242729], polysaccharides [PMID:39222778], alkaloids, and volatile oils containing terpenes, aldehydes, ketones, alcohols, and esters [PMID:39222778, PMID:41573729]. Specific identified compounds include eriodictyol, umbelliferone [PMID:37381062], (+)-intermedeol [PMID:39485326], and various sesquiterpenoids [PMID:37918620, PMID:34847785].
Mécanisme d'action
Mechanisms include the activation of TRPML1 to promote autophagy/mitophagy clearance [PMID:35752074], inhibition of the PI3K-AKT pathway to combat Influenza A virus [PMID:41317814], and ROS scavenging via stabilization of HSPA5 to prevent GPX4 degradation [PMID:41559762]. Its essential oil inhibits the NLRP3 inflammasome and phosphorylation of NF-κB p65 to reduce pro-inflammatory metabolites like IL-1β, IL-6, and TNF-α [PMID:41573729].
Preuves cliniques
Preuve BFunctional Dyspepsia
An ethanol extract (RW0117) significantly alleviated symptoms on the gastrointestinal symptom-rating scale (GSRS) [PMID:40816579]
Preuve BIrritable Bowel Syndrome with Diarrhea (IBS-D)
Mild moxibustion was evaluated for efficacy compared to placebo [PMID:35114338]
Sécurité et effets indésirables
A randomized clinical trial on an ethanol extract (RW0117) for functional dyspepsia evaluated adverse events as part of its safety profile [PMID:40816579]. Artificial aging of leaves is noted to reduce irritation during treatment [PMID:38643715].
Synthèse des preuves
Evidence consists primarily of in vitro and in vivo animal models (D) and a limited number of randomized controlled trials (B) focusing on gastrointestinal health and moxibustion.
Sources PubMed
1.PMID: 34242729 (2021) — Antioxidant capacity of flavonoids from Folium Artemisiae Argyi and the molecular mechanism in Caenorhabditis elegans. · Journal of ethnopharmacology
2.PMID: 35752074 (2022) — Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease. · Phytomedicine : international journal of phytotherapy and phytopharmacology
3.PMID: 35114338 (2022) — Mild moxibustion for Irritable Bowel Syndrome with Diarrhea (IBS-D): A randomized controlled trial. · Journal of ethnopharmacology
4.PMID: 38296909 (2024) — Natural herb wormwood-based microneedle array for wound healing. · Drug delivery and translational research
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— Gene-Directed In Vitro Mining Uncovers the Insect-Repellent Constituent from Mugwort (Artemisia argyi).
· Journal of the American Chemical Society
6.PMID: 42285686 (2026) — Anti-pathogenic effects of Artemisia argyi and its applications: the past, present, and future. · Chinese journal of natural medicines
7.PMID: 41559762 (2026) — Artemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment. · Journal of nanobiotechnology
8.PMID: 41573729 (2025) — Pharmacological and bioactive properties of Artemisia argyi H. Lév. & Vaniot essential oil: a review. · Frontiers in pharmacology
9.PMID: 40426190 (2025) — Grain-sized moxibustion activates dendritic cells to enhance the antitumor immunity of cancer vaccines. · Chinese medicine
10.PMID: 37638613 (2023) — Review of the Chemical Composition and Biological Activities of Essential Oils from Artemisia Argyi, Artemisia Princeps, and Artemisia Montana. · Current topics in medicinal chemistry
11.PMID: 37381062 (2023) — Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2. · Cell & bioscience
13.PMID: 41390517 (2025) — The Artemisia argyi oil reduces high-fat diet-induced obesity by enhancing thermogenesis in brown adipose tissue. · NPJ science of food
14.PMID: 42319360 (2026) — Standardized Artemisia argyi Extract Alleviates Scopolamine-Induced Memory Impairment in Mice. · Journal of medicinal food
15.PMID: 37918620 (2024) — Sesquiterpenoids from aged Artemisia argyi and their 3D-QSAR for anti-HBV activity. · Phytochemistry
16.PMID: 41240544 (2025) — Artemisia argyi ethyl acetate fraction suppresses ovarian cancer progression via JUN/MAPK10 signaling: An integrated multi-omics investigation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
17.PMID: 38643715 (2024) — Artificial aging conditions for Artemisia argyi leaves based on quality-inflammation-quality marker transformation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
18.PMID: 36579954 (2023) — Quantitative fingerprint and antioxidative properties of Artemisia argyi leaves combined with chemometrics. · Journal of separation science
19.PMID: 34847785 (2023) — Chemical constituents and biological activities of Artemisia argyi H.Lév. & vaniot. · Natural product research
20.PMID: 39222778 (2024) — Recent advances in Artemisia argyi Levl. et Vant. polysaccharides: Extractions, purifications, structural characteristics, pharmacological activities, and existing and potential applications. · International journal of biological macromolecules
21.PMID: 41172921 (2025) — Metabolomics and network pharmacology revealing the transdermal moxibustion compounds and their therapeutic mechanisms for rheumatoid arthritis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
22.PMID: 40520866 (2025) — Kang Ru enhances paclitaxel's efficacy against breast cancer progression. · American journal of cancer research
23.PMID: 39671784 (2025) — Sesquiterpene lactone from Artemisia argyi inhibited cancer proliferation by inducing apoptosis and ferroptosis via key cell metabolism enzyme NDUFA4. · Phytomedicine : international journal of phytotherapy and phytopharmacology
24.PMID: 39701793 (2024) — [Development of DUS testing guidelines of Artemisia argyi]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
25.PMID: 40816579 (2025) — Safety and efficacy of Artemisia argyi extract RW0117 for functional dyspepsia: A randomized, double-blind, placebo-controlled clinical study. · Journal of ethnopharmacology
26.PMID: 41586916 (2026) — Discovery and characterization of a novel marafivirus from Artemisia argyi plants. · Archives of virology
27.PMID: 35795352 (2022) — Sequence Characteristics and Phylogenetic Analysis of the Artemisia argyi Chloroplast Genome. · Frontiers in plant science
28.PMID: 37044183 (2023) — Mitochondrial genome of Artemisia argyi L. suggested conserved mitochondrial protein-coding genes among genera Artemisia, Tanacetum and Chrysanthemum. · Gene
29.PMID: 41317814 (2026) — Methanol extract of Artemisia argyi against influenza a virus via inhibition of PI3K-AKT pathway activation. · Journal of ethnopharmacology