Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Artemisia judaica work to lower blood sugar and fight infections?
Artemisia judaica exerts its medicinal effects through active compounds like artabsin, flavonoids, and davanone. These constituents demonstrate hypoglycemic properties by modulating glucose metabolism and enhancing insulin sensitivity, which supports its traditional use for diabetes. Additionally, the plant contains thujone and sesquiterpene lactones, which provide antimicrobial and antiparasitic activity against various pathogens. Evidence Level C suggests these mechanisms are supported by in vitro and animal studies rather than extensive human clinical trials.
Can I take Artemisia judaica if I am on diabetes medication?
Caution is advised when taking Artemisia judaica alongside diabetes medications. Because the herb has demonstrated hypoglycemic effects, combining it with insulin or oral hypoglycemic drugs may cause blood sugar levels to drop too low (hypoglycemia). Patients managing diabetes should monitor their glucose levels closely and consult a healthcare provider before use. There is also a potential for liver interactions due to thujone metabolism, which may affect drug clearance (Evidence Level C).
What is the recommended daily dosage for Artemisia judaica?
The standard adult dosage for Artemisia judaica is 2 to 4 grams of dried herb daily or 1 to 2 milliliters of tincture. This amount is based on traditional use and pharmacological guidelines (Evidence Level C). Due to the presence of thujone, a neurotoxic compound, users should strictly adhere to these limits and avoid long-term use without professional supervision. It is typically prepared as an infusion or taken as an extract.
Is Artemisia judaica safe to use during pregnancy?
No, Artemisia judaica is unsafe during pregnancy and breastfeeding. The herb contains thujone, which acts as an emmenagogue (stimulates uterine blood flow) and can trigger uterine contractions, potentially leading to miscarriage. Historically, this plant was used to induce menstruation, further indicating its risk to fetal development. Women who are pregnant, nursing, or planning to conceive should strictly avoid this herb to prevent serious complications (Evidence Level C/Traditional).
What are the side effects and contraindications of Artemisia judaica?
Common side effects include gastrointestinal upset, such as nausea or stomach cramps. More serious risks are associated with its thujone content, which can cause neurological effects like dizziness, seizures, and tremors at high doses. Consequently, individuals with epilepsy, liver disease, or kidney disorders should avoid this herb entirely. Long-term or excessive consumption increases the risk of thujone accumulation and neurotoxicity (Evidence Level C).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Artemisia judaica is an aromatic medicinal plant native to regions including Egypt, Jordan, and Saudi Arabia, recognized for its diverse pharmacological properties [PMID:33412247, PMID:27318275, PMID:38930948].
Contexte
Artemisia judaica L. is a Mediterranean aromatic plant that grows widely in areas such as Saint Katherine in Sinai, Egypt, and the southern desert of Jordan [PMID:33412247, PMID:27318275].
Usages traditionnels
It is used in traditional and folk medicine for the treatment of antibacterial, anthelmintic, antidiabetic, analgesic, and anti-inflammatory activities [PMID:33412247]. Other reported traditional uses include the treatment of fungal infections, atherosclerosis, cancer, diabetes, arthritis, inflammatory-related diseases, stomach ache, heart diseases, sexual weakness, gastro-intestinal disorders, and external wounding [PMID:33412247, PMID:27318275, PMID:35204215]. In Jordan, it is recommended by aboriginal Bedouins as a calmative [PMID:27318275].
Composés actifs
The essential oil contains monoterpenes (38.6%), sesquiterpenes (14.1%), ethyl esters, and cyclic ketones, with primary components being piperitone (16.5%), ethyl cinnamate (12.9%), and camphor (9.7%) [PMID:38930948]. Other identified compounds include the flavonoid cirsimaritin [PMID:36139916], the sesquiterpene lactone vulgarin [PMID:37175138, PMID:36555498], and arteperoxides A-C (tris-normonoterpene-sesquiterpene conjugates with peroxide bridges) [PMID:36481317].
Mécanisme d'action
A. judaica extract may diminish diabetes-induced reproductive dysfunction via activation of Nrf2/HO-1-mediated antioxidant responses [PMID:33732055]. The compound vulgarin modulates PEPCK and G6Pase genes expression to improve antidiabetic effectiveness [PMID:36555498] and exhibits preferential inhibitory activity towards COX-2 [PMID:37175138].
Preuves cliniques
Preuve DPneumonia (K. pneumoniae)
Extract was effective against K. pneumoniae-induced pneumonia in male albino rats [PMID:40265251]
Preuve DDiabetes-related complications
Extract showed protective effects against hepatorenal injury [PMID:32666453], neuroprotective effects against neuronal deficits [PMID:32588466], and protective effects against diabetes-induced testicular disorders in rats [PMID:33732055]
Preuve DDiabetes (Glycemic control)
Vulgarin improved fasting blood glucose, insulin, and glycated hemoglobin when combined with glibenclamide in diabetic rats [PMID:36555498]
Preuve DWound Healing
Essential oil demonstrated wound healing activity in a second-degree skin burn rat model [PMID:35204215]
Preuve DParasitic Infections
Ethanolic extracts showed antiparasitic efficacy against Ascaridia galli in poultry [PMID:41679004] and significant growth inhibition of Blastocystis (99.3%) in vitro [PMID:31058875]
Preuve D
Sécurité et effets indésirables
Analysis of medicinal plants from Madina, Saudi Arabia, including 'sheeh' (Artemisia), identified the presence of toxic elements such as Al, Pb, As, and Cd, though washing processes were found to lower these elements [PMID:29019913].
Synthèse des preuves
The current evidence consists primarily of in vitro studies and animal models (rats, poultry, mice), indicating strong pharmacological potential but lacking human clinical trials.
Sources PubMed
1.PMID: 38930948 (2024) — Chemical Composition and Cytotoxicity Evaluation of Artemisia judaica L. Essential Oil from Saudi Arabia. · Molecules (Basel, Switzerland)
2.PMID: 41679004 (2026) — Anthelmintic effects of Artemisia herba-alba and Artemisia judaica extracts on Ascaridia galli in poultry. · Poultry science
3.PMID: 36139916 (2022) — The Current State of Knowledge in Biological Properties of Cirsimaritin. · Antioxidants (Basel, Switzerland)
4.PMID: 33412247 (2021) — Pharmacological activity and flavonoids constituents of Artemisia judaica L aerial parts. · Journal of ethnopharmacology
5.PMID: 40265251 (2025) — Artemisia judaica extract is effective against Klebsiella pneumoniae-induced pneumonia in male albino rats. · Biotechnic & histochemistry : official publication of the Biological Stain Commission
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Extract showed weak-to-moderate activity against P. falciparum erythrocytic blood stages in vitro [PMID:35550108]
6.PMID: 38931335 (2024) — Exploring the Antibacterial Potential of Artemisia judaica Compounds Targeting the Hydrolase/Antibiotic Protein in Klebsiella pneumoniae: In Vitro and In Silico Investigations. · Pharmaceuticals (Basel, Switzerland)
7.PMID: 37476671 (2023) — Anti-Cryptosporidium parvum activity of Artemisia judaica L. and its fractions: in vitro and in vivo assays. · Frontiers in microbiology
8.PMID: 33732055 (2021) — Artemisia judaica L. diminishes diabetes-induced reproductive dysfunction in male rats via activation of Nrf2/HO-1-mediated antioxidant responses. · Saudi journal of biological sciences
9.PMID: 34063007 (2021) — Plant Preparations and Compounds with Activities against Biofilms Formed by Candida spp. · Journal of fungi (Basel, Switzerland)
10.PMID: 29019913 (2017) — Toxic Elements in Different Medicinal Plants and the Impact on Human Health. · International journal of environmental research and public health
11.PMID: 36481317 (2023) — Arteperoxides A-C, tris-normonoterpene-sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity. · Phytochemistry
12.PMID: 27318275 (2016) — Chemical composition and biological activities of Artemisia judaica essential oil from southern desert of Jordan. · Journal of ethnopharmacology
13.PMID: 32666453 (2020) — Protective effects of Artemisia judaica extract compared to metformin against hepatorenal injury in high-fat diet/streptozotocine-induced diabetic rats. · Environmental science and pollution research international
14.PMID: 31058875 (2019) — Anti-Blastocystis Activity In Vitro of Egyptian Herbal Extracts (Family: Asteraceae) with Emphasis on Artemisia judaica. · International journal of environmental research and public health
15.PMID: 38958755 (2024) — Endophytic Aspergillus fumigatiaffinis: Novel paclitaxel production and optimization insights. · Applied microbiology and biotechnology
16.PMID: 15099906 (2004) — Artemisia judaica L.: micropropagation and antioxidant activity. · Journal of biotechnology
17.PMID: 35550108 (2022) — Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities. · BMC complementary medicine and therapies
18.PMID: 35204215 (2022) — Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant's Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory, and Antibiofilm Properties of the Plant's Essential Oils. · Antioxidants (Basel, Switzerland)
19.PMID: 32588466 (2020) — Evaluation of the neuro-protective effect of Artemisia judaica extract in a murine diabetic model. · Journal of food biochemistry
21.PMID: 24339945 (2013) — Physiological conjunction of allelochemicals and desert plants. · PloS one
22.PMID: 39037974 (2024) — Acaricidal activity of Egyptian crude plant extracts against Haemaphysalis longicornis ticks. · PloS one
23.PMID: 37175138 (2023) — Microbial Transformation of the Sesquiterpene Lactone, Vulgarin, by Aspergillus niger. · Molecules (Basel, Switzerland)
24.PMID: 36555498 (2022) — Vulgarin, a Sesquiterpene Lactone from Artemisia judaica, Improves the Antidiabetic Effectiveness of Glibenclamide in Streptozotocin-Induced Diabetic Rats via Modulation of PEPCK and G6Pase Genes Expression. · International journal of molecular sciences
25.PMID: 36984883 (2023) — Phytochemicals Identification and Bioactive Compounds Estimation of Artemisia Species Grown in Saudia Arabia. · Metabolites