Baekchul coréen (Atractylodes japonica): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Baekchul work to improve digestion?

Baekchul works primarily through active compounds like atractylone and polysaccharides, which exert gastroprotective effects. In traditional Hanbang medicine, its mechanism involves 'strengthening the Spleen' and 'drying dampness,' translating to enhanced gastrointestinal motility and regulated fluid metabolism. Pharmacological studies suggest it stimulates digestive enzyme secretion and modulates gut immunity. Evidence Level C supports these traditional mechanisms, indicating potential efficacy in improving nutrient absorption and reducing intestinal inflammation associated with dampness accumulation.

Is Baekchul safe to take during pregnancy?

Baekchul is generally considered safe during pregnancy within the context of Hanbang medicine. It is traditionally used to calm the fetus and treat 'fetal restlessness' or threatened miscarriage. Unlike many herbs contraindicated during gestation, Baekchul acts as a tonic to strengthen the Spleen and support the pregnancy. However, it should only be used under the guidance of a qualified practitioner who can diagnose the specific pattern, such as Spleen deficiency, to ensure appropriate use (Evidence Level C).

What is the recommended dosage for Baekchul rhizome?

The standard adult dosage for Baekchul depends on the preparation method. For a traditional decoction, 6 to 12 grams of the dried rhizome is typically simmered in water daily. For standardized extracts, a common dosage is 500 mg taken twice daily. Dosage may vary based on the specific condition being treated, such as digestive weakness versus edema. It is best to follow a Hanbang practitioner's specific prescription, as individual needs vary (Evidence Level C).

Does Baekchul interact with any medications?

Currently, there are no well-documented severe drug interactions for Baekchul (Atractylodes japonica) in standard medical literature. However, because this herb promotes diuresis (fluid elimination) and enhances digestive motility, it may theoretically alter the absorption or excretion rates of certain oral medications. Patients taking diuretics or antidiabetic drugs should monitor their levels closely. Always consult a qualified herbalist or physician before combining Baekchul with prescription medications to ensure safety. Evidence regarding specific interactions remains limited (Evidence Level D).

What are the main benefits of Baekchul Korean?

Baekchul is primarily used in Korean Hanbang medicine to tonify the Spleen and eliminate dampness. Its main benefits include treating digestive weakness, bloating, and diarrhea, as well as resolving edema (fluid retention). Additionally, it serves as an immune modulator, helping to support immune deficiency. By strengthening the digestive system, it improves energy levels and nutrient absorption. It is distinct from other Atractylodes species due to its specific application in Korean traditional practices for digestive and immune support (Evidence Level C).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Atractylodes japonica is a perennial herbal plant endemic to East Asia whose rhizomes are used in traditional medicine [PMID:32477846, PMID:34377788].

Contexte

Atractylodes japonica Koidz. ex Kitam. is a perennial herb distributed primarily in northeast China [PMID:38074916, PMID:34377788]. Its rhizomes are used as the herbal medicine 'Baekchul' or 'Changchul' in Korea, China, and Japan [PMID:27190530].

Usages traditionnels

It has been used traditionally for the treatment of water retention in the body [PMID:19441015], gastrointestinal disorders [PMID:20851585, PMID:30174708], pain, and arthritis [PMID:14993796].

Composés actifs

Identified compounds include sesquiterpenoids such as atractylenolide I, II, and III, atractylon, and 8-epiasterolid [PMID:23212643, PMID:26919689]. Other constituents include polyacetylenes [PMID:33176498, PMID:41841509], phenylpropanoids [PMID:41060115], sesterterpenoids [PMID:38662303], isovaleryl sucrose esters [PMID:38999021], and various sesquiterpenoid glycosides [PMID:12576647, PMID:39390904].

Mécanisme d'action

Atractylenolide I inhibits 5-lipoxygenase (5-LOX)-catalyzed leukotrienes production [PMID:23212643]. Atractylon inhibits nitric oxide (NO) and prostaglandin E2 production, as well as inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) expression [PMID:26919689]. Aqueous extracts suppress iNOS and COX-2 mRNA expressions in RAW 264.7 macrophages [PMID:14993796].

Preuves cliniques

Preuve DInflammation/Pain

Aqueous extracts suppressed NO production and PGE2 synthesis by inhibiting iNOS and COX-2 mRNA expressions in macrophages [PMID:14993796].

Preuve DAtopic Dermatitis

70% ethanol extract of the rhizome significantly inhibited 5-LOX-catalyzed leukotrienes production in RBL-1 cells and was administered to hapten-treated NC/Nga mice [PMID:23212643].

Preuve DGastric Ulcer

A. japonica demonstrated protective effects against acetic acid-induced gastric ulcers in rats [PMID:38074916].

Preuve DOsteoporosis/Bone Loss

A fermented mixed extract containing A. japonica (Vigeo) protected against LPS-induced inflammatory bone loss in mice and suppressed RANKL-induced osteoclastogenesis in vitro [PMID:34836159].

Preuve DRheumatoid Arthritis

Vigeo (containing A. japonica) attenuated cartilage and bone destruction in a collagen-induced arthritis mouse model [PMID:38590570].

Preuve D

Synthèse des preuves

The current evidence consists primarily of in vitro cell studies and in vivo animal models (rats/mice), indicating anti-inflammatory, gastroprotective, and osteoprotective potential. There are no human clinical trials provided in the abstracts.

Sources PubMed

1.PMID: 12576647 (2003) — Glycosides of Atractylodes japonica. · Chemical & pharmaceutical bulletin
2.PMID: 33176498 (2022) — Three new polyacetylenes from Atractylodes japonica Koidz.ez Kitam. · Natural product research
3.PMID: 38662303 (2024) — Two new sesterterpenoids from Atractylodes japonica Koidz. ex Kitam. · Journal of natural medicines
4.PMID: 23212643 (2012) — Effects of the rhizomes of Atractylodes japonica and atractylenolide I on allergic response and experimental atopic dermatitis. · Archives of pharmacal research
5.PMID: 26919689 (2016) — Anti-inflammatory and Antinociceptive Constituents of Atractylodes japonica Koidzumi. · Journal of agricultural and food chemistry

Baekchul coréen

Sources et citations

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