Bauhinia purpurea (Bauhinia purpurea): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Bauhinia purpurea work for thyroid conditions?

Bauhinia purpurea contains flavonoids, quercetin, and bauhinin which are believed to modulate thyroid function through antioxidant activity. The plant's active compounds may influence thyroid hormone metabolism, though the exact mechanism remains poorly understood. Research is limited to preliminary animal and in vitro studies (Evidence Level C). Traditional use suggests thyroid-modulating effects, but human clinical trials are lacking. More research is needed to fully understand how this herb affects thyroid physiology.

Does Bauhinia purpurea interact with thyroid medications?

Bauhinia purpurea may interact with thyroid medications such as levothyroxine and other hormone replacements. Because this herb appears to modulate thyroid function, concurrent use could potentially alter medication effectiveness or thyroid hormone levels. Patients taking thyroid medications should avoid this herb or use it only under medical supervision. No formal drug interaction studies exist (Evidence Level C), so caution is advised. Always consult a healthcare provider before combining herbal remedies with prescription medications.

What is the recommended dosage for Bauhinia purpurea bark?

The traditional adult dosage for Bauhinia purpurea bark is 5-10 grams prepared as a decoction, taken twice daily. This preparation involves boiling the bark in water and straining before consumption. Standardized extracts may have different dosing requirements. Due to limited clinical research (Evidence Level C), there are no established pharmaceutical grade dosing guidelines. Users should follow traditional preparation methods or consult a qualified herbalist for personalized dosing recommendations.

Is Bauhinia purpurea safe during pregnancy?

Bauhinia purpurea is considered unsafe during pregnancy and should be avoided. The herb contains compounds that may affect hormonal balance and thyroid function, which could potentially harm fetal development. Traditional contraindications explicitly list pregnancy as a reason to avoid use. Women who are pregnant, nursing, or attempting to conceive should not use this herb. There is insufficient safety data to support use during pregnancy, and the potential risks outweigh any theoretical benefits.

What are the traditional uses of Bauhinia purpurea?

Bauhinia purpurea has been traditionally used in South and Southeast Asian medicine for thyroid conditions, skin diseases, digestive complaints, and diabetes. The leaves and bark are the primary parts used medicinally. The herb contains flavonoids, tannins, bauhinin, quercetin, and alkaloids which contribute to its therapeutic properties. Evidence supporting these uses is limited to traditional knowledge and preliminary research (Evidence Level C). Human clinical trials are needed to validate these traditional applications.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Bauhinia purpurea is a medium-sized tree from the Fabaceae family used traditionally in medicine by tribes in Sikkim [PMID:38694794]. It has demonstrated various pharmacological activities in animal models, including anti-inflammatory, wound healing, and organ-protective effects [PMID:20336222, PMID:20582204, PMID:20502576].

Contexte

Bauhinia purpurea is a plant of the legume family (Leguminosae/Fabaceae) widely distributed in South China and used globally as both an ornamental and medicinal plant [PMID:39828674, PMID:39796252].

Usages traditionnels

The plant is traditionally used as medicine by different tribes in Sikkim [PMID:38694794] and has been used since ancient times for treating various inflammatory conditions, including arthritis [PMID:31031464].

Composés actifs

The bark contains a new phenylpropanoid glucoside called purpuroside and eight other known compounds [PMID:30580598]. The seeds contain Bauhinia purpurea agglutinin (BPA), a Galbeta1-3GalNAc (T) specific leguminous lectin [PMID:14741734, PMID:1657898]. General phytochemicals reported in hepatoprotective plants including B. purpurea include alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones [PMID:35268634].

Mécanisme d'action

The bark extracts exhibit NO inhibitory activity in mouse peritoneal macrophages [PMID:30580598]. In a polyherbal formulation, it contributed to the attenuation of inflammation and oxidative stress via upregulation of Nrf-2, HO-1, superoxide dismutase, and catalase, and downregulation of TNF-alpha and NF-kappaB [PMID:34740211]. The lectin (BPA) binds to specific carbohydrate structural units, including Galbeta1-3GalNAc [PMID:14741734].

Preuves cliniques

Preuve DMultidrug-resistant Staphylococcus aureus

Methanol extract of the bark exhibited an antibiotic potentiating effect, reducing the MIC of clindamycin by 16-fold and showing synergistic activity with penicillin [PMID:38694794]

Preuve DWound Healing (Rats)

Methanol and chloroform extracts significantly reduced the time for epithelization and wound contraction in excision and burn models, and increased breaking strength in incision and dead space models [PMID:20582204]

Preuve DArthritis (Rats)

Hydroalcoholic extract from the stem bark demonstrated significant anti-arthritic and anti-inflammatory activity [PMID:31031464]

Preuve DNephrotoxicity (Rats)

Ethanol extracts of leaves and unripe pods significantly protected rat kidneys from gentamicin-induced histopathological changes [PMID:20502576]

Preuve DHepatocarcinogenesis (Rats)

Oral pretreatment significantly decreased serum toxicity markers, elevated antioxidant enzyme activities, and reduced tumor incidences [PMID:24082504]

Preuve D

Sécurité et effets indésirables

In rats, the bark extract showed no toxicological effect in an oral subacute toxicity study (28 days) and a LD50 value of >2 g/kg in an acute toxicity study (5 days) [PMID:31031464].

Interactions médicamenteuses

The methanol extract of the bark exhibits synergistic activity with antibiotics such as penicillin, clindamycin, and gentamicin [PMID:38694794].

Synthèse des preuves

The evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential antibacterial, anti-inflammatory, and organ-protective properties. No human clinical trials were provided.

Sources PubMed

1.PMID: 38694794 (2024) — Antibiotic potentiating effect of Bauhinia purpurea L. against multidrug resistant Staphylococcus aureus. · Frontiers in microbiology
2.PMID: 34167392 (2022) — Study of cardioprotective activity of the methanolic extract of the aerial parts of Bauhinia madagascariensis compared to Bauhinia purpurea against adrenaline-induced myocardial toxicity in rats. · Drug and chemical toxicology
3.PMID: 3051929 (1988) — The separation of immunocyte subpopulations by use of various lectins. · Advances in experimental medicine and biology
4.PMID: 35268634 (2022) — Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms. · Molecules (Basel, Switzerland)
5.PMID: 9343930 (1997) — Differential binding properties of Gal/GalNAc specific lectins available for characterization of glycoreceptors.

Bauhinia purpurea

Sources et citations

Calculer une dose sûre de Bauhinia purpurea