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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Bauhinia purpurea is a medium-sized tree from the Fabaceae family used traditionally in medicine by tribes in Sikkim [PMID:38694794]. It has demonstrated various pharmacological activities in animal models, including anti-inflammatory, wound healing, and organ-protective effects [PMID:20336222, PMID:20582204, PMID:20502576].
Contexte
Bauhinia purpurea is a plant of the legume family (Leguminosae/Fabaceae) widely distributed in South China and used globally as both an ornamental and medicinal plant [PMID:39828674, PMID:39796252].
Usages traditionnels
The plant is traditionally used as medicine by different tribes in Sikkim [PMID:38694794] and has been used since ancient times for treating various inflammatory conditions, including arthritis [PMID:31031464].
Composés actifs
The bark contains a new phenylpropanoid glucoside called purpuroside and eight other known compounds [PMID:30580598]. The seeds contain Bauhinia purpurea agglutinin (BPA), a Galbeta1-3GalNAc (T) specific leguminous lectin [PMID:14741734, PMID:1657898]. General phytochemicals reported in hepatoprotective plants including B. purpurea include alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones [PMID:35268634].
Mécanisme d'action
The bark extracts exhibit NO inhibitory activity in mouse peritoneal macrophages [PMID:30580598]. In a polyherbal formulation, it contributed to the attenuation of inflammation and oxidative stress via upregulation of Nrf-2, HO-1, superoxide dismutase, and catalase, and downregulation of TNF-alpha and NF-kappaB [PMID:34740211]. The lectin (BPA) binds to specific carbohydrate structural units, including Galbeta1-3GalNAc [PMID:14741734].
Preuves cliniques
Preuve DMultidrug-resistant Staphylococcus aureus
Methanol extract of the bark exhibited an antibiotic potentiating effect, reducing the MIC of clindamycin by 16-fold and showing synergistic activity with penicillin [PMID:38694794]
Preuve DWound Healing (Rats)
Methanol and chloroform extracts significantly reduced the time for epithelization and wound contraction in excision and burn models, and increased breaking strength in incision and dead space models [PMID:20582204]
Preuve DArthritis (Rats)
Hydroalcoholic extract from the stem bark demonstrated significant anti-arthritic and anti-inflammatory activity [PMID:31031464]
Preuve DNephrotoxicity (Rats)
Ethanol extracts of leaves and unripe pods significantly protected rat kidneys from gentamicin-induced histopathological changes [PMID:20502576]
In rats, the bark extract showed no toxicological effect in an oral subacute toxicity study (28 days) and a LD50 value of >2 g/kg in an acute toxicity study (5 days) [PMID:31031464].
Interactions médicamenteuses
The methanol extract of the bark exhibits synergistic activity with antibiotics such as penicillin, clindamycin, and gentamicin [PMID:38694794].
Synthèse des preuves
The evidence is primarily based on in vitro studies and animal models (Level D), demonstrating potential antibacterial, anti-inflammatory, and organ-protective properties. No human clinical trials were provided.
Sources PubMed
1.PMID: 38694794 (2024) — Antibiotic potentiating effect of Bauhinia purpurea L. against multidrug resistant Staphylococcus aureus. · Frontiers in microbiology
2.PMID: 34167392 (2022) — Study of cardioprotective activity of the methanolic extract of the aerial parts of Bauhinia madagascariensis compared to Bauhinia purpurea against adrenaline-induced myocardial toxicity in rats. · Drug and chemical toxicology
3.PMID: 3051929 (1988) — The separation of immunocyte subpopulations by use of various lectins. · Advances in experimental medicine and biology
4.PMID: 35268634 (2022) — Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms. · Molecules (Basel, Switzerland)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Ethanol extract of the stem showed significant analgesic and anti-inflammatory activities (46.4% to 77% edema inhibition) [PMID:20336222]
Preuve DDiabetic Cardiomyopathy (Rats)
As part of a polyherbal formulation, it attenuated cardiac inflammation and oxidative stress [PMID:34740211]
(1997)
— Differential binding properties of Gal/GalNAc specific lectins available for characterization of glycoreceptors.
· Indian journal of biochemistry & biophysics
6.PMID: 36712959 (2023) — Spatiotemporal changes of tissue glycans depending on localization in cardiac aging. · Regenerative therapy
7.PMID: 20502576 (2009) — Protective Effect of Bauhinia purpurea on Gentamicin-induced Nephrotoxicity in Rats. · Indian journal of pharmaceutical sciences
8.PMID: 3658105 (1987) — Lectin binding in meningiomas. · Neuropathology and applied neurobiology
9.PMID: 2262570 (1990) — Lectin typing of Campylobacter isolates. · Journal of clinical pathology
10.PMID: 14741734 (2004) — Recognition profile of Bauhinia purpurea agglutinin (BPA). · Life sciences
11.PMID: 39828674 (2025) — Assembly and characterization of the complete mitogenome of Bauhinia purpurea (Leguminosae). · BMC genomic data
12.PMID: 39796252 (2025) — Comparative Analysis of Complete Chloroplast Genomes and Phylogenetic Relationships in Medicinally Important Pantropical Genus Bauhinia s.s. (Leguminosae) from Southern Africa and Eastern Asia. · International journal of molecular sciences
13.PMID: 7542024 (1995) — Lectin and immunohistochemical comparison of glycoconjugates in the conjunctiva of patients with and without exfoliation syndrome. · The British journal of ophthalmology
14.PMID: 10082 (1976) — The isolation of lectins on acid-treated agarose. · Carbohydrate research
15.PMID: 20582204 (2010) — Evaluation of Wound Healing Potential of Bauhinia purpurea Leaf Extracts in Rats. · Indian journal of pharmaceutical sciences
16.PMID: 20336222 (2009) — Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities. · Indian journal of pharmacology
17.PMID: 36668735 (2022) — Evaluation of the Toxic Effect of Bauhinia purpurea Mediated Synthesized Silver Nanoparticles against In-vitro and In-vivo Models. · Toxics
18.PMID: 1657898 (1991) — cDNA cloning and expression of Bauhinia purpurea lectin. · Journal of biochemistry
19.PMID: 30580598 (2020) — Chemical constituents from the bark of bauhinia purpurea and their NO inhibitory activities. · Natural product research
20.PMID: 10518527 (1999) — Nonstatistical binding of a protein to clustered carbohydrates. · Proceedings of the National Academy of Sciences of the United States of America
21.PMID: 31031464 (2019) — In vivo anti-arthritic activity of Bauhinia purpurea Linn. Bark Extract. · Indian journal of pharmacology
22.PMID: 34740211 (2022) — Polyherbal Formulation Ameliorates Diabetic Cardiomyopathy Through Attenuation of Cardiac Inflammation and Oxidative Stress Via NF-κB/Nrf-2/HO-1 Pathway in Diabetic Rats. · Journal of cardiovascular pharmacology
23.PMID: 24082504 (2013) — Chemopreventive Effect of Bauhinia Purpurea Against Chemically Induced Hepatocarcinogenesis via Amelioration of Oxidative Damage, Cell Proliferation and Induction of Apoptosis in Wistar Rats. · Toxicology international
24.PMID: 27676385 (2016) — Biofabrication of broad range antibacterial and antibiofilm silver nanoparticles. · IET nanobiotechnology
25.PMID: 2891180 (1987) — Molecular basis of bacterial adhesion in the oral cavity. · Reviews of infectious diseases