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PubMed · A review of <i>Phyllanthus urinaria</i> L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma. (2024)
PubMed · A Review: Mechanism of <i>Phyllanthus urinaria</i> in Cancers-NF-<i>κ</i>B, P13K/AKT, and MAPKs Signaling Activation. (2021)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Phyllanthus urinaria is a medicinal herb with reported antiviral, antibacterial, anti-inflammatory, and anticancer properties [PMID:34484390, PMID:30327602].
Contexte
Phyllanthus urinaria (L.) is an annual perennial herbal species found in tropical Asia, America, China, and the Indian Ocean islands [PMID:30327602]. It is extensively used as ethnopharmacological material in China [PMID:36684764] and in West Africa [PMID:37716546].
Usages traditionnels
In folk medicine, it is used to treat jaundice, diabetes, malaria, and liver diseases [PMID:30327602]. In West Africa, the aerial parts are used against helminthiasis [PMID:37459860].
Composés actifs
The plant contains flavonoids, lignans (such as 5-demethoxyniranthin, urinatetralin, dextrobursehernin, and urinaligran), tannins (including corilagin), phenolics, and terpenoids [PMID:12877924, PMID:39185304, PMID:36635908, PMID:30327602]. Specific identified compounds include gallic acid, brevifolin carboxylic acid, phyllanthusiin C, ellagic acid, and stigmasterol glucoside [PMID:19295228, PMID:30068884].
Mécanisme d'action
Anticancer mechanisms involve the modulation of NF-κB, P13K/AKT, and ERK/JNK/P38/MAPKs signaling pathways [PMID:34484390]. It induces apoptosis via DNA fragmentation and increased caspase-3 activity through intrinsic and extrinsic pathways, and may down-regulate telomerase activation [PMID:20979698, PMID:15135654]. In osteosarcoma cells, it is associated with the modulation of mitochondrial fission/fusion machinery and induction of mitochondrial dysfunction [PMID:27776427, PMID:24836433]. Anti-inflammatory effects are facilitated by reducing pro-inflammatory cytokine production and inhibiting prostaglandin and nitric oxide synthesis [PMID:40271556].
Preuves cliniques
Preuve BNon-alcoholic steatohepatitis (NASH)
A placebo-controlled double-blind randomized trial was conducted to test if P. urinaria was superior to placebo in improving histological NAFLD activity score over 24 weeks [PMID:23034128].
Demonstrates potential in the treatment of liver disease, though detailed pharmacological mechanisms remain scarce [PMID:39185304].
Preuve DCancer
In vitro and in vivo evidence shows reduction of cell viability in various cancer lines and suppression of tumor development in mice [PMID:20979698, PMID:27776427].
Preuve DAndrogen-derived alopecia
Extract showed hair regrowth activity in mice at 5 mg/mouse/d and inhibited 5α-reductase [PMID:30068884].
Sécurité et effets indésirables
A therapeutic dose of P. urinaria extract did not show any toxicological phenomenon in mice [PMID:19386480].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (mice/broilers), and reviews, with one randomized controlled trial for NASH. Overall strength is low to moderate, predominantly preclinical.
Sources PubMed
1.PMID: 34484390 (2021) — A Review: Mechanism of Phyllanthus urinaria in Cancers-NF-κB, P13K/AKT, and MAPKs Signaling Activation. · Evidence-based complementary and alternative medicine : eCAM
2.PMID: 12877924 (2003) — Lignans from Phyllanthus urinaria. · Phytochemistry
3.PMID: 39185304 (2024) — A review of Phyllanthus urinaria L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma. · Frontiers in pharmacology
4.PMID: 20979698 (2010) — Anti-cancer effects of Phyllanthus urinaria and relevant mechanisms. · Chang Gung medical journal
5.PMID: 36635908 (2023) — Agent in Urgent Need of Clinical Practice: Corilagin.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 36684764 (2022) — Application of chloroplast genome in the identification of Phyllanthus urinaria and its common adulterants. · Frontiers in plant science
7.PMID: 30327602 (2018) — A Review of the Phytochemistry and Pharmacology of Phyllanthus urinaria L. · Frontiers in pharmacology
8.PMID: 30068884 (2018) — Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase. · Biological & pharmaceutical bulletin
9.PMID: 40271556 (2025) — An Updated Review on the Anti-Inflammatory Potential of Phyllanthus Genus. · Chemistry & biodiversity
10.PMID: 18157836 (2008) — Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo. · Hepatology (Baltimore, Md.)
11.PMID: 15135654 (2004) — Phyllanthus urinaria induces the Fas receptor/ligand expression and ceramide-mediated apoptosis in HL-60 cells. · Life sciences
12.PMID: 27776427 (2016) — Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery. · The American journal of Chinese medicine
13.PMID: 19386480 (2009) — Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. · Phytomedicine : international journal of phytotherapy and phytopharmacology
14.PMID: 35503410 (2023) — Metabolomics analysis of differential chemical constituents and α-glucosidase inhibiting activity of Phyllanthus urinaria L. root, stem, leaf and fruit. · Natural product research
15.PMID: 19295228 (2009) — Phyllanthus urinaria increases apoptosis and reduces telomerase activity in human nasopharyngeal carcinoma cells. · Forschende Komplementarmedizin (2006)
16.PMID: 24836433 (2014) — Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins. · Mitochondrion
17.PMID: 26220282 (2015) — Inhibitory effect of Phyllanthus urinaria L. extract on the replication of lamivudine-resistant hepatitis B virus in vitro. · BMC complementary and alternative medicine
18.PMID: 23034128 (2013) — Treatment of non-alcoholic steatohepatitis with Phyllanthus urinaria: a randomized trial. · Journal of gastroenterology and hepatology
19.PMID: 37716546 (2023) — Towards the development of analytical monograph specifications for the quality assessment of the medicinal plant Phyllanthus urinaria. · Phytochemistry
20.PMID: 37459860 (2023) — Anthelmintic Activities of Extract and Ellagitannins from Phyllanthus urinaria against Caenorhabditis elegans and Zoonotic or Animal Parasitic Nematodes. · Planta medica