Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Cajanus cajan work for sickle cell disease?
Cajanus cajan contains bioactive compounds called cajanol and cajanin, which are flavonoids that demonstrate antisickling activity in laboratory studies. These compounds appear to inhibit polymerization of hemoglobin S, potentially reducing sickle cell crisis frequency and severity. Research also indicates antioxidant and anti-inflammatory properties that may support red blood cell membrane stability. However, clinical evidence remains limited (Evidence Level C), and more human trials are needed to confirm these mechanisms. Traditional use in Caribbean and African medicine has focused on leaf extracts for managing sickle cell symptoms.
Does Cajanus cajan interact with any medications?
Limited research exists on specific drug interactions with Cajanus cajan. As a legume containing significant protein and iron, it may theoretically affect absorption of certain medications, including thyroid medications and some antibiotics. The plant's potential effects on blood parameters suggest caution when combined with anticoagulants or anti-platelet drugs. Patients taking immunosuppressants should consult healthcare providers before use. Always inform your physician about herbal supplements, as interactions may not be well-documented (Evidence Level D). Those with known legume allergies should avoid this herb entirely.
What is the recommended dosage for Cajanus cajan leaf tea?
Traditional and folk medicine preparations typically use 5-10 grams of dried Cajanus cajan leaves prepared as a tea, taken twice daily for conditions like anemia or general wellness. The seeds are consumed as a food staple in many cultures and do not have a strict medicinal dosage. Standardized extracts are not widely available, making precise dosing challenging. Evidence for therapeutic dosing remains limited (Evidence Level C). Consult a qualified healthcare provider or medical herbalist for personalized recommendations, especially if treating specific conditions like sickle cell disease.
Is Cajanus cajan safe during pregnancy?
Cajanus cajan is considered unsafe during pregnancy, particularly at medicinal doses of leaf preparations. Traditional use and limited pharmacological data suggest the plant may affect uterine function or fetal development when consumed in therapeutic amounts. While the seeds are commonly eaten as food in many cultures, pregnant women should avoid concentrated leaf extracts, teas, or root preparations. Those with legume allergies should also avoid this herb due to potential cross-reactivity. Always consult a qualified healthcare provider before using any herbal remedy during pregnancy or breastfeeding (Evidence Level D).
What are the traditional uses of Cajanus cajan for anemia?
Cajanus cajan has been used traditionally in Caribbean and African folk medicine to treat anemia, largely due to its notable iron content and protein-rich seeds. The leaves are prepared as teas or decoctions to help support red blood cell production and address fatigue associated with anemia. Some traditional practitioners combine it with other iron-rich herbs for enhanced effects. While the nutritional content supports these uses, clinical evidence specifically validating efficacy for anemia treatment remains limited (Evidence Level C). Those with diagnosed anemia should work with healthcare providers for appropriate treatment.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Cajanus cajan, known as pigeon pea, is a commercial legume crop grown in sub-tropical and semi-arid tropical regions, valued for its nutritional and medicinal properties [PMID:36296470, PMID:35110974].
Contexte
Cajanus cajan (pigeon pea) is a member of the Fabaceae family and is an important orphan crop primarily grown by smallholder farmers in Africa and India [PMID:36296470, PMID:32020732]. It is utilized as a food and feed source, particularly for protein supplementation in cereal-based diets [PMID:35110974].
Usages traditionnels
It is used in folk medicine to treat various disorders, including toothache, dizziness, diabetes, stomachache, female ailments, and chronic infections [PMID:36296470]. It is also recognized as a traditional Chinese medicinal plant [PMID:39598829].
Composés actifs
Active compounds include stilbenes (such as cajaninstilbene acid) [PMID:39598829, PMID:35662649], isocoumarins (cajanolactone B, C, D1, and D2) [PMID:38444970], phthalide derivatives (Cajanthalides A, B, and C) [PMID:40032233], isoflavonoids, anthraquinones, and pterocarpanoids [PMID:35448466]. Leaf extracts also contain flavones, flavonols, flavanones, isoflavones, coumarins, and chalcones [PMID:33830649].
Mécanisme d'action
Cajaninstilbene acid (CSA) and its derivatives are investigated for multi-therapeutic actions, including antioxidant, anti-inflammatory, and immune regulation activities [PMID:39598829]. Certain peptides from pigeon pea protein inhibit renin and angiotensin-I-converting enzyme (ACE) activities [PMID:36250929].
Preuves cliniques
Preuve DHyperglycemia/Diabetes
Extract of germinated pigeon pea reduced fasting blood glucose levels in alloxan-induced diabetic rats [PMID:27625782]. Red gram prebiotics decreased serum glucose levels by 14.92% compared to a control group in Wistar NIN rats [PMID:28837379].
Preuve DHyperlipidemia
Red gram prebiotics decreased serum triglycerides by 32.76% compared to a control group in Wistar NIN rats [PMID:28837379].
Preuve DBacterial Infection (S. aureus)
Secondary metabolites from seeds demonstrated in vitro antibacterial properties against multidrug-resistant Staphylococcus aureus [PMID:35448466].
Preuve DFungal Infection
Cajanthalide B exhibited moderate antifungal activity against C. neoformans, C. albicans, and M. furfur with MIC values of 40 μg/mL [PMID:40032233].
Sécurité et effets indésirables
Legumes, including red gram (Cajanus cajan), contain IgE binding proteins that may cause allergenic responses ranging from mild skin reactions to life-threatening anaphylactic reactions [PMID:22555630].
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D), with some review articles (Level C) summarizing traditional uses and phytochemical profiles. No human clinical trials (Level B) or meta-analyses (Level A) were provided.
Sources PubMed
1.PMID: 31893440 (2020) — Updates on Legume Genome Sequencing. · Methods in molecular biology (Clifton, N.J.)
2.PMID: 38444970 (2024) — Four new isocoumarins from Cajanus cajan. · RSC advances
3.PMID: 36296470 (2022) — Revisiting the Nutritional, Chemical and Biological Potential of Cajanus cajan (L.) Millsp. · Molecules (Basel, Switzerland)
4.PMID: 22555630 (2013) — A comprehensive review of legume allergy. · Clinical reviews in allergy & immunology
5.PMID: 32020732 (2020) — Trait associations in the pangenome of pigeon pea (Cajanus cajan). · Plant biotechnology journal
6.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
10.PMID: 36241771 (2022) — Cajanus cajan shows multiple novel adaptations in response to regular mechanical stress. · Journal of plant research
11.PMID: 39598829 (2024) — Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review. · Molecules (Basel, Switzerland)
12.PMID: 38564410 (2024) — Pigeon pea crop stage strongly influences plant susceptibility to Helicoverpa armigera (Lepidoptera: Noctuidae). · Journal of economic entomology
13.PMID: 35366099 (2022) — Comparative analysis of herbivory responsive miRNAs to delineate pod borer (Helicoverpa armigera) resistance mechanisms in Cajanus cajan and its wild relative Cajanus scarabaeoides. · Plant cell reports
14.PMID: 35448466 (2022) — Antibiotic Isoflavonoids, Anthraquinones, and Pterocarpanoids from Pigeon Pea (Cajanus cajan L.) Seeds against Multidrug-Resistant Staphylococcus aureus. · Metabolites
15.PMID: 36250929 (2022) — Pigeon pea penta- and hexapeptides with antioxidant properties also inhibit renin and angiotensin-I-converting enzyme activities. · Journal of food biochemistry
16.PMID: 37751043 (2023) — Identification, characterization, and comprehensive expression profiling of floral master regulators in pigeon pea (Cajanus cajan [L.] Millspaugh). · Functional & integrative genomics
17.PMID: 28837379 (2018) — Hypolipidemic Effect of Red Gram (Cajanus cajan L.) Prebiotic Oligosaccharides in Wistar NIN Rats. · Journal of dietary supplements
18.PMID: 35662649 (2022) — Stilbenes from the leaves of Cajanus cajan and their in vitro anti-inflammatory activities. · Fitoterapia
19.PMID: 40032233 (2025) — Three new antifungal phthalide derivatives from Cajanus cajan. · Fitoterapia
20.PMID: 37430905 (2022) — Substituting Whole Wheat Flour with Pigeon Pea (Cajanus cajan) Flour in Chapati: Effect on Nutritional Characteristics, Color Profiles, and In Vitro Starch and Protein Digestion. · Foods (Basel, Switzerland)
21.PMID: 33560125 (2021) — Absorption, Metabolism, and Excretion of Cajaninstilbene Acid. · Journal of agricultural and food chemistry
22.PMID: 39597614 (2024) — Microbes in Agriculture: Prospects and Constraints to Their Wider Adoption and Utilization in Nutrient-Poor Environments. · Microorganisms
23.PMID: 32564200 (2021) — Bioenvironmental Trace Elements in Warm Climatic Plant, Pigeon Pea (Cajanus cajan). · Biological trace element research
24.PMID: 42328141 (2026) — Techno-functional and sensory properties of pigeon pea-rice protein blends for beverage applications. · Journal of food science and technology
25.PMID: 33830649 (2021) — Components identification and isomers differentiation in pigeon pea (Cajanus cajan L.) leaves by LC-MS. · Journal of separation science
26.PMID: 34557206 (2021) — Genomic Diversity of Pigeon Pea (Cajanus cajan L. Millsp.) Endosymbionts in India and Selection of Potential Strains for Use as Agricultural Inoculants. · Frontiers in plant science
27.PMID: 34249596 (2021) — Induction of moisture stress tolerance by Bacillus and Paenibacillus in pigeon pea (Cajanus cajan. L). · 3 Biotech
28.PMID: 35538269 (2022) — Genome-wide transcriptome analysis and characterization of the cytochrome P450 flavonoid biosynthesis genes in pigeon pea (Cajanus cajan). · Planta
29.PMID: 27625782 (2016) — Germinated Pigeon Pea (Cajanus cajan): a novel diet for lowering oxidative stress and hyperglycemia. · Food science & nutrition