How does Calamintha nepeta work for digestion?

Calamintha nepeta contains volatile oils, primarily pulegone and isomenthone, which function as carminatives. These compounds help relax smooth muscle in the gastrointestinal tract, reducing spasms and facilitating the expulsion of gas. This mechanism explains its traditional use for relieving digestive discomfort, bloating, and flatulence. Evidence level: C/Traditional.

Does Calamintha nepeta interact with medications?

Calamintha nepeta contains pulegone, which may interact with drugs metabolized by the liver. Pulegone can inhibit specific cytochrome P450 enzymes, potentially altering the breakdown and effectiveness of various pharmaceutical drugs. Individuals taking prescription medications should consult a healthcare provider before use. Evidence level: C.

What is the recommended dosage for Calamintha nepeta?

The standard adult dosage for Calamintha nepeta is 2-4 grams of dried herb daily or 1-2 ml of tincture. It is typically prepared as a tea or taken as a liquid extract to support digestive health. Users should adhere to recommended amounts to avoid potential side effects like gastrointestinal upset. Evidence level: Traditional.

Is Calamintha nepeta safe during pregnancy?

No, Calamintha nepeta is unsafe during pregnancy due to its pulegone content. Pulegone is known to stimulate uterine contractions and poses a risk of liver toxicity. Pregnant women, as well as individuals with epilepsy or kidney disease, should strictly avoid this herb. Evidence level: C.

What is Calamintha nepeta used for?

Calamintha nepeta is traditionally used in European folk medicine to treat digestive disorders, respiratory infections, and fever. It is valued as a carminative for relieving gas and bloating, and is also used for headaches. While these applications are historically established, modern clinical evidence supporting them is limited. Evidence level: C.

Calamintha nepeta (Calamintha nepeta): Benefits, Dosage, Safety & Evidence

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 29 articles PubMed · modèle : gemma4:31b

Résumé

Calamintha nepeta is a Mediterranean Lamiaceae plant used in traditional medicine, characterized by essential oils with antioxidant and anti-inflammatory properties [PMID:34916937, PMID:38140425].

Contexte

Calamintha nepeta (also referred to as Clinopodium nepeta) is an aromatic herb from the Lamiaceae family found in Mediterranean regions [PMID:34916937, PMID:38140425].

Usages traditionnels

It has been used in traditional medicine to alleviate rheumatic disorders [PMID:34916937].

Composés actifs

The plant contains essential oils and phenolic compounds [PMID:29794251]. Major constituents vary by chemotype and origin, including pulegone (the most abundant monoterpene), piperitenone oxide, piperitenone, isomenthone, 1,8-cineole, and trans-isopulegone [PMID:20981614, PMID:34916937]. It also contains sterols, with stigmast-5-en-3β-ol identified as a major constituent in subsp. glandulosa [PMID:21861645].

Mécanisme d'action

Aqueous extracts exhibit radical scavenging and chelating activities [PMID:39434513]. The plant's polyphenols are noted for potential antiaggregatory effects in the prevention of thrombus formation [PMID:31639083].

Preuves cliniques

Preuve DInflammation

Extracts produced a 49% inhibition in carrageenan-induced paw oedema [PMID:22186311]

Preuve DVasorelaxation

Decoction extracts demonstrated vasorelaxant effects on thoracic aortic rings from rats [PMID:39434513]

Preuve DCancer (In vitro)

Essential oils showed an antiproliferative effect against human breast tumour cell lines [PMID:31377137]

Preuve DCandida

Essential oils of subsp. glandulosa exhibit antifungal activity [PMID:28134788]

Sécurité et effets indésirables

Aqueous extracts showed no toxicity in Artemia salina lethality bioassays [PMID:39434513]. However, essential oils showed high activity (toxicity) against A. salina [PMID:31377137].

Synthèse des preuves

The current evidence is limited to in vitro studies, animal models, and phytochemical analyses (Level D); there are no clinical trials or systematic reviews available for this herb.

Sources PubMed

1.PMID: 39434513 (2024) — In vitro biological activities of Calamintha nepeta L. aqueous extracts. · Journal of applied biomedicine
2.PMID: 34916937 (2021) — Anti-Hyperalgesic Properties of Menthol and Pulegone. · Frontiers in pharmacology
3.PMID: 21861645 (2012) — Comparative chemical composition and antioxidant activity of Calamintha nepeta (L.) Savi subsp. glandulosa (Req.) Nyman and Calamintha grandiflora (L.) Moench (Labiatae). · Natural product research
4.PMID: 31639083 (2019) — Antithrombotic activity of flavonoids and polyphenols rich plant species. · Acta pharmaceutica (Zagreb, Croatia)
5.PMID: 20981614 (2010) — Chemical composition and biological assays of essential oils of Calamintha nepeta (L.) Savi subsp. nepeta (Lamiaceae). · Natural product research

Calamintha nepeta

Sources et citations

Calculer une dose sûre de Calamintha nepeta

Cleome Gynandra

Costmary

Marjoram Egyptian

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Calamintha nepeta

Sources et citations

Calculer une dose sûre de Calamintha nepeta

Plantes associées

Cleome Gynandra

Costmary

Marjoram Egyptian

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales