Calliandra surinamensis (Calliandra surinamensis): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Calliandra surinamensis work to lower blood sugar?

Calliandra surinamensis contains active compounds such as flavonoids and alkaloids that are believed to regulate glucose metabolism. While the exact mechanism requires further study, preliminary research suggests these constituents may inhibit glucose absorption in the intestine or enhance insulin sensitivity. Evidence Level C indicates these findings are currently supported by animal studies and traditional use rather than human clinical trials.

Does Calliandra surinamensis interact with diabetes medications?

Yes, Calliandra surinamensis poses a significant risk of interaction with antidiabetic drugs. Because the herb naturally lowers blood glucose, taking it concurrently with medications like metformin or insulin can result in additive effects, causing dangerous hypoglycemia. Patients on prescribed diabetes medication should avoid this herb or seek strict medical supervision to prevent blood sugar from dropping too low.

What is the traditional dosage for Calliandra surinamensis bark?

The traditional adult dosage for Calliandra surinamensis involves preparing a decoction using 5 to 10 grams of dried bark. This preparation is boiled in water and consumed to address symptoms of diabetes or fever. Due to the potential for side effects like hypoglycemia, users should exercise caution and avoid exceeding this amount, as standardized clinical dosing guidelines have not been established.

Is Calliandra surinamensis safe to use during pregnancy?

No, Calliandra surinamensis is considered unsafe during pregnancy. The presence of alkaloids and uterine-stimulating properties presents a risk of miscarriage or fetal harm. Furthermore, the herb's ability to lower blood sugar levels can be dangerous for a pregnant woman. Health practitioners advise complete avoidance of this botanical remedy while pregnant or breastfeeding due to insufficient safety data.

What are the potential side effects of Calliandra surinamensis?

The most notable side effect of Calliandra surinamensis is hypoglycemia, or abnormally low blood sugar, which can result in dizziness, confusion, and sweating. Gastrointestinal upset, including nausea and stomach cramping, has also been reported. These effects are largely due to the plant's active compounds, and users should monitor their glucose levels to avoid acute adverse reactions.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 6 articles PubMed · modèle : gemma4:31b

Résumé

Calliandra surinamensis is a Neotropical species of the Leguminosae family with documented ethnobotanical value and pharmacological properties [PMID:41751987, PMID:19419029].

Contexte

Calliandra surinamensis is a species within the genus Calliandra (Leguminosae: Mimosoideae), which consists of over 200 species primarily located in the Neotropics [PMID:41751987, PMID:19419029].

Usages traditionnels

The species holds significant ethnobotanical value, although specific traditional applications are not detailed in the provided abstracts [PMID:41751987].

Composés actifs

The species produces secondary metabolites including galloylated flavonoids, phenolic acids, and triterpenes [PMID:41751987]. A specific lectin named CasuL (an acidic oligomeric protein of 48kDa) has been isolated from its leaf pinnulae [PMID:28174088].

Mécanisme d'action

The lectin CasuL promotes cell signaling and cytokine production (specifically IL-2 and TNF-α) and increases cytosolic ROS levels in mice splenocytes without inducing apoptosis or necrosis [PMID:30118881]. It also demonstrates cytotoxicity against specific cancer cell lines [PMID:28174088].

Preuves cliniques

Preuve DCancer (Leukemic K562 and Breast T47D cells)

The isolated lectin CasuL demonstrated cytotoxicity with IC50 values of 67.04±5.78µg/mL for K562 cells and 58.75±2.5µg/mL for T47D cells [PMID:28174088].

Preuve DBovine and Caprine Mastitis (Staphylococcus isolates)

CasuL inhibited the growth of Staphylococcus isolates (MIC 3.75 to 15 µg/ml) and showed synergistic effects when combined with tetracycline or ampicillin [PMID:31099495].

Preuve DBacterial Infection (E. coli)

Biosynthesized silver nanoparticles using C. surinamensis leaf extract showed strong antibacterial properties with a zone of inhibition of 19.09 mm [PMID:38744691].

Sécurité et effets indésirables

CasuL did not reduce the viability of human peripheral blood mononuclear cells [PMID:28174088]. Biosynthesized silver nanoparticles (b-Cs-AgNPs) were compatible with human normal kidney cells and chicken embryos, and did not trigger skin inflammatory responses in a rat model [PMID:38744691].

Synthèse des preuves

The current evidence consists of review articles and in vitro/in vivo laboratory studies (Level C and D). There are no clinical trials or meta-analyses available for this herb.

Sources PubMed

1.PMID: 41751987 (2026) — Genus Calliandra-Calliandra portoricensis, Calliandra haematocephala, Calliandra surinamensis: A Journey from Traditional Knowledge to Modern Experimental Studies in Disease Prevention and Treatment. · International journal of molecular sciences
2.PMID: 28174088 (2017) — CasuL: A new lectin isolated from Calliandra surinamensis leaf pinnulae with cytotoxicity to cancer cells, antimicrobial activity and antibiofilm effect. · International journal of biological macromolecules
3.PMID: 31099495 (2019) — Looking for alternative treatments for bovine and caprine mastitis: Evaluation of the potential of Calliandra surinamensis leaf pinnulae lectin (CasuL), both alone and in combination with antibiotics. · MicrobiologyOpen
4.PMID: 38744691 (2024) — Biosynthesized silver nanoparticles prevent bacterial infection in chicken egg model and mitigate biofilm formation on medical catheters. · Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
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Calliandra surinamensis

Sources et citations

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