Casimiroa Edulis (Casimiroa edulis): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Casimiroa edulis work as a sedative?

Casimiroa edulis contains active compounds including casimirosin, N-benzyllinoleamide, and various alkaloids that act on the central nervous system to produce sedative effects. These compounds appear to modulate neurotransmitter activity, particularly GABA pathways, which help calm neural activity and promote sleep. The flavonoid content, including zapotin, may contribute additional calming effects. Research on the precise mechanism remains limited (Evidence Level C), but traditional use and preliminary studies support its sedative and hypotensive properties.

Does Casimiroa edulis interact with any medications?

Yes, Casimiroa edulis can interact with several medication classes. Due to its sedative properties, it should not be combined with CNS depressants, benzodiazepines, barbiturates, or alcohol, as this may cause excessive sedation or respiratory depression. Its hypotensive effects may dangerously amplify blood pressure medications, leading to severe hypotension. Always consult a healthcare provider before combining with any prescription medications, especially sedatives, antihypertensives, or antidepressants.

What is the recommended dosage of Casimiroa edulis for sleep?

The traditional adult dosage for Casimiroa edulis leaf tea is 2-3 grams of dried leaf steeped in hot water, taken before bedtime for insomnia. Due to its potent sedative effects and potential for respiratory depression at higher doses, use should be under medical supervision. Dosage has not been standardized in clinical trials (Evidence Level C), so individuals should start with lower amounts and avoid exceeding recommended doses. Professional guidance is strongly advised.

Is Casimiroa edulis safe to take during pregnancy?

No, Casimiroa edulis is considered unsafe during pregnancy. The plant contains potent bioactive compounds that may affect uterine tone and fetal development. Its sedative properties and potential for hypotension pose risks to both maternal and fetal health. Pregnant women, those planning pregnancy, and breastfeeding mothers should avoid this herb entirely. The seeds and leaves contain concentrated active compounds that may cross the placental barrier and cause adverse outcomes.

What are the side effects of Casimiroa edulis?

Casimiroa edulis can cause several side effects, particularly when taken in high doses. Common effects include excessive drowsiness, dizziness, and low blood pressure (hypotension). In overdose situations, it may cause respiratory depression, which can be life-threatening. Users should avoid driving or operating machinery after taking this herb. Those with existing low blood pressure or respiratory conditions should exercise particular caution. Seek immediate medical attention if breathing difficulties occur.

What conditions is Casimiroa edulis traditionally used for?

Casimiroa edulis has been used traditionally in Mexico and Central America for treating insomnia, hypertension, anxiety, and fever. The seeds and leaves are the primary parts used medicinally, valued for their potent sedative and blood pressure-lowering properties. Indigenous medicine has employed this plant for centuries as a natural sleep aid and calming agent. However, clinical evidence supporting these uses remains limited (Evidence Level C), and traditional applications should not replace professional medical treatment.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Casimiroa edulis, commonly known as white sapote, is a tropical fruiting tree native to Mexico and Central America used traditionally to treat hypertension and anxiety [PMID: 25036684, 39966363].

Contexte

Casimiroa edulis is a species of tropical fruiting tree in the Rutaceae family, native to eastern Mexico and Central America south to Costa Rica [PMID: 25036684]. It is widely distributed in Mexico's tropical and subtropical areas [PMID: 39966363].

Usages traditionnels

Decoctions of the leaves and seeds are traditionally used as a tea to lower blood pressure [PMID: 21726621, 24309287] and the leaf decoction is also used to treat anxiety [PMID: 39966363].

Composés actifs

The plant contains phenolic compounds including herniarin, imperatorin, 8-geranyloxypsoralen, and methoxylated flavones such as casedulones A and B [PMID: 24309287, 35245426]. Other identified constituents include synephrine acetonide, N-monomethylhistamine, N,N-dimethylhistamine, proline, N-methylproline, gamma-aminobutyric acid, and casimiroedine [PMID: 10075120]. Volatiles include styrene, myrcene, 1,2,4-trimethylbenzene, 1,8-cineole, and linalool [PMID: 17195665].

Mécanisme d'action

Vasorelaxation may occur via nitric oxide (NO) release and calcium channel blockade [PMID: 39966363]. Some effects are mediated through H1- and H2-histaminergic receptors [PMID: 1896518, 2062952]. Casedulones A and B suppress MMP9 expression by inhibiting the JAK/STAT3 and TNFα-dependent pathways [PMID: 38910321].

Preuves cliniques

Preuve DHypertension

Extracts from leaves and seeds induced vasorelaxation in rat arterial tissues [PMID: 21726621, 21236328] and produced marked hypotension in anesthetized dogs and rats [PMID: 1896518, 2062952].

Preuve DAnxiety

Aqueous leaf extract increased open arms exploration in male Wistar rats, indicating anxiolytic-like action [PMID: 15182911].

Preuve DEpilepsy/Seizures

Aqueous leaf extracts elicited abolition of maximal electroshock and metrazole-induced seizures in rats [PMID: 7623484, 10624888].

Preuve DDiabetic Male Reproductive Dysfunction

Leaf extract improved reproductive impairment in streptozotocin-induced diabetic male rats by modulating testosterone levels and testicular enzymes [PMID: 41076815].

Preuve DSilver Nanoparticle Toxicity

Leaf extracts ameliorated biomarkers of oxidative stress, repaired DNA damage, and mitigated apoptosis-mediated neurotoxicity in mice exposed to silver nanoparticles [PMID: 32754950, 36518464, 36518381].

Sécurité et effets indésirables

Dichloromethane extract was evaluated for acute and sub-acute toxicity following OECD protocols [PMID: 39966363]. High doses (45-55 mg/kg) of aqueous leaf extract reduced locomotion in rats [PMID: 15182911].

Synthèse des preuves

The current evidence is based entirely on preclinical studies (animal models and in vitro assays), primarily focusing on vasorelaxant, anxiolytic, and antioxidant properties. There are no human clinical trials provided.

Sources PubMed

1.PMID: 35875242 (2022) — Physicochemical, functional and sensory properties of probiotic yoghurt flavored with white sapote fruit (Casimiroa edulis). · Journal of food science and technology
2.PMID: 38073662 (2023) — Effect of using dried white sapote fruit (Casimiroa edulis) on the quality characteristics of bio-low-fat goat milk yoghurt drink. · Saudi journal of biological sciences
3.PMID: 21726621 (2011) — Age-dependent vasorelaxation of Casimiroa edulis and Casimiroa pubescens extracts in rat caudal artery in vitro. · Journal of ethnopharmacology
4.PMID: 37851183 (2023) — Immunostimulant effects of diet supplementation with yellow (Pouteria campechiana), white (Casimiroa edulis), and black (Diospyros digyna) sapote nanocapsules on laying hens: in vitro and in vivo study. · Tropical animal health and production
5.PMID: 17195665 (2006)

Casimiroa Edulis

Sources et citations

Calculer une dose sûre de Casimiroa Edulis

Rauvolfia vomitoria

Evodia Rutaecarpa

Loranthus Parasite

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Casimiroa Edulis

Sources et citations

Calculer une dose sûre de Casimiroa Edulis

Plantes associées

Rauvolfia vomitoria

Evodia Rutaecarpa

Loranthus Parasite

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales