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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Casimiroa edulis
Arbre fruitier originaire du Mexique et d'Amérique centrale dont les graines et les feuilles contiennent des composés sédatifs puissants utilisés traditionnellement pour le sommeil et l'hypertension.
Casimiroa edulis (white sapote) is a fruit tree native to Mexico and Central America, whose seeds and leaves contain sedative and antihypertensive compounds including casimirosin, zapotin, and N-benzyllinoleamide. Traditionally used for insomnia, hypertension, and anxiety, modern evidence (Grade C) supports its sedative and hypotensive effects, though clinical data remain limited. The herb's primary active constituents are alkaloids and flavonoids that modulate GABAergic and cardiovascular pathways.
Casimirosin and N-benzyllinoleamide act as positive allosteric modulators of GABA-A receptors, enhancing chloride ion conductance and producing sedative and anxiolytic effects. Zapotin, a polymethoxyflavone, inhibits angiotensin-converting enzyme (ACE) and promotes nitric oxide-mediated vasodilation, contributing to antihypertensive activity. Additionally, alkaloids in the leaves may block calcium channels, further reducing vascular resistance. These mechanisms are supported by in vitro and limited in vivo studies, but human pharmacokinetic data are sparse.
Arbre fruitier originaire du Mexique et d'Amérique centrale dont les graines et les feuilles contiennent des composés sédatifs puissants utilisés traditionnellement pour le sommeil et l'hypertension.
Casimiroa edulis (white sapote) is a fruit tree native to Mexico and Central America, whose seeds and leaves contain sedative and antihypertensive compounds including casimirosin, zapotin, and N-benzyllinoleamide. Traditionally used for insomnia, hypertension, and anxiety, modern evidence (Grade C) supports its sedative and hypotensive effects, though clinical data remain limited. The herb's primary active constituents are alkaloids and flavonoids that modulate GABAergic and cardiovascular pathways.
Casimirosin and N-benzyllinoleamide act as positive allosteric modulators of GABA-A receptors, enhancing chloride ion conductance and producing sedative and anxiolytic effects. Zapotin, a polymethoxyflavone, inhibits angiotensin-converting enzyme (ACE) and promotes nitric oxide-mediated vasodilation, contributing to antihypertensive activity. Additionally, alkaloids in the leaves may block calcium channels, further reducing vascular resistance. These mechanisms are supported by in vitro and limited in vivo studies, but human pharmacokinetic data are sparse.