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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Chaenomeles speciosa is an edible medicinal plant from the Rosaceae family traditionally used in China to treat various ailments [PMID:38062238, PMID:30622618].
Contexte
Chaenomeles plants, including C. speciosa, are deciduous spiny shrubs in the Rosaceae family found and cultivated worldwide, with China serving as a primary origin and distribution hub [PMID:38062238, PMID:28895387].
Usages traditionnels
Traditionally used in China to treat rheumatism, cholera, dysentery, enteritis, beriberi, scurvy [PMID:38062238, PMID:24649061], anemia, gout, and cardiovascular diseases [PMID:28895387].
Composés actifs
The fruit contains a diversity of phytochemicals including phenolics, flavonoids, terpenoids, organic acids, phenylpropanoids, benzoic acid derivatives, biphenyls, oxylipins, alkaloids, and vitamin C [PMID:38062238, PMID:30622618, PMID:28895387]. Specific identified compounds include chlorogenic acid, neo-chlorogenic acid, rutin, quercetin, ent-Epicatechin, and mairin [PMID:38892026, PMID:37178981]. It also contains polysaccharides and lignin-carbohydrate complexes [PMID:38998935, PMID:36336153].
Mécanisme d'action
C. speciosa fruit extracts may lower uric acid by inhibiting xanthine oxidase (XOD) and regulating protein expression of URAT1, GLUT9, OAT1, and OAT3 in the kidneys [PMID:38393010, PMID:39339463]. Butylchlorogenate from C. speciosa may alleviate ulcerative colitis by suppressing NLRP3 inflammasome activation and remodeling intestinal homeostasis [PMID:41005055]. Polysaccharides may act via the MAPK pathway to reduce pro-inflammatory cytokines [PMID:35401173].
Preuves cliniques
Preuve DHyperuricemia
Total fruit extract (CSFTE) reduced serum uric acid, creatinine, and blood urea nitrogen levels in rats [PMID:38393010]
Preuve DRheumatoid Arthritis/Joint Inflammation
Polysaccharides demonstrated analgesic and anti-arthritic activity, reducing paw edema in CFA-induced rats [PMID:35401173]; network pharmacology suggests chondroprotective effects via targets like AKT1 and IL-6 [PMID:37178981]
Preuve DDepression
Fruit extract (CSFE) improved depressive-like behaviors in corticosterone-induced mice, reducing immobility in tail suspension and forced swim tests [PMID:38892026]
Preuve DUlcerative Colitis
Butylchlorogenate from C. speciosa shows potential in managing UC by suppressing NLRP3 inflammasome activation [PMID:41005055]
Synthèse des preuves
The current evidence is primarily based on in vitro studies and animal models (Level D) and literature reviews (Level C), demonstrating significant pharmacological potential for anti-inflammatory, hypouricemic, and antidepressant effects, but lacks human clinical trials.
Sources PubMed
1.PMID: 38062238 (2023) — Phytochemistry and pharmacology of plants in the genus Chaenomeles. · Archives of pharmacal research
2.PMID: 30622618 (2018) — Phytochemical and Pharmacological Properties of Chaenomeles speciosa: An Edible Medicinal Chinese Mugua. · Evidence-based complementary and alternative medicine : eCAM
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— Butylchlorogenate from Chaenomeles speciosa alleviates ulcerative colitis via suppressing NLRP3 inflammasome activation and remodeling intestinal homeostasis.
· Phytomedicine : international journal of phytotherapy and phytopharmacology
6.PMID: 38892026 (2024) — Antidepressant-like Effects of Chinese Quince (Chaenomeles sinensis) Fruit Based on In Vivo and Molecular Docking Studies. · International journal of molecular sciences
7.PMID: 24649061 (2014) — Chaenomeles speciosa: A review of chemistry and pharmacology. · Biomedical reports
8.PMID: 38393010 (2024) — Anti-Hyperuricemic Effects of Extracts from Chaenomeles speciosa (Sweet) Nakai Fruits on Hyperuricemic Rats. · Metabolites
9.PMID: 36336153 (2022) — Structural variation of lignin-carbohydrate complexes (LCC) in Chinese quince (Chaenomeles sinensis) fruit as it ripens. · International journal of biological macromolecules
10.PMID: 35401173 (2022) — Analgesic and Anti-Arthritic Activities of Polysaccharides in Chaenomeles speciosa. · Frontiers in pharmacology
11.PMID: 37178981 (2023) — Exploring the chondroprotective effect of Chaenomeles speciosa on Glucose-6-Phosphate Isomerase model mice using an integrated approach of network pharmacology and experimental validation. · Journal of ethnopharmacology
12.PMID: 39339463 (2024) — Bioassay-Guided Isolation and Identification of Xanthine Oxidase Inhibitory Constituents from the Fruits of Chaenomeles speciosa (Sweet) Nakai. · Molecules (Basel, Switzerland)