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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Melia toosendan
Fruit du Melia sinensis utilisé en TCM pour déplacer le Qi du foie, arrêter la douleur, expulser les parasites et traiter les affections dues à un blocage du Qi du foie entraînant des douleurs hypochondriatiques.
Chuan Lian Zi (Melia toosendan) is the fruit of the Sichuan Melia tree, traditionally used in Chinese medicine to soothe liver qi stagnation, alleviate hypochondriac and hernia pain, and expel intestinal parasites. Its primary active compounds include toosendanin, melianin, and nimbolinins, which exhibit analgesic, anti-inflammatory, antifungal, and antiparasitic properties. Modern research supports its use in pain management and parasitic infections, though clinical evidence remains limited (Level C).
Toosendanin, a triterpenoid, acts as a calcium channel blocker at presynaptic nerve terminals, inhibiting neurotransmitter release and thereby producing muscle relaxation and analgesia. It also induces apoptosis in parasitic cells by disrupting mitochondrial membrane potential and increasing reactive oxygen species. The limonoids and nimbolinins exert anti-inflammatory effects via suppression of NF-κB and COX-2 pathways, while antifungal activity is attributed to inhibition of fungal cell wall synthesis and membrane integrity. Hepatotoxicity at high doses is linked to oxidative stress and mitochondrial dysfunction in hepatocytes.
Fruit du Melia sinensis utilisé en TCM pour déplacer le Qi du foie, arrêter la douleur, expulser les parasites et traiter les affections dues à un blocage du Qi du foie entraînant des douleurs hypochondriatiques.
Chuan Lian Zi (Melia toosendan) is the fruit of the Sichuan Melia tree, traditionally used in Chinese medicine to soothe liver qi stagnation, alleviate hypochondriac and hernia pain, and expel intestinal parasites. Its primary active compounds include toosendanin, melianin, and nimbolinins, which exhibit analgesic, anti-inflammatory, antifungal, and antiparasitic properties. Modern research supports its use in pain management and parasitic infections, though clinical evidence remains limited (Level C).
Toosendanin, a triterpenoid, acts as a calcium channel blocker at presynaptic nerve terminals, inhibiting neurotransmitter release and thereby producing muscle relaxation and analgesia. It also induces apoptosis in parasitic cells by disrupting mitochondrial membrane potential and increasing reactive oxygen species. The limonoids and nimbolinins exert anti-inflammatory effects via suppression of NF-κB and COX-2 pathways, while antifungal activity is attributed to inhibition of fungal cell wall synthesis and membrane integrity. Hepatotoxicity at high doses is linked to oxidative stress and mitochondrial dysfunction in hepatocytes.