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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Aristolochia cymbifera
Liane brésilienne utilisée en médecine populaire contre les morsures de serpent, la fièvre et les troubles digestifs ; contient des acides aristolochiques — néphrotoxiques, emploi avec extrême prudence.
Cipó Mil Homens (Aristolochia cymbifera) is a Brazilian vine traditionally used for snakebite, fever, and digestive issues, but its clinical use is severely limited due to the presence of aristolochic acids, which are potent nephrotoxins and carcinogens. The plant contains aristolochic acid I and II, aristolactam, beta-sitosterol, and flavonoids, with some evidence of antimicrobial, analgesic, and anti-inflammatory activities. However, due to its high toxicity, internal use is not recommended, and any therapeutic application must be approached with extreme caution.
Aristolochic acids (AA-I and AA-II) are metabolically activated to form DNA adducts, leading to mutations in the TP53 gene and promoting carcinogenesis, particularly in the urothelial tract. These compounds also cause proximal tubular necrosis and interstitial fibrosis in the kidneys via oxidative stress and mitochondrial dysfunction. The anti-inflammatory and analgesic effects may involve inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) pathways, as well as modulation of NF-κB signaling, but these benefits are outweighed by the severe toxicity. Flavonoids and beta-sitosterol contribute minor antioxidant and anti-inflammatory actions, but their concentrations are insufficient to mitigate the aristolochic acid risk.
Liane brésilienne utilisée en médecine populaire contre les morsures de serpent, la fièvre et les troubles digestifs ; contient des acides aristolochiques — néphrotoxiques, emploi avec extrême prudence.
Cipó Mil Homens (Aristolochia cymbifera) is a Brazilian vine traditionally used for snakebite, fever, and digestive issues, but its clinical use is severely limited due to the presence of aristolochic acids, which are potent nephrotoxins and carcinogens. The plant contains aristolochic acid I and II, aristolactam, beta-sitosterol, and flavonoids, with some evidence of antimicrobial, analgesic, and anti-inflammatory activities. However, due to its high toxicity, internal use is not recommended, and any therapeutic application must be approached with extreme caution.
Aristolochic acids (AA-I and AA-II) are metabolically activated to form DNA adducts, leading to mutations in the TP53 gene and promoting carcinogenesis, particularly in the urothelial tract. These compounds also cause proximal tubular necrosis and interstitial fibrosis in the kidneys via oxidative stress and mitochondrial dysfunction. The anti-inflammatory and analgesic effects may involve inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) pathways, as well as modulation of NF-κB signaling, but these benefits are outweighed by the severe toxicity. Flavonoids and beta-sitosterol contribute minor antioxidant and anti-inflammatory actions, but their concentrations are insufficient to mitigate the aristolochic acid risk.