Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Cissampelos pareira contains isoquinoline alkaloids including pelosine, curine, hayatidine, and cycleanine, which exert curare-like muscle relaxant effects by blocking neuromuscular transmission. These compounds also demonstrate anti-inflammatory and diuretic properties through modulation of inflammatory pathways and increased renal blood flow. The plant's effects on smooth muscle help explain its traditional use for urinary and reproductive disorders. Evidence level: C.
Does Cissampelos pareira interact with any medications?
Yes, Cissampelos pareira may interact with muscle relaxants and medications affecting neuromuscular function. The plant contains curare-like alkaloids that enhance muscle relaxation, potentially increasing the effects of prescription muscle relaxants, anesthetics, or medications used during surgery. This interaction could lead to excessive muscle weakness or respiratory depression. Patients should inform healthcare providers of use before surgery or when taking muscle relaxants. Evidence level: C.
What is the recommended dosage of Cissampelos pareira?
The traditional adult dosage of Cissampelos pareira is 3-6 grams of dried root powder prepared as a decoction, taken once or twice daily. Alternatively, 300mg of standardized extract may be taken twice daily. Dosage should be adjusted based on individual tolerance and the condition being treated. Due to muscle relaxant effects, start with lower doses and avoid exceeding recommended amounts. Evidence level: Traditional/C.
Is Cissampelos pareira safe during pregnancy?
No, Cissampelos pareira is contraindicated during pregnancy. The plant contains uterine-stimulating compounds and curare-like alkaloids that may cause uterine contractions and potentially lead to miscarriage or premature labor. Traditional use has included this herb for inducing labor and addressing reproductive disorders in non-pregnant women. Pregnant women and those attempting to conceive should avoid all preparations of this herb. Evidence level: Traditional/C.
What is Cissampelos pareira used for treating?
Cissampelos pareira is traditionally used for urinary tract infections, kidney stones, and bladder disorders due to its diuretic and anti-inflammatory properties. It is also employed for female reproductive conditions including menstrual disorders and as a uterine tonic. Additional traditional applications include fever reduction, wound healing, and treatment of gastrointestinal complaints. Research supporting these uses is limited, with evidence rated at level C. Evidence level: C/Traditional.
What are the side effects of Cissampelos pareira?
Cissampelos pareira may cause gastrointestinal disturbances including nausea, vomiting, and diarrhea, particularly at higher doses. The curare-like alkaloids can produce muscle relaxation and weakness, which may be problematic at excessive doses. Some users report dizziness or fatigue. These effects are dose-dependent and typically resolve upon discontinuation. Long-term safety data is lacking, so extended use should be monitored by a healthcare professional. Evidence level: C/Traditional.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Cissampelos pareira is a medicinal climber-plant of the Menispermaceae family used traditionally in various systems, including Ayurveda, for treating a wide range of inflammatory, infectious, and psychopharmacological disorders [PMID:33485976, PMID:33964866].
Contexte
Cissampelos pareira is a medicinal climber-plant belonging to the Menispermaceae family [PMID:33485976]. It is recognized in classical texts as Laghupatha [PMID:28827957].
Usages traditionnels
Traditionally used for treating ulcers, wounds, rheumatism, fever, asthma, cholera, diarrhoea, inflammation, snakebite, malaria, rabies, blood purification [PMID:33485976], as well as cough, obesity, dysentery, jaundice, and heart, blood pressure, and skin-related problems [PMID:24997389]. It is also used in Ayurveda as a cardiotonic and diuretic [PMID:26647106], for urinary problems [PMID:23661865], and by ethnic minorities in India for psychopharmacological disorders [PMID:33964866].
Composés actifs
The plant contains alkaloids (including isoquinoline alkaloids such as magnoflorine, magnocurarine, cissamine, curine, hayatinine, cycleanine, and a cularine-type alkaloid [PMID:29126362, PMID:36148597], as well as a pyrrole alkaloid called cissampeline [PMID:31135214]), polyhydroxylated oleanane triterpenoids (cissatriterpenoid A-C) [PMID:35208972], flavonoids, terpenoids, steroids, saponins, and gums [PMID:24716177, PMID:25425762].
Mécanisme d'action
In silico analysis suggests interactions between its compounds and the GABAA receptor [PMID:36148597], PPAR gamma [PMID:36518544], and antimalarial targets including Pfdihydrofolate reductase, PfcGMP-dependent protein kinase, and Pfprolyl-tRNA synthetase [PMID:36848855].
Preuves cliniques
Preuve DCardiac Hypertrophy
Root extract ameliorated thyroxin-induced cardiac hypertrophy in rats [PMID:26647106]
Preuve DAnxiety and Depression
Hydro-alcoholic leaf extract exhibited anti-depressant, anxiolytic, and skeletal muscle relaxant activity in mice/rats [PMID:33964866, PMID:24716177]
Preuve DPain and Inflammation
Root and ethanol extracts showed significant analgesic, anti-inflammatory, and antipyretic activity in animal models [PMID:17240096, PMID:25425762, PMID:28827957]
Preuve DArthritis
Root extract showed dose-dependent protective effects against complete Freund's adjuvant induced arthritis in mice [PMID:17240096]
Preuve DCancer
Cissatriterpenoid 3 showed cytotoxic activity against A549, SMMC-7721, MCF-7, and SW480 cell lines [PMID:35208972]; methanol extract showed antitumor activity against Dalton's Lymphoma Ascites in mice [PMID:25210304]
Preuve DFertility
Sécurité et effets indésirables
Acute oral toxicity tests in mice showed no mortality or behavioral changes at doses up to 2000 mg/kg [PMID:33964866, PMID:18280070]. Subacute toxicity studies in rats (1-2 g/kg/day for 28 days) showed no mortality or significant changes in blood chemistry [PMID:18280070]. The oral LD50 in mice was reported as 7.3 g/kg for leaf extract [PMID:17324540].
Synthèse des preuves
The current evidence is based primarily on in vitro studies and animal models (Level D), demonstrating broad pharmacological potential, but lacks human clinical trials.
Sources PubMed
1.PMID: 33485976 (2021) — Cissampelos pareira L.: A review of its traditional uses, phytochemistry, and pharmacology. · Journal of ethnopharmacology
2.PMID: 35208972 (2022) — Cytotoxic Polyhydroxylated Oleanane Triterpenoids from Cissampelos pareira var. hirsuta. · Molecules (Basel, Switzerland)
3.PMID: 24997389 (2014) — From arrow poison to herbal medicine--the ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae). · Journal of ethnopharmacology
4.PMID: 26647106 (2016) — Cissampelos pareira Linn. ameliorates thyroxin-induced cardiac hypertrophy in rats. · Journal of ethnopharmacology
5.PMID: 33964866 (2021) — Anti-depressant, Anxiolytic, and the Muscle Relaxant Activity of Hydroalcoholic Extract of Cissampelos pareira Linn. Leaves.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Methanolic leaf extract exhibited antifertility effects in female albino mice by altering the estrous cycle and reducing litter numbers [PMID:17324540]
Preuve DDengue
Methanolic extract of aerial parts exhibited in vitro and in vivo anti-dengue activity against four DENV serotypes [PMID:34912307]
Preuve DSARS-CoV-2
Extract showed anti-SARS-CoV-2 activity in vitro [PMID:35459166]
Preuve DDiuresis
Alcoholic root extract exhibited diuretic activity in albino rats [PMID:24995192]
· Central nervous system agents in medicinal chemistry
6.PMID: 34912307 (2021) — Cocculus hirsutus-Derived Phytopharmaceutical Drug Has Potent Anti-dengue Activity. · Frontiers in microbiology
7.PMID: 35459166 (2022) — Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies. · BMC complementary medicine and therapies
8.PMID: 23661865 (2012) — Phytochemical investigation and pharmacognostic standardization of Cissampelos pareira root. · Ancient science of life
9.PMID: 28827957 (2016) — Comparative antipyretic and analgesic activities of Cissampelos pareira Linn. and Cyclea peltata (Lam.) Hook. F. & Thomas. · Ayu
10.PMID: 28943445 (2018) — The effects of Cissampelos pareira extract on envenomation induced by Bothropsdiporus snake venom. · Journal of ethnopharmacology
11.PMID: 29126362 (2019) — Bioactive isoquinoline alkaloids from Cissampelos pareira †. · Natural product research
12.PMID: 36148597 (2024) — A cularine-type isoquinoline alkaloid from the root part of Cissampelos pareira. · Natural product research
13.PMID: 17324540 (2007) — Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice. · Journal of ethnopharmacology
14.PMID: 40689394 (2025) — Phytochemical Screening and In Vitro Antioxidant and Anticancer Evaluation of Stem and Leaf Extracts of Cissampelos pareira L. · Mediators of inflammation
15.PMID: 25210304 (2014) — Anticancer activity of cissampelos pareira against dalton's lymphoma ascites bearing mice. · Pharmacognosy magazine
16.PMID: 17240096 (2007) — Antinociceptive and antiarthritic activity of Cissampelos pareira roots. · Journal of ethnopharmacology
17.PMID: 18280070 (2008) — Toxicological screening of traditional medicine Laghupatha (Cissampelos pareira) in experimental animals. · Journal of ethnopharmacology
18.PMID: 24995192 (2014) — Evaluation of diuretic activity of alcoholic extract of roots of cissampelos pareira in albino rats. · Journal of clinical and diagnostic research : JCDR
19.PMID: 41003161 (2025) — Community Structure Diversity of Endophytic Fungi in Cissampelos pareira from Different Habitats and Their α-Glucosidase Inhibitory Activity. · Journal of fungi (Basel, Switzerland)
20.PMID: 20582188 (2010) — Comparative phytochemical investigation of the sources of ayurvedic drug patha: a chromatographic fingerprinting analysis. · Indian journal of pharmaceutical sciences
21.PMID: 31135214 (2021) — A new pyrrole alkaloid from the roots of Cissampelos pareira. · Natural product research
22.PMID: 35163898 (2022) — Insecticidal Activity of Extracts, Fractions, and Pure Molecules of Cissampelos pareira Linnaeus against Aphid, Aphis craccivora Koch. · Molecules (Basel, Switzerland)
23.PMID: 21179368 (2010) — Antioxidant and immunomodulatory activity of the alkaloidal fraction of Cissampelos pareira linn. · Scientia pharmaceutica
24.PMID: 24716177 (2013) — Effect of Cissampelos Pareira Leaves on Anxiety-like Behavior in Experimental Animals. · Journal of traditional and complementary medicine
25.PMID: 25425762 (2014) — Phytochemical and Pharmacological Investigation of Ethanol Extract of Cissampelos pareira. · Indian journal of pharmaceutical sciences
26.PMID: 36848855 (2023) — Bisbenzylisoquinolines from Cissampelos pareira L. as antimalarial agents: Molecular docking, pharmacokinetics analysis, and molecular dynamic simulation studies. · Computational biology and chemistry