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CL
Not CommonRésumée par IA
Cistus Ladanifer Herb
Cistus ladanifer
Résine aromatique utilisée dans la médecine ancienne
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Cistus ladanifer, commonly known as gum rockrose, is a Mediterranean shrub valued for its essential oils and labdanum resin, which exhibit antimicrobial, antioxidant, and anti-inflammatory properties [PMID:41302483, PMID:35684251].
Contexte
Cistus ladanifer is a dominant perennial shrub endemic to the western Mediterranean region [PMID:29218421, PMID:30232598]. It is well-adapted to Mediterranean climates and is noted for its resistance to pests, diseases, and extreme environmental factors [PMID:30232598].
Usages traditionnels
In folk medicine, it is traditionally used for wounds, ulcers, and skin ailments such as psoriasis and eczema [PMID:36243295]. Ethnobotanical reports also describe its use in managing hyperglycemia and mental illnesses [PMID:38792084], and it is employed in Moroccan traditional medicine [PMID:39791951].
Composés actifs
Major constituents include essential oils containing α-pinene, viridiflorol, and camphene [PMID:41302483, PMID:33049951]. Labdanum resin contains labdane-type diterpenoids, methylated flavonoids, and phenylpropanoids [PMID:35684251, PMID:38792084]. Other identified compounds include 2,2,6-trimethylcyclohexanone (proposed as a taxonomic marker) [PMID:29218421], condensed tannins [PMID:31627117], and phenolic compounds such as p-cresol, 2-phenylethanol, and 3-phenyl-1-propanol [PMID:34205022].
Mécanisme d'action
The herb's essential oils and resin demonstrate antioxidant, antimicrobial, and anti-inflammatory activities [PMID:41302483, PMID:35684251]. Labdanum resin has shown potential for inhibiting α-glucosidase (anti-diabetic activity) [PMID:38792084]. In animal models, it has been observed to increase α-tocopherol concentration in muscle, which protects against lipid oxidation [PMID:32172003].
Preuves cliniques
Preuve DBacterial and Fungal Infections
Essential oils showed powerful antibacterial activity against Staphylococcus aureus, Escherichia coli, and Acinetobacter baumannii, as well as inhibitory effects on yeasts and molds [PMID:34685879, PMID:36767025].
Preuve DPain (Analgesia)
Ethanolic extract of Moroccan C. ladanifer demonstrated analgesic power in mice using formalin-induced paw-licking and acetic acid-provoked writhing models [PMID:37488755].
Preuve DSkin Care (Cosmeceutical)
Labdanum absolute showed UV-protection, antioxidant, anti-elastase, anti-inflammatory, and antimicrobial activities in vitro [PMID:35684251].
Preuve DHyperglycemia
Labdanum resin demonstrated potential antidiabetic activity via inhibition of α-glucosidase [PMID:38792084].
Preuve DViral Infections
In vitro and in silico analysis identified potential antiviral activity against Herpes Simplex Virus 1 and SARS-CoV-2 (Delta and Omicron variants) [PMID:39791951].
Sécurité et effets indésirables
Acute toxicity studies in mice using ethanolic extract showed no mortality or clinical symptoms at doses up to 5,000 mg/kg BW [PMID:37488755]. However, a case of contact dermatitis has been reported [PMID:11683839].
Synthèse des preuves
The current evidence is primarily based on in vitro studies, animal models, and chemical profiling (Level D). There are no human clinical trials or systematic reviews provided to establish clinical efficacy in humans.
Sources PubMed
1.PMID: 29218421 (2018) — Cistus ladanifer (Cistaceae): a natural resource in Mediterranean-type ecosystems. · Planta
2.PMID: 41302483 (2025) — Cistus ladanifer L.: Essential Oils, Volatiles, By-Products, and Their Biological Properties. · Molecules (Basel, Switzerland)
3.PMID: 30232598 (2018) — Neglected Mediterranean plant species are valuable resources: the example of Cistus ladanifer. · Planta
4.PMID: 36767025 (2023) — Antimicrobial Properties of Essential Oils Obtained from Autochthonous Aromatic Plants. · International journal of environmental research and public health
5.PMID: 35684251 (2022) — Labdanum Resin from Cistus ladanifer L.: A Natural and Sustainable Ingredient for Skin Care Cosmetics with Relevant Cosmeceutical Bioactivities.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 37746842 (2023) — Spatial Variation in Yield, Chemical Composition, and Phytotoxic Activity of Cistus ladanifer Essential Oils. · Chemistry & biodiversity
7.PMID: 38792084 (2024) — Labdanum Resin from Cistus ladanifer L. as a Source of Compounds with Anti-Diabetic, Neuroprotective and Anti-Proliferative Activity. · Molecules (Basel, Switzerland)
8.PMID: 31474477 (2019) — Labdanum and Labdanes of Cistus creticus and C. ladanifer: Anti-Borrelia activity and its phytochemical profiling✰. · Phytomedicine : international journal of phytotherapy and phytopharmacology
9.PMID: 33049951 (2020) — Pullulan Films Containing Rockrose Essential Oil for Potential Food Packaging Applications. · Antibiotics (Basel, Switzerland)
10.PMID: 34205022 (2021) — Phytotoxic Activity of p-Cresol, 2-Phenylethanol and 3-Phenyl-1-Propanol, Phenolic Compounds Present in Cistus ladanifer L. · Plants (Basel, Switzerland)
11.PMID: 36904046 (2023) — Evaluation of Propiophenone, 4-Methylacetophenone and 2',4'-Dimethylacetophenone as Phytotoxic Compounds of Labdanum Oil from Cistus ladanifer L. · Plants (Basel, Switzerland)
12.PMID: 37111859 (2023) — Shrub Invasion Overrides the Effect of Imposed Drought on the Photosynthetic Capacity and Physiological Responses of Mediterranean Cork Oak Trees. · Plants (Basel, Switzerland)
13.PMID: 37488755 (2023) — Study of the Analgesic Potential of the Ethanolic Extract of Moroccan Cistus ladanifer L. · Cardiovascular & hematological disorders drug targets
14.PMID: 30083180 (2018) — Terpenoid Emissions of Two Mediterranean Woody Species in Response to Drought Stress. · Frontiers in plant science
15.PMID: 31334698 (2019) — Pseudomonas edaphica sp. nov., isolated from rhizospheric soil of Cistus ladanifer L. in Spain. · International journal of systematic and evolutionary microbiology
16.PMID: 27137636 (2012) — Seasonal Variation of Cistus ladanifer L. Diterpenes. · Plants (Basel, Switzerland)
17.PMID: 32121584 (2020) — Characterization of Cistus × incanus L. and Cistus ladanifer L. Extracts as Potential Multifunctional Antioxidant Ingredients for Skin Protecting Cosmetics. · Antioxidants (Basel, Switzerland)
18.PMID: 39791951 (2025) — Uncovering Antiviral Potential of Cistus Ladanifer Extracts Against Herpes Simplex Virus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 by In Vitro and In Silico Analysis. · Chemistry & biodiversity
19.PMID: 32392769 (2020) — Effect of Leaf Litter from Cistus ladanifer L. on the Germination and Growth of Accompanying Shrubland Species. · Plants (Basel, Switzerland)
20.PMID: 31627117 (2020) — Inclusion of the aerial part and condensed tannin extract from Cistus ladanifer L. in lamb diets - Effects on growth performance, carcass and meat quality and fatty acid composition of intramuscular and subcutaneous fat. · Meat science
21.PMID: 36243295 (2023) — Thymus mastichina (L.) L. and Cistus ladanifer L. for skin application: chemical characterization and in vitro bioactivity assessment. · Journal of ethnopharmacology
22.PMID: 34685879 (2021) — Chemical Composition, Antibacterial and Antifungal Activity of the Essential Oil from Cistus ladanifer L. · Plants (Basel, Switzerland)
23.PMID: 33801870 (2021) — Effects of Increasing Doses of Condensed Tannins Extract from Cistus ladanifer L. on In Vitro Ruminal Fermentation and Biohydrogenation. · Animals : an open access journal from MDPI
25.PMID: 32231039 (2020) — Fatty Acid Content and Composition of the Morphological Fractions of Cistus Ladanifer L. and Its Seasonal Variation. · Molecules (Basel, Switzerland)
26.PMID: 27306827 (2016) — Effect of feeding lambs with a tanniferous shrub (rockrose) and a vegetable oil blend on fatty acid composition of meat lipids. · Animal : an international journal of animal bioscience
27.PMID: 32172003 (2020) — Increasing the α-tocopherol content and lipid oxidative stability of meat through dietary Cistus ladanifer L. in lamb fed increasing levels of polyunsaturated fatty acid rich vegetable oils. · Meat science
28.PMID: 27130817 (2017) — Modulation of in vitro rumen biohydrogenation by Cistus ladanifer tannins compared with other tannin sources. · Journal of the science of food and agriculture