Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Citrullus colocynthis
Cucurbit du désert d'Afrique du Nord et du Moyen-Orient avec des propriétés fortes laxatives ; utilisée en médecine traditionnelle.
Citrullus colocynthis, a desert cucurbit native to North Africa and the Middle East, is a potent purgative used traditionally for constipation, diabetes, and rheumatism. Its primary active compounds include colocynthin, elaterin, and cucurbitacins, which exert strong irritant effects on the gastrointestinal mucosa. Despite its traditional use, the herb has a narrow therapeutic window and significant toxicity, limiting its modern clinical application.
Colocynthin and cucurbitacins act as potent GI irritants, stimulating prostaglandin release and electrolyte secretion, leading to increased peristalsis and catharsis. These compounds also inhibit Na+/K+-ATPase and activate AMPK, contributing to potential antidiabetic effects by enhancing insulin sensitivity and glucose uptake. Anti-inflammatory actions are mediated through suppression of NF-κB and COX-2 pathways, but the high toxicity of cucurbitacins limits their therapeutic use.
Cucurbit du désert d'Afrique du Nord et du Moyen-Orient avec des propriétés fortes laxatives ; utilisée en médecine traditionnelle.
Citrullus colocynthis, a desert cucurbit native to North Africa and the Middle East, is a potent purgative used traditionally for constipation, diabetes, and rheumatism. Its primary active compounds include colocynthin, elaterin, and cucurbitacins, which exert strong irritant effects on the gastrointestinal mucosa. Despite its traditional use, the herb has a narrow therapeutic window and significant toxicity, limiting its modern clinical application.
Colocynthin and cucurbitacins act as potent GI irritants, stimulating prostaglandin release and electrolyte secretion, leading to increased peristalsis and catharsis. These compounds also inhibit Na+/K+-ATPase and activate AMPK, contributing to potential antidiabetic effects by enhancing insulin sensitivity and glucose uptake. Anti-inflammatory actions are mediated through suppression of NF-κB and COX-2 pathways, but the high toxicity of cucurbitacins limits their therapeutic use.