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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Colchicum autumnale
Belle plante à fleurs d'automne avec l'alcaloïde colchicine utilisée depuis l'Égypte ancienne pour le traitement de la goutte ; hautement toxique.
Colchicum autumnale (autumn crocus) is a highly toxic plant historically used for acute gout, with colchicine as its primary active alkaloid. Modern therapeutic use is limited to medically supervised gout treatment due to a narrow therapeutic index and severe toxicity. Key compounds include colchicine, demecolcine, and colchicoside, which exert antimitotic and anti-inflammatory effects.
Colchicine binds to tubulin, inhibiting microtubule polymerization and disrupting mitotic spindle formation, thereby arresting cell division and reducing neutrophil chemotaxis. It also suppresses inflammatory pathways by inhibiting NLRP3 inflammasome activation, decreasing IL-1β and TNF-α release. These actions underlie its antigout and anti-inflammatory properties, but high doses cause widespread cellular toxicity, particularly in rapidly dividing tissues like the gastrointestinal tract and bone marrow.
Belle plante à fleurs d'automne avec l'alcaloïde colchicine utilisée depuis l'Égypte ancienne pour le traitement de la goutte ; hautement toxique.
Colchicum autumnale (autumn crocus) is a highly toxic plant historically used for acute gout, with colchicine as its primary active alkaloid. Modern therapeutic use is limited to medically supervised gout treatment due to a narrow therapeutic index and severe toxicity. Key compounds include colchicine, demecolcine, and colchicoside, which exert antimitotic and anti-inflammatory effects.
Colchicine binds to tubulin, inhibiting microtubule polymerization and disrupting mitotic spindle formation, thereby arresting cell division and reducing neutrophil chemotaxis. It also suppresses inflammatory pathways by inhibiting NLRP3 inflammasome activation, decreasing IL-1β and TNF-α release. These actions underlie its antigout and anti-inflammatory properties, but high doses cause widespread cellular toxicity, particularly in rapidly dividing tissues like the gastrointestinal tract and bone marrow.