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Commiphora mukul
Résine ayurvédique étudiée cliniquement pour la réduction du cholestérol et la stimulation thyroïdienne.
Commiphora mukul (guggul) is a resinous Ayurvedic herb clinically studied for its lipid-lowering and thyroid-stimulating properties. Its primary active compounds, guggulsterones E and Z, modulate cholesterol metabolism via FXR antagonism and enhance thyroid function. Evidence is limited to small trials and traditional use, supporting its role in hyperlipidemia, obesity, arthritis, and hypothyroidism.
Guggulsterones act as antagonists of the farnesoid X receptor (FXR), increasing bile acid synthesis and promoting cholesterol clearance from the body. They also stimulate thyroid function by enhancing iodine uptake and thyroid peroxidase activity, leading to increased T3 and T4 production. Additionally, guggul exhibits anti-inflammatory effects through inhibition of NF-κB and COX-2 pathways, and may improve insulin sensitivity via PPAR-γ activation.
Résine ayurvédique étudiée cliniquement pour la réduction du cholestérol et la stimulation thyroïdienne.
Commiphora mukul (guggul) is a resinous Ayurvedic herb clinically studied for its lipid-lowering and thyroid-stimulating properties. Its primary active compounds, guggulsterones E and Z, modulate cholesterol metabolism via FXR antagonism and enhance thyroid function. Evidence is limited to small trials and traditional use, supporting its role in hyperlipidemia, obesity, arthritis, and hypothyroidism.
Guggulsterones act as antagonists of the farnesoid X receptor (FXR), increasing bile acid synthesis and promoting cholesterol clearance from the body. They also stimulate thyroid function by enhancing iodine uptake and thyroid peroxidase activity, leading to increased T3 and T4 production. Additionally, guggul exhibits anti-inflammatory effects through inhibition of NF-κB and COX-2 pathways, and may improve insulin sensitivity via PPAR-γ activation.