Copaifera reticulata (Copaifera reticulata): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does copaiba oil work as an anti-inflammatory?

Copaiba oil's primary active compound, beta-caryophyllene, acts as a selective CB2 receptor agonist. When CB2 receptors are activated, they modulate inflammatory and immune responses without producing psychoactive effects associated with CB1 receptor activation. Additional compounds like copalic acid and kaurenoic acid contribute antimicrobial and wound-healing properties. Evidence level C indicates this mechanism is supported by preclinical research and traditional use, with limited human clinical trials available.

Does copaiba oil interact with any medications?

Limited clinical data exists on copaiba oil drug interactions. Due to its potential effects on kidney function and gastrointestinal irritation, caution is warranted when combining with nephrotoxic medications or drugs affecting the digestive system. Copaiba's anti-inflammatory properties may theoretically enhance or interfere with other anti-inflammatory medications. Patients taking prescription medications should consult a healthcare provider before using copaiba supplements. Evidence level C reflects the lack of formal interaction studies.

What is the recommended dosage for copaiba oil capsules?

The standard adult dosage for copaiba oil capsules is 500mg taken twice daily. For topical applications, the oil can be applied directly to affected skin areas as needed. Dosage should not exceed recommendations, as higher amounts may cause gastrointestinal upset or kidney irritation. Individual needs may vary based on the condition being addressed. Consult a qualified healthcare provider for personalized dosing guidance, especially if taking other medications or supplements.

Is copaiba oil safe to use during pregnancy?

Copaiba oil is contraindicated during pregnancy and breastfeeding. Traditional evidence and available research suggest potential risks including uterine stimulation and possible fetal effects. The oil's active compounds may cross the placenta or affect fetal development. Pregnant individuals should avoid all forms of copaiba, including topical applications and oral supplements. Evidence level C indicates this recommendation is based on traditional knowledge and theoretical risks rather than extensive clinical studies.

How do Amazonian tribes traditionally use copaiba for wound healing?

Amazonian tribes, including the Kayapo, have used copaiba oleoresin for centuries as a wound healing remedy. The resin is applied topically to cuts, burns, and skin infections due to its antimicrobial and anti-inflammatory properties. Beta-caryophyllene and other sesquiterpenes help reduce inflammation while supporting tissue repair. Traditional use also includes internal applications for respiratory and urinary tract infections. Evidence level C reflects documentation of traditional practices and supporting preclinical research.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Copaifera reticulata is an Amazonian tree that produces an oil-resin used traditionally for its anti-inflammatory, antimicrobial, and healing properties [PMID:36234793, PMID:30472403].

Contexte

Copaifera reticulata Ducke is a species of the Copaifera genus (Leguminoseae/Fabaceae) abundant in several Brazilian states, including Pará, Amazonas, and Ceará [PMID:17446019, PMID:27118478]. The medicinal oil-resin is extracted from the trunk of the tree [PMID:37719866].

Usages traditionnels

In Brazilian folk medicine, it is used to treat skin and urinary tract infections, respiratory diseases, rheumatism, ulcers, tumors, and leishmaniasis wounds [PMID:30472403, PMID:28194218].

Composés actifs

The oleoresin is rich in sesquiterpenes and diterpenes [PMID:28160850]. Major sesquiterpenes include beta-caryophyllene, alpha-humulene, alpha-copaene, alpha-bergamotene, and delta-cadinene [PMID:17446019]. Diterpene components include copalic acid, ent-polyalthic acid, and kaurenoic acid [PMID:17446019, PMID:30590321, PMID:32431465].

Mécanisme d'action

Anti-inflammatory effects are associated with the reduction of nitric oxide (NO) and prostaglandin E2 (PGE2) production in macrophages [PMID:30590321]. Antinociceptive activity is mediated via opioid receptors, as the effect is completely inhibited by the antagonist naloxone [PMID:17029841]. Antiparasitic activity against Leishmania amazonensis is likely related to changes in the mitochondria and cell membrane [PMID:28194218].

Preuves cliniques

Preuve DInflammation/Edema

Reduced paw edema in arthritic rats [PMID:28322470] and reduced inflammatory profile in ligature-induced periodontitis in rats [PMID:36234793].

Preuve DWound Healing

Demonstrated healing ability in rat tongue injuries [PMID:28615025] and oral wounds [PMID:28635033].

Preuve DBacterial Infections

Antimicrobial activity against Gram-positive bacteria including Staphylococcus aureus and Enterococcus faecium [PMID:18545856, PMID:32431465].

Preuve DLeishmaniasis

C. reticulata oil showed antiproliferative activity against promastigote and amastigote forms of L. amazonensis [PMID:18775772].

Preuve DColon Carcinogenesis

Reduced DNA damage and pre-neoplastic lesions in a rat model of colon carcinogenesis [PMID:30590321].

Preuve DPain (Nociception)

Developed peripheral antinociceptive effects in animal models at doses of 30 to 150 mg/kg [PMID:17029841].

Sécurité et effets indésirables

In rat models, the oleoresin did not develop toxic effects at doses of 30-150 mg/kg [PMID:17029841]. It showed low cytotoxicity and genotoxicity [PMID:28194218].

Grossesse et allaitement

In a developmental toxicity study in rats, doses of 1000 and 1250 mg/kg bw/day were maternally toxic (reduced food intake and weight gain) and embryotoxic (lower fetal body weight and increased skeletal variations), though no fetal malformations occurred [PMID:21266184].

Synthèse des preuves

The evidence is primarily based on in vitro studies and animal models (Level D), demonstrating significant anti-inflammatory, antimicrobial, and wound-healing potential, though human clinical trials are lacking in the provided data.

Sources PubMed

1.PMID: 37719866 (2023) — Evaluation of the biological activities of Copaiba (Copaifera spp): a comprehensive review based on scientometric analysis. · Frontiers in pharmacology
2.PMID: 17446019 (2007) — Chemical composition and anti-inflammatory activity of copaiba oils from Copaifera cearensis Huber ex Ducke, Copaifera reticulata Ducke and Copaifera multijuga Hayne--a comparative study. · Journal of ethnopharmacology
3.PMID: 17029841 (2007) — Antinociceptive activity of Amazonian Copaiba oils. · Journal of ethnopharmacology
4.PMID: 36365477 (2022) — Design and Optimization of a Natural Medicine from Copaifera reticulata Ducke for Skin Wound Care. · Polymers
5.PMID: 28615025 (2017) — Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats' tongues.

Copaifera reticulata

Sources et citations

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