Crinum asiaticum (Crinum asiaticum): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Crinum asiaticum work to reduce inflammation and pain?

Crinum asiaticum exerts its medicinal effects primarily through bioactive alkaloids, specifically lycorine and crinamine. These compounds demonstrate anti-inflammatory and analgesic activity by inhibiting the production of inflammatory cytokines and mediators in the body. Research indicates that lycorine also possesses antiviral properties by interfering with viral replication cycles. While these mechanisms are observed in preclinical studies (Evidence Level C), they scientifically validate the plant's traditional use for treating infections, swelling, and pain.

Does Crinum asiaticum interact with blood pressure medications?

While specific clinical drug interaction trials are lacking (Evidence Level C), Crinum asiaticum poses theoretical risks regarding drug interactions. The herb contains alkaloids that may lower blood pressure, potentially enhancing the effects of antihypertensive medications and causing hypotension. Furthermore, due to the potential for central nervous system effects and toxicity, it should not be combined with sedatives or other neuroactive drugs without medical supervision. Patients on prescription medications should consult a healthcare provider before use.

What is the recommended dosage for Crinum asiaticum leaf tea?

The standard adult dosage for Crinum asiaticum leaf tea is 3 to 5 grams of dried leaf per cup, prepared as an infusion and taken twice daily. For external wound care, fresh leaves can be crushed and applied topically as a poultice. Internal ingestion of the bulb is strictly contraindicated due to high toxicity. These recommendations are based on traditional usage patterns, as clinical trials establishing standardized dosing are currently limited (Evidence Level C).

Is Crinum asiaticum safe to use during pregnancy?

No, Crinum asiaticum is considered unsafe during pregnancy and breastfeeding. The plant contains toxic alkaloids, including lycorine, which can cause severe side effects such as nausea, vomiting, and hypotension. More critically, these compounds may stimulate uterine contractions or cause fetal toxicity. Consequently, pregnant women and children should avoid all forms of this herb. This safety warning is based on the known pharmacology of its alkaloid constituents and traditional contraindications.

What are the side effects of taking Crinum asiaticum?

Common side effects of internal Crinum asiaticum use include nausea, vomiting, and dizziness, often resulting from the plant's alkaloid content. In susceptible individuals, ingestion may lead to hypotension (low blood pressure). The bulb is particularly toxic and can cause severe poisoning if ingested internally. Due to these potential adverse effects and limited clinical safety data (Evidence Level C), usage should be strictly limited to recommended dosages and supervised by a qualified practitioner.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Crinum asiaticum is a perennial bulbous herb used in traditional medicine for its anti-inflammatory, analgesic, and antimicrobial properties [PMID:38318065, 37593159].

Contexte

Crinum asiaticum (family Amaryllidaceae) is a perennial bulbous plant distributed in warmer regions, including Asia, Africa, and the Indian Ocean Islands [PMID:31527550, 37346329]. It is utilized both for its medicinal properties and as an ornamental plant [PMID:38318065, 41284967].

Usages traditionnels

In Thai traditional medicine, it is used to treat osteoarthritis and inflammation [PMID:37593159, 33574885]. In Korea and Malaysia, it has been used as a rheumatic remedy, anti-pyretic, anti-ulcer treatment, and for the alleviation of local pain and fever [PMID:18841306]. In Ghana, it is traditionally used for wound healing and upper respiratory tract infections [PMID:37346329].

Composés actifs

The plant contains Amaryllidaceae alkaloids, including lycorine, crinamine, norgalanthamine, and various new alkaloids such as crijaponine A and B [PMID:30963375, 18841306, 34915776]. Other identified compounds include polysaccharides (CAL-n), flavonoids, flavanols, and betulin [PMID:31889799, 31889798, 37346329, 34474490].

Mécanisme d'action

Anti-inflammatory effects are mediated through the inhibition of iNOS, PGE2, IL-6, and IL-8 [PMID:18841306], as well as the inhibition of NF-κB activation and p65 subunit phosphorylation [PMID:34474490]. Antipsychotic-like effects in animal models suggest potential antagonistic interaction with the dopamine D2 receptor and impact on glutamatergic signaling [PMID:39428354]. Some alkaloids exhibit acetylcholinesterase (AChE) inhibition [PMID:37889019, 41284967].

Preuves cliniques

Preuve DPsychosis (Animal Model)

Ethanolic extracts significantly reduced ketamine-induced hyperactivity and amphetamine-induced stereotypy [PMID:39428354]

Preuve DObesity (Animal Model)

Extracts suppressed body weight gain and epididymal fat accumulation in high-fat diet-induced and monogenic obese mice by downregulating PPARγ, C/EBPα, C/EBPβ, and aP2 [PMID:27470336]

Preuve DPulmonary Fibrosis (Animal Model)

Bulb extracts attenuated pulmonary fibrosis by downregulating pro-fibrotic and pro-inflammatory cytokines in bleomycin-induced mice [PMID:37346329]

Preuve DHepatotoxicity (Animal Model)

Norgalanthamine reversed increases in serum ALT, AST, and total bilirubin in CCl4-induced liver injury in mice [PMID:34915776]

Preuve DCancer (In Vitro)

Crinamine induced apoptosis and inhibited proliferation, migration, and angiogenesis in cervical cancer SiHa cells [PMID:31527550]; CAL-n affected the growth of HepG2 cells [PMID:31889799].

Preuve D

Sécurité et effets indésirables

Certain isolated alkaloids (compounds 39, 21, 22, and 35) demonstrated cytotoxic effects on cells despite their nitric oxide inhibitory activity [PMID:39756558].

Synthèse des preuves

The current evidence is primarily based on in vitro cell assays and in vivo animal models (Level D). There are no human clinical trials provided in the source abstracts.

Sources PubMed

1.PMID: 39428354 (2024) — Antipsychotic Activity of Ethanolic Extracts of Crinum asiaticum and Crinum defixum in Animal Models. · Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
2.PMID: 30963375 (2019) — Two new alkaloids from Crinum asiaticum var. japonicum. · Journal of natural medicines
3.PMID: 27558679 (2017) — Heterocyclic Amaryllidaceae Alkaloids: Biosynthesis and Pharmacological Applications. · Current topics in medicinal chemistry
4.PMID: 31889799 (2019) — Efficient polysaccharides from Crinum asiaticum L.'s structural characterization and anti-tumor effect. · Saudi journal of biological sciences
5.PMID: 37593159 (2023) — Formulation design and physicochemical evaluation of an anti-inflammatory hydrogel patch containing Crinum asiaticum L. extract.

Crinum asiaticum

Sources et citations

Calculer une dose sûre de Crinum asiaticum

Kunzea Ambigua

Purple Basil

Callistemon citrinus

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Crinum asiaticum

Sources et citations

Calculer une dose sûre de Crinum asiaticum

Plantes associées

Kunzea Ambigua

Purple Basil

Callistemon citrinus

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Sécurité et effets indésirables

Synthèse des preuves

Sources PubMed

Sources gouvernementales