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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Crotalaria spectabilis
Légume pan-tropical utilisé avec précaution en médecine populaire ; contient des alcaloïdes pyrrolizidiques hépatotoxiques.
Crotalaria spectabilis is a pantropical legume containing hepatotoxic pyrrolizidine alkaloids, primarily monocrotaline, which is used experimentally to induce pulmonary hypertension in animal models. Despite traditional use as an anthelmintic and fever remedy, internal consumption is lethal due to severe hepatotoxicity and pneumotoxicity.
Monocrotaline, a pyrrolizidine alkaloid, is bioactivated by hepatic cytochrome P450 enzymes (CYP3A4) to form reactive pyrrolic metabolites that covalently bind to cellular macromolecules, causing endothelial injury in pulmonary vasculature and hepatocytes. This leads to pulmonary arterial hypertension via increased vascular resistance and right ventricular hypertrophy, while hepatic damage involves sinusoidal obstruction syndrome and centrilobular necrosis.
Légume pan-tropical utilisé avec précaution en médecine populaire ; contient des alcaloïdes pyrrolizidiques hépatotoxiques.
Crotalaria spectabilis is a pantropical legume containing hepatotoxic pyrrolizidine alkaloids, primarily monocrotaline, which is used experimentally to induce pulmonary hypertension in animal models. Despite traditional use as an anthelmintic and fever remedy, internal consumption is lethal due to severe hepatotoxicity and pneumotoxicity.
Monocrotaline, a pyrrolizidine alkaloid, is bioactivated by hepatic cytochrome P450 enzymes (CYP3A4) to form reactive pyrrolic metabolites that covalently bind to cellular macromolecules, causing endothelial injury in pulmonary vasculature and hepatocytes. This leads to pulmonary arterial hypertension via increased vascular resistance and right ventricular hypertrophy, while hepatic damage involves sinusoidal obstruction syndrome and centrilobular necrosis.