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Curcuma caesia, or black turmeric, exerts its neurological effects primarily through volatile oils such as ar-turmerone and camphor. These compounds are believed to modulate neurotransmitter activity, potentially interacting with GABAergic pathways to reduce neuronal excitability. While these mechanisms are promising, current evidence is limited to preclinical studies (Evidence Level C), and more human trials are needed to fully understand its anticonvulsant action.
Does Curcuma caesia interact with epilepsy medications?
Yes, Curcuma caesia poses a significant risk of interaction with antiepileptic drugs. Because the herb possesses potential anticonvulsant properties, taking it alongside prescription seizure medications may potentiate effects or interfere with drug metabolism, leading to unpredictable seizure control. Patients taking medication for epilepsy should avoid this herb unless specifically monitored by a healthcare provider.
What is the recommended daily dosage for Curcuma caesia?
The standard adult dosage for Curcuma caesia rhizome powder is typically 1 to 3 grams daily. This amount is based on traditional Ayurvedic use and pharmacopoeia standards rather than robust clinical trials (Evidence Level C). It is generally taken orally with water. Users should start with the lower end of the range to assess tolerance, as higher doses may cause gastrointestinal upset.
Is Curcuma caesia safe to take during pregnancy?
No, Curcuma caesia is considered unsafe during pregnancy. The rhizome contains compounds like camphor and specific turmerones that may stimulate uterine contractions or pose toxicity risks to the developing fetus. Due to these potential emmenagogue effects and a lack of safety data, pregnant and breastfeeding women should strictly avoid supplementation with black turmeric.
What are the traditional uses of Curcuma caesia?
In Ayurvedic tradition, Curcuma caesia is primarily used for managing neurological conditions, epilepsy, and paralysis due to its neuroprotective reputation. It is also employed as a remedy for respiratory issues like asthma, rheumatic pain, and various skin diseases. While these uses are well-documented in traditional texts, scientific validation remains limited (Evidence Level C).
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Curcuma caesia, also known as black turmeric, is a medicinal herb from the Zingiberaceae family indigenous to India and Southeast Asia, recognized for its antioxidant, anti-inflammatory, and anticancer properties [PMID:37200789, 36704214, 41317210].
Contexte
Curcuma caesia (black turmeric) is a perennial herb characterized by bluish-black rhizomes and a camphoraceous aroma [PMID:41253921, 36704214]. It is an endangered species often collected from the wild in India and Southeast Asia [PMID:36292691, 37200789].
Usages traditionnels
In Indian and Ayurvedic medicine, it is traditionally used to treat cancer, bruises, inflammation, asthma, leukoderma, tumours, piles, and bronchitis, and is used as an aphrodisiac [PMID:23527894, 28962377, 17317653]. Tribal communities in North-East India also use it for the treatment of arthritis [PMID:41141599].
Composés actifs
The herb contains essential oils including camphor, ar-turmerone, (Z)-β-ocimene, ar-curcumene, 1,8-cineole, β-elemene, borneol, bornyl acetate, tropolone, ledol, β-elemenone, and α-bulnesene [PMID:36704214]. Other identified compounds include sesquiterpenes, monoterpenes, curzerenone, curcuzederone, germacrone, and zerumbone [PMID:41413130, 41253921, 31726856]. Notably, curcumin was not detected in C. caesia extracts [PMID:37592890].
Mécanisme d'action
C. caesia exhibits antioxidant activity by reducing oxidative stress [PMID:30767224]. It has demonstrated the ability to inhibit cyclooxygenase (COX-1 and COX-2) enzymes [PMID:23359084] and induce cell arrest at the G2/M phase and cellular apoptosis in cancer cells [PMID:28733192]. It also shows smooth muscle relaxant effects in the bronchioles and vasculature [PMID:17317653].
Preuves cliniques
Preuve BOral Submucous Fibrosis (OSMF)
Powdered C. caesia mixed with honey showed significantly more symptomatic improvement (reduction in burning sensation, improved cheek flexibility, mouth opening, and tongue protrusion) compared to C. longa [PMID:41148610]
Preuve DCancer (Ehrlich's ascites carcinoma in mice)
Methanol extract of rhizomes demonstrated antitumor activity, reducing tumor volume and weight [PMID:23527894]
Preuve DCervical Cancer (In vitro)
Methanolic extract induced DNA damage and apoptosis in HeLa and SiHa cell lines [PMID:41862889]
Preuve DBreast Cancer (In vitro)
Curcuzederone significantly inhibited the migration of triple-negative breast cancer cell line MDA-MB-231 [PMID:31726856]
Preuve DPeriodontal Infection (In vivo/In vitro)
A mucoadhesive gel encapsulating C. caesia leaf essential oil (with borneol as a major constituent) showed faster recovery of infection [PMID:40671580]
Sécurité et effets indésirables
Elemental analysis of rhizomes indicates that heavy metal levels are within the toxicity limits set by the World Health Organization, suggesting it is safe for medicinal purposes [PMID:38940214].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models, and one non-randomized clinical trial. While there is strong laboratory evidence for antioxidant and anticancer activity, clinical data is very limited.
Sources PubMed
1.PMID: 30767224 (2019) — Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy. · The Journal of pharmacy and pharmacology
2.PMID: 37200789 (2023) — 1H NMR-Based Metabolomics Approach Revealing Metabolite Variation of Black Turmeric (Curcuma caesia) Extracts and Correlation with Its Antioxidant and α-Glucosidase Inhibitory Activities. · Food technology and biotechnology
3.PMID: 32862164 (2020) — Effect of temperature and pressure on antimycobacterial activity of Curcuma caesia extract by supercritical fluid extraction method. · International journal of mycobacteriology
4.PMID: 23359084 (2013) — Functional food quality of Curcuma caesia, Curcuma zedoaria and Curcuma aeruginosa endemic to Northeastern India. · Plant foods for human nutrition (Dordrecht, Netherlands)
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— PGPR-mediated enhancement of growth, phytochemical diversity, and metabolites in black turmeric (Curcuma caesia Roxb).
· Frontiers in microbiology
6.PMID: 41141599 (2025) — Network pharmacology, molecular docking, molecular dynamics, and ADMET analysis of Curcuma caesia phytoconstituents against rheumatoid arthritis. · In silico pharmacology
7.PMID: 23527894 (2013) — Antitumor activity and antioxidant property of Curcuma caesia against Ehrlich's ascites carcinoma bearing mice. · Pharmaceutical biology
8.PMID: 41148610 (2025) — Comparing the Therapeutic Efficacy of Curcuma Caesia Roxb Over Curcuma Longa in Managing Oral Submucous Fibrosis: A Non-Randomized Clinical Trial. · Asian Pacific journal of cancer prevention : APJCP
9.PMID: 36704214 (2023) — A Comprehensive Review with Future Prospects on the Medicinal Properties and Biological Activities of Curcuma caesia Roxb. · Evidence-based complementary and alternative medicine : eCAM
10.PMID: 41413130 (2025) — NMR- and MS-based multiplex approach for comparative metabolome profiling of Curcuma caesia versus curcuma longa rhizomes and in relation to in vitro biological effects. · Scientific reports
11.PMID: 28962377 (2015) — Antioxidant and antimutagenic activity of Curcuma caesia Roxb. rhizome extracts. · Toxicology reports
12.PMID: 37592890 (2025) — A Validated High-Performance Thin-Layer Chromatography Technique for Routine Analysis of Curcumin in Four Different Species of Curcuma Viz. C. amada, C. caesia, C. longa and C. zedoaria. · Journal of chromatographic science
13.PMID: 41317210 (2025) — Evaluation of Phytochemical Variations Among the Different Genotypes of Black Turmeric (Curcuma caesia Roxb.). · Biochemical genetics
14.PMID: 38940214 (2024) — Pharmacognostical characterization, GC-MS profiling, and elemental analysis of Curcuma caesia Roxb. rhizomes for public health. · Journal of complementary & integrative medicine
15.PMID: 41253921 (2025) — Chemometric-guided diversity study of black turmeric essential oils from Eastern India revealed industrially feasible quality chemotypes with promising bioactivities. · Scientific reports
16.PMID: 31726856 (2021) — Bioactive chemical constituents from Curcuma caesia Roxb. rhizomes and inhibitory effect of curcuzederone on the migration of triple-negative breast cancer cell line MDA-MB-231. · Natural product research
17.PMID: 31691594 (2021) — Comparison of Curcuma Caesia extracts for bioactive metabolite composition, antioxidant and antimicrobial potential. · Natural product research
18.PMID: 36292691 (2022) — Identification and Registration for High-Yielding Strain through ST and MLT of Curcuma caesia Roxb. (Jor Lab KH-2): A High-Value Medicinal Plant. · Genes
19.PMID: 28733192 (2017) — Pharmacological evaluation of phytochemicals from South Indian Black Turmeric (Curcuma caesia Roxb.) to target cancer apoptosis. · Journal of ethnopharmacology
20.PMID: 26113180 (2015) — Comparative analysis of procoagulant and fibrinogenolytic activity of crude protease fractions of turmeric species. · Journal of ethnopharmacology
21.PMID: 31243828 (2020) — A 1 H-NMR spectroscopic method for the analysis of thermolabile chemical markers from the essential oil of black turmeric (Curcuma caesia) rhizome: application in post-harvest analysis. · Phytochemical analysis : PCA
22.PMID: 41862889 (2026) — Anticancer potential of Curcuma caesia: induction of DNA damage and apoptosis in cervical cancer. · BMC complementary medicine and therapies
23.PMID: 40671580 (2025) — PLGA-lecithin nanocarrier encapsulating curcuma caesia oil in a mucoadhesive gel: efficacy analysis against periodontal infections. · Journal of microencapsulation
24.PMID: 26941535 (2016) — Methanolic Extract of Curcuma caesia Roxb. Prevents the Toxicity Caused by Cyclophosphamide to Bone Marrow Cells, Liver and Kidney of Mice. · Pharmacognosy research
25.PMID: 40059601 (2026) — Identification of tropolone derivatives from black turmeric (Curcuma caesia Roxb.) essential oil and their application in postharvest management of mangoes (Mangifera indica L.). · Natural product research
26.PMID: 41678950 (2026) — Response surface methodology based Box-Behnken Design for statistical optimization of Curcuma caesia mediated copper oxide nanoparticles synthesis. · Biochemical and biophysical research communications
27.PMID: 31744446 (2020) — Study of Anti-oxidant, Anti-inflammatory, Genotoxicity, and Antimicrobial Activities and Analysis of Different Constituents found in Rhizome Essential Oil of Curcuma caesia Roxb., Collected from North East India. · Current pharmaceutical biotechnology
28.PMID: 25767317 (2015) — In vitro Antioxidant Potential in Sequential Extracts of Curcuma caesia Roxb. Rhizomes. · Indian journal of pharmaceutical sciences
29.PMID: 41636981 (2026) — Evaluation of antioxidant activities of bioactive peptides extracted from Curcuma longa and Curcuma caesia from South-eastern and North-Eastern India. · Probiotics and antimicrobial proteins
30.PMID: 17317653 (2006) — Preliminary mechanistic studies on the smooth muscle relaxant effect of hydroalcoholic extract of Curcuma caesia. · Journal of herbal pharmacotherapy