Devdaru (Cedrus deodara): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Devdaru work for inflammation and joint pain?

Devdaru contains bioactive sesquiterpenes including himachalol, atlantone, and cedrene, which demonstrate anti-inflammatory and analgesic properties in preclinical research. These compounds appear to inhibit pro-inflammatory mediators and may modulate pain signaling pathways. The herb also contains flavonoids contributing antioxidant activity. In Ayurvedic tradition, Devdaru is classified as a 'vedanasthapana' (pain-relieving) herb. Evidence level C indicates most data comes from laboratory and animal studies rather than human clinical trials.

Does Devdaru interact with any medications?

Limited research exists on Devdaru drug interactions. Theoretically, it may interact with antidiabetic medications due to potential effects on blood glucose, and with antiplatelet or anticoagulant drugs due to possible effects on bleeding parameters. Essential oil components may affect liver enzymes involved in drug metabolism. Patients taking prescription medications should consult a qualified healthcare provider before using Devdaru. No well-documented clinical interactions have been reported (Evidence level D).

What is the recommended dosage of Devdaru?

Traditional Ayurvedic practice recommends 2-3 grams of Devdaru bark prepared as a decoction, taken once or twice daily. For topical use, the essential oil must be diluted to 2-5% concentration in a carrier oil before application. Internal use of undiluted essential oil is not recommended due to potential toxicity. Dosage should be individualized based on constitution and condition. Consult a qualified practitioner for personalized guidance (Evidence level C, Traditional).

Is Devdaru safe during pregnancy and breastfeeding?

Devdaru is contraindicated during pregnancy due to potential uterine stimulant effects and possible teratogenic activity of certain constituents. The essential oil should be strictly avoided during pregnancy and breastfeeding. Animal studies suggest some compounds may affect reproductive parameters. Women who are pregnant, planning pregnancy, or breastfeeding should not use Devdaru in any form. Limited safety data exists for lactation, so avoidance is recommended (Evidence level D).

Can Devdaru treat skin infections and parasites?

Devdaru has been used traditionally in Ayurveda and Unani medicine for skin conditions including fungal infections and parasitic infestations like scabies. The essential oil demonstrates antimicrobial and antifungal activity in laboratory studies, attributed to compounds like himachalol and cedrene. For topical application, the essential oil must be properly diluted to prevent skin irritation. Clinical evidence remains limited (Evidence level C), and persistent skin infections should be evaluated by a healthcare provider.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Cedrus deodara is a medicinal tree from the Pinaceae family used in traditional medicine across Asia for treating skin, joint, and immunological disorders [PMID:34166738].

Contexte

Cedrus deodara (Himalayan cedar) is a medicinal tree traditionally important in the medical systems of India, Pakistan, China, and Korea [PMID:34166738]. It is a keystone species in Western Himalayan forests [PMID:40335897].

Usages traditionnels

Traditionally used in the management of skin diseases, microbial infections, joint disorders, asthma, kidney stones, ulcers, brain disorders, and immunological disorders [PMID:34166738]. In Ayurvedic medicine, the bark is used as a folk medicine to treat infertility in females and remove ovarian cysts [PMID:36690306], and it is used to treat peptic ulcers [PMID:21182918].

Composés actifs

The plant contains phenolic compounds, flavonoids, and tannins [PMID:37064944]. Specific identified compounds include 2R,3R-dihydromyricetin [PMID:25163933], caffeic acid [PMID:38215813], Linalool [PMID:29664038], and bark flavonoids such as deodarin, cedrin, deodardione, and cedrusinin [PMID:36690306]. It also contains sesquiterpenes including atlantolone and alpha-atlantone [PMID:21979930].

Mécanisme d'action

Bark essential oil may induce apoptosis in human colon cancer cells by inhibiting Nuclear Factor kappa B [PMID:32703136]. Total lignans from pine needles may induce apoptosis in A549 cells [PMID:31651320].

Preuves cliniques

Preuve DBurn Wound Healing

A 10% topical ointment of methanol extract of C. deodara wood showed higher wound contraction (up to 93.4% on day 21) in Wistar rats compared to positive controls [PMID:37064944].

Preuve DGastric Ulcers

Volatile oil from the wood showed significant antisecretory activity and reduced the number, score, and index of ulcers in pylorus-ligated and ethanol-treated rats [PMID:21182918].

Preuve DCisplatin-induced Myelosuppression

Methanol extract of C. deodara demonstrated protective effects against bone marrow toxicity in Wistar rats [PMID:35325515].

Preuve DPolycystic Ovarian Syndrome (PCOS)

A chloroform fraction of the bark ameliorated metabolic, endocrine, and ovarian dynamics in rats with testosterone propionate and high-fat diet-induced PCOS [PMID:36690306].

Preuve DObesity/Hyperlipidemia

Ethanolic and acetone extracts reduced body weight, serum glucose, total cholesterol, triglycerides, LDL, and VLDL in MSG-induced obese neonatal rats [PMID:22144766].

Preuve D

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), with some supporting review articles (Level C). There are no human clinical trials or meta-analyses provided.

Sources PubMed

1.PMID: 34166738 (2021) — Cedrus deodara (Roxb. ex D.Don) G.Don: A review of traditional use, phytochemical composition and pharmacology. · Journal of ethnopharmacology
2.PMID: 37064944 (2023) — Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties. · Evidence-based complementary and alternative medicine : eCAM
3.PMID: 28670915 (2018) — Phytochemical and pharmacological properties of essential oils from Cedrus species. · Natural product research
4.PMID: 38215813 (2024) — Phytotoxic phenols from the needles of Cedrus deodara. · Phytochemistry
5.PMID: 29664038 (2017) — Cedrus deodara: In vitro antileishmanial efficacy & immumomodulatory activity. · The Indian journal of medical research

Devdaru

Sources et citations

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