Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
How does Di Fu Zi work for urinary tract problems?
Di Fu Zi (Kochia scoparia) works through its active compounds, primarily saponins and flavonoids, which provide anti-inflammatory and antimicrobial effects. In Traditional Chinese Medicine, it clears damp-heat from the bladder channel, addressing urinary frequency, pain, and infection. The saponins may offer diuretic properties, while flavonoids contribute anti-inflammatory activity. Evidence level C supports these traditional uses, though more rigorous clinical trials are needed to fully confirm the mechanism of action.
Does Di Fu Zi interact with any medications?
Formal drug interaction studies for Di Fu Zi are limited. Due to its diuretic properties, it may potentially interact with prescription diuretics, affecting fluid and electrolyte balance. The herb's antimicrobial activity could theoretically interfere with antibiotic treatments. Patients taking medications for urinary conditions, blood thinners, or those with kidney concerns should consult a healthcare provider before use. Always inform your practitioner about all herbal supplements you are taking.
What is the recommended dosage for Di Fu Zi?
The standard adult dosage for Di Fu Zi is 9-15 grams daily when prepared as a decoction. The herb is traditionally boiled in water and consumed as a tea, typically divided into 2-3 doses throughout the day. Dosage may vary based on the specific condition, individual constitution, and practitioner guidance. Always follow recommendations from a qualified TCM practitioner for personalized dosing appropriate to your health needs.
Is Di Fu Zi safe to take during pregnancy?
Di Fu Zi is contraindicated during pregnancy and should be strictly avoided. Traditional Chinese Medicine classifies this herb as unsafe for pregnant women due to its strong damp-heat clearing properties, which may adversely affect fetal development. The saponin content may stimulate uterine contractions. Women who are pregnant, attempting to conceive, or breastfeeding should not use this herb. Consult a qualified healthcare provider for pregnancy-safe alternatives.
What is Di Fu Zi used to treat?
Di Fu Zi is used in Traditional Chinese Medicine to clear damp-heat from the bladder and relieve itching. Common indications include urinary frequency, urinary pain, skin itching, and as a urinary antiseptic. The herb's anti-pruritic properties make it useful for various dermatological conditions involving itching and inflammation. Evidence level C indicates preliminary support for these traditional applications, though additional clinical research would strengthen the evidence base.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Di Fu Zi (Kochia scoparia) is a medicinal herb used traditionally in Asia for skin, eye, and urinary tract diseases [PMID:33603816]. It has demonstrated anti-inflammatory, anti-cancer, and hypoglycemic potential in experimental models [PMID:33603816, PMID:26707133, PMID:25298688].
Contexte
Kochia scoparia is an annual potherb and fast-spreading weed common in China, Japan, and Korea [PMID:33603816, PMID:27616033]. It is recognized as a halophyte capable of phytoremediation of cadmium and lead contaminated soils [PMID:35138541, PMID:41481076].
Usages traditionnels
Traditionally used for thousands of years in China for the treatment of diseases of the skin, eyes, and urinary tract [PMID:33603816], as well as for breast masses and chest and flank pain [PMID:25298688].
Composés actifs
The fruit contains triterpenoids (specifically oleanane-type triterpene saponins such as momordin Ic), flavonoids, carbohydrates, amino acids, organic acids, and essential oils [PMID:33603816, PMID:37436646]. The essential oil primarily consists of eugenol (75.6%), β-caryophyllene (8.2%), and α-humulene (1.4%) [PMID:37996575].
Mécanisme d'action
Momordin Ic modulates the Wnt/β-catenin pathway by affecting β-catenin nuclear distribution to inhibit cell proliferation and enhance apoptosis [PMID:34326883]. Methanol extracts of the fruit decrease levels of tumor necrosis factor-α, interferon-γ, and monocyte chemotactic protein-1 in inflamed tissues [PMID:26707133].
Preuves cliniques
Preuve DContact Dermatitis
Topical application of methanol and water extracts inhibited ear thickness, weight increase, epidermal acanthosis, and spongiosis in mice [PMID:26707133, PMID:24751363]
Preuve DBreast Cancer
Methanol extract decreased proliferation rates of MDA-MB-231 cells (IC50 36.2 μg/ml) and induced apoptosis [PMID:25298688]
Preuve DOral Squamous Cell Carcinoma
Methanol extract induced apoptosis in vitro and in heterotopic tumors via activation of caspases and MAP kinase p38 [PMID:27616033]
Preuve DMurine Asthma
Ethanolic extract attenuated OVA-induced leukocyte influx into lungs and reduced serum levels of total and OVA-specific IgE [PMID:22122306]
Preuve DObesity/Hyperlipidemia
Ethanol extract and total saponins prevented increases in body weight and plasma triacylglycerol levels in high-fat diet mice [PMID:16892459]
Preuve CPeptic Ulcer
Sécurité et effets indésirables
In veterinary studies, cattle grazing only kochia exhibited toxicosis signs including depression, dehydration, and weight loss, with mortality rates up to 10% [PMID:2711605]. Chronic toxicosis in cattle was associated with high serum bilirubin, glutamic oxaloacetic transaminase, and sorbitol dehydrogenase, and evidence of a thiamin-destructive principle [PMID:6629984]. In humans, one report cited an LD50 of 7.15 mg/kg (though the abstract is truncated) [PMID:33603816].
Synthèse des preuves
The evidence is primarily based on in vitro studies and animal models (Level D), with some supporting review articles (Level C). There is a lack of human clinical trial data in the provided abstracts.
Sources PubMed
1.PMID: 2711605 (1989) — Kochia (Kochia scoparia) toxicosis in cattle: results of four experimental grazing trials. · Veterinary and human toxicology
2.PMID: 28713397 (2017) — Fitness Outcomes Related to Glyphosate Resistance in Kochia (Kochia scoparia): What Life History Stage to Examine? · Frontiers in plant science
3.PMID: 1885401 (1991) — Nutritional and toxicological evaluations of kochia hay (Kochia scoparia) fed to lambs. · Journal of animal science
4.PMID: 26707133 (2016) — Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice. · Molecular medicine reports
5.PMID: 25950428 (2015) — Field-evolved resistance to four modes of action of herbicides in a single kochia (Kochia scoparia L. Schrad.) population. · Pest management science
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
Saponins from Kochia scoparia are identified as botanical compounds with anti-ulcer activity [PMID:11113992]
6.PMID: 37436646 (2023) — New biofunctional effects of oleanane-type triterpene saponins. · Journal of natural medicines
7.PMID: 32647450 (2020) — Improvement of physiological indices and biological yield by intercropping of Kochia (Kochia scoparia), Sesbania (Sesbania aculeata) and Guar (Cyamopsis tetragonoliba) under the salinity stress of irrigation water. · Physiology and molecular biology of plants : an international journal of functional plant biology
8.PMID: 33603816 (2021) — Kochiae Fructus, the Fruit of Common Potherb Kochia scoparia (L.) Schrad: A Review on Phytochemistry, Pharmacology, Toxicology, Quality Control, and Pharmacokinetics. · Evidence-based complementary and alternative medicine : eCAM
9.PMID: 25298688 (2014) — Anti-cancer effects of Kochia scoparia fruit in human breast cancer cells. · Pharmacognosy magazine
10.PMID: 32237544 (2020) — [Effects of Kochia scoparia-Brassica rapa rotation on Cd uptake by Brassica rapa]. · Sheng wu gong cheng xue bao = Chinese journal of biotechnology
11.PMID: 28554695 (2017) — Glyphosate resistance reduces kochia fitness: Comparison of segregating resistant and susceptible F2 populations. · Plant science : an international journal of experimental plant biology
12.PMID: 11113992 (2000) — The plant kingdom as a source of anti-ulcer remedies. · Phytotherapy research : PTR
13.PMID: 27766747 (2018) — Reduced absorption of glyphosate and decreased translocation of dicamba contribute to poor control of kochia (Kochia scoparia) at high temperature. · Pest management science
14.PMID: 27616033 (2016) — Kochia scoparia induces apoptosis of oral cancer cells in vitro and in heterotopic tumors. · Journal of ethnopharmacology
15.PMID: 40946661 (2025) — Integrating Chinese herbal medicine in advanced lung cancer: A multicenter real-world study using target trial emulation. · Phytomedicine : international journal of phytotherapy and phytopharmacology
16.PMID: 37996575 (2023) — The essential oil of Kochia scoparia (L.) Schrad. as a potential repellent against stored-product insects. · Environmental science and pollution research international
17.PMID: 6629984 (1983) — Kochia scoparia poisoning in cattle. · Journal of the American Veterinary Medical Association
18.PMID: 41481076 (2026) — Root biochemical, uptake, and transport behaviors of kochia (Kochia scoparia L.) to cadmium and lead contaminated soil. · International journal of phytoremediation
19.PMID: 1938652 (1991) — Effects of metoclopramide on steers fed Kochia scoparia hay. · Journal of animal science
20.PMID: 29040588 (2018) — Glyphosate Resistance and EPSPS Gene Duplication: Convergent Evolution in Multiple Plant Species. · The Journal of heredity
21.PMID: 35138541 (2022) — Kochia scoparia L., a newfound candidate halophyte, for phytoremediation of cadmium-contaminated saline soils. · Environmental science and pollution research international
22.PMID: 1885403 (1991) — Serum constituents and metabolic hormones in sheep and cattle fed Kochia scoparia hay. · Journal of animal science
23.PMID: 16892459 (2006) — Reduction of fat storage in mice fed a high-fat diet long term by treatment with saponins prepared from Kochia scoparia fruit. · Phytotherapy research : PTR
24.PMID: 22122306 (2011) — Kochia scoparia fruit attenuates allergic airway inflammation in ovalbumin (OVA)-induced murine asthma model. · Inhalation toxicology
25.PMID: 34326883 (2021) — Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway. · Evidence-based complementary and alternative medicine : eCAM
26.PMID: 16667465 (1990) — Mechanism of Sulfonylurea Herbicide Resistance in the Broadleaf Weed, Kochia scoparia. · Plant physiology
27.PMID: 26580558 (2015) — Growth and Reproduction of Glyphosate-Resistant and Susceptible Populations of Kochia scoparia. · PloS one
28.PMID: 41304689 (2025) — The Ionic and Metabolic Response Mechanisms of Kochia scoparia in Response to Saline-Alkaline Stress. · Plants (Basel, Switzerland)
29.PMID: 24751363 (2014) — Topical application of Kochia scoparia inhibits the development of contact dermatitis in mice. · Journal of ethnopharmacology
30.PMID: 31518388 (2019) — The Draft Genome of Kochia scoparia and the Mechanism of Glyphosate Resistance via Transposon-Mediated EPSPS Tandem Gene Duplication. · Genome biology and evolution
Di Fu Zi (Kochia scoparia): Benefits, Dosage, Safety & Evidence | HerbAlly