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PubMed · Polyphenols from <i>Dichrostachys cinerea</i> Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model. (2022)
PubMed · Clinical evaluation of Veerataru (Dichrostachys cinerea Linn.) in the management of Mootrakruchchhra (Dysuria). (2013)
Révisé par : HerbAlly Editorial Team, Medical herbalists and healthcare professionals
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Dichrostachys cinerea is a tropical leguminous shrub used in traditional medicine for inflammatory, respiratory, and urinary conditions [PMID:36080212, 21414220, 24501517].
Contexte
Dichrostachys cinerea (L.) Wigth & Arn. is a tropical leguminous shrub [PMID:28612173] that is widely used in ethno-medicine across Africa [PMID:21414220].
Usages traditionnels
Traditionally used to treat rheumatoid arthritis [PMID:36080212], bronchial asthma [PMID:25914041, 21414220], rheumatism [PMID:25914041, 21731394], dysuria (Mootrakruchchhra) [PMID:24501517], jaundice, fever, body ache, chest problems, toothache, ulcers, wounds, eye diseases, and as an aphrodisiac [PMID:21731394]. It is also used as a laxative, diuretic, and painkiller, and in the treatment of gonorrhoea, boils, oedema, gout, and veneral diseases [PMID:24991072]. In Tanzania, it is used by the Maasai for suspected malaria [PMID:30947717] and as a snakebite antivenom [PMID:36205572].
Composés actifs
The plant contains polyphenols, including flavan-3-ols (such as (-)-mesquitol, oritin, (-)-festidinol, and (-)-epicatechin), proanthocyanidins, and flavone glycosides [PMID:36080212, 21706215]. Other identified compounds include meroterpene derivatives (dichrostachines A-R) [PMID:19761234], betulinic acid, glyceryl-1-hexacosanoate, 7-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, 6-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one [PMID:31360 la], and beta-amyrin glucoside [PMID:24991072]. General phytochemical screening has shown the presence of carbohydrates, proteins, glycosides, saponins, tannins, amino acids, and terpenoids [PMID:24991072].
Mécanisme d'action
Extracts have demonstrated the ability to inhibit protein farnesyl transferase activity [PMID:19761234] and advanced glycation end-product (AGE) formation [PMID:21706215]. Root bark extracts induce relaxation of tracheal smooth muscle [PMID:21963567].
Preuves cliniques
Preuve DInflammation and Pain (Rat Model)
Polyphenol-rich fruit extracts showed analgesic, anti-inflammatory, and antioxidant effects in Freund's adjuvant-induced arthritic rats [PMID:36080212]
Preuve BDysuria
Evaluated for efficacy in the management of Mootrakruchchhra (Dysuria) [PMID:24501517]
Leaf extracts showed antibacterial activity against S. epidermidis and S. aureus [PMID:38045177, 10844173]
Preuve DCancer (In vitro)
Triterpenoid 1 (betulinic acid) and flavone 4 from bark showed cytotoxic effects against 9 cancer cell lines [PMID:31360210]
Preuve DAsthma (Animal Model)
Methanolic and aqueous-alcoholic extracts induced relaxation of guinea-pig and mouse tracheal smooth muscle [PMID:21414220, 21963567]
Sécurité et effets indésirables
A methanolic extract of leaves did not show mortality in albino mice and rats up to a dose of 3500 mg/kg body weight [PMID:21731394].
Grossesse et allaitement
Bark extracts are traditionally used to facilitate childbirth; in vitro studies on isolated pregnant rat myometrium were conducted to investigate these properties [PMID:25914041].
Synthèse des preuves
The evidence consists primarily of in vitro studies, animal models (rats, mice, guinea-pigs), and preliminary clinical evaluations. There is a lack of high-level human clinical trials (Meta-analyses or large-scale RCTs).
Sources PubMed
1.PMID: 36080212 (2022) — Polyphenols from Dichrostachys cinerea Fruits Anti-Inflammatory, Analgesic, and Antioxidant Capacity in Freund's Adjuvant-Induced Arthritic Rat Model. · Molecules (Basel, Switzerland)
3.PMID: 24501517 (2013) — Clinical evaluation of Veerataru (Dichrostachys cinerea Linn.) in the management of Mootrakruchchhra (Dysuria). · Ayu
4.PMID: 25914041 (2015) — Study of pharmacological properties of the methanolic extract of Dichrostachys cinerea bark (L.) Wight et Arn (Leguminosae) in isolated myometrium from pregnant rats. · Journal of ethnopharmacology
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
— In vitro and in vivo studies on anti-malarial activity of Commiphora africana and Dichrostachys cinerea used by the Maasai in Arusha region, Tanzania.
· Malaria journal
6.PMID: 21414220 (2011) — Dichrostachys cinerea (L.) Wight et Arn (Mimosaceae) hydro-alcoholic extract action on the contractility of tracheal smooth muscle isolated from guinea-pig. · BMC complementary and alternative medicine
7.PMID: 21963567 (2011) — Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K⁺ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark. · Journal of ethnopharmacology
8.PMID: 28612173 (2017) — Evaluation of the feeding value of Dichrostachys cinerea pods for fattening pigs in Cuba. · Tropical animal health and production
9.PMID: 21731394 (2011) — Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves. · Pharmacognosy research
10.PMID: 24991072 (2013) — Phytochemical analysis of ethanolic extract of Dichrostachys Cinerea W and Arn leaves by a thin layer chromatography, high performance thin layer chromatography and column chromatography. · Ancient science of life
11.PMID: 38045177 (2023) — Antibacterial and phytochemical analysis of traditional medicinal plants: An alternative therapeutic Approach to conventional antibiotics. · Heliyon
12.PMID: 19761234 (2009) — Meroterpenes from Dichrostachys cinerea inhibit protein farnesyl transferase activity. · Journal of natural products
13.PMID: 36205572 (2022) — Ethnomedicinal plants used for treatment of snakebites in Tanzania - a systematic review. · Pharmaceutical biology
14.PMID: 31360210 (2019) — Cytotoxicity of Crude Extract and Isolated Constituents of the Dichrostachys cinerea Bark towards Multifactorial Drug-Resistant Cancer Cells. · Evidence-based complementary and alternative medicine : eCAM
15.PMID: 29859076 (2018) — Antibacterial activity and in situ efficacy of Bidens pilosa Linn and Dichrostachys cinerea Wight et Arn extracts against common diarrhoea-causing waterborne bacteria. · BMC complementary and alternative medicine
16.PMID: 21706215 (2012) — New advanced glycation end-products inhibitors from Dichrostachys cinerea Wight & Arn. · Journal of natural medicines
17.PMID: 28684709 (2017) — Trypanosoma brucei Inhibition by Essential Oils from Medicinal and Aromatic Plants Traditionally Used in Cameroon (Azadirachta indica, Aframomum melegueta, Aframomum daniellii, Clausena anisata, Dichrostachys cinerea and Echinops giganteus). · International journal of environmental research and public health