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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Brassica oleracea extract
Extrait d'une légume crucifère pour équilibrer le métabolisme des hormones.
DIM Natural is a supplement derived from indole-3-carbinol found in cruciferous vegetables like broccoli (Brassica oleracea). It is primarily used to support healthy estrogen metabolism by promoting the 2-hydroxylation pathway over the 4- and 16α-hydroxylation pathways, thereby reducing estrogenic metabolites associated with hormone imbalance. Key active compounds include diindolylmethane (DIM), indole-3-carbinol, and sulforaphane, which also support phase I and II liver detoxification.
DIM modulates estrogen metabolism by inducing cytochrome P450 enzymes CYP1A1 and CYP1A2, which preferentially hydroxylate estradiol at the C-2 position, producing 2-hydroxyestrone (2-OHE1), a weak estrogen with antiproliferative properties. It also inhibits the 4- and 16α-hydroxylation pathways, reducing genotoxic metabolites like 4-hydroxyestrone and 16α-hydroxyestrone. Additionally, DIM activates the Nrf2/ARE pathway, upregulating phase II detoxification enzymes such as glutathione S-transferase and UDP-glucuronosyltransferase, and exhibits anti-androgenic effects by inhibiting 5α-reductase and androgen receptor signaling.
Extrait d'une légume crucifère pour équilibrer le métabolisme des hormones.
DIM Natural is a supplement derived from indole-3-carbinol found in cruciferous vegetables like broccoli (Brassica oleracea). It is primarily used to support healthy estrogen metabolism by promoting the 2-hydroxylation pathway over the 4- and 16α-hydroxylation pathways, thereby reducing estrogenic metabolites associated with hormone imbalance. Key active compounds include diindolylmethane (DIM), indole-3-carbinol, and sulforaphane, which also support phase I and II liver detoxification.
DIM modulates estrogen metabolism by inducing cytochrome P450 enzymes CYP1A1 and CYP1A2, which preferentially hydroxylate estradiol at the C-2 position, producing 2-hydroxyestrone (2-OHE1), a weak estrogen with antiproliferative properties. It also inhibits the 4- and 16α-hydroxylation pathways, reducing genotoxic metabolites like 4-hydroxyestrone and 16α-hydroxyestrone. Additionally, DIM activates the Nrf2/ARE pathway, upregulating phase II detoxification enzymes such as glutathione S-transferase and UDP-glucuronosyltransferase, and exhibits anti-androgenic effects by inhibiting 5α-reductase and androgen receptor signaling.