Dipsacus Root (Dipsacus asper): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Dipsacus root work for bone healing?

Dipsacus root contains active compounds including asperosaponin and dipsacoside that support bone metabolism and tissue repair. In TCM theory, it tonifies the liver and kidneys, which govern the sinews and bones respectively. Laboratory studies suggest these saponins may promote osteoblast activity and reduce inflammation at injury sites. Evidence Level: C. The herb's traditional use for fractures spans centuries, though more rigorous clinical trials are needed to fully elucidate its mechanisms.

Does Dipsacus root interact with any medications?

There are no well-documented drug interactions for Dipsacus root in current literature. However, due to limited research, caution is advised when combining with anticoagulant medications, as some saponin-containing herbs may affect blood clotting. Patients taking prescription medications should consult a qualified healthcare practitioner before adding Dipsacus root to their regimen. Evidence Level: C. Always disclose all supplements to your healthcare provider.

What is the recommended dosage for Dipsacus root?

The typical adult dosage for Dipsacus root is 9-21 grams of dried herb per day, usually prepared as a decoction or taken in pill form. Dosage may vary based on the specific condition being treated and individual constitution. In TCM practice, it is often combined with other herbs in formula prescriptions. Evidence Level: Traditional. Consult a qualified herbalist or healthcare practitioner for personalized dosing recommendations.

Is Dipsacus root safe during pregnancy?

Dipsacus root has been traditionally used in TCM to prevent threatened miscarriage and is generally considered safe during pregnancy when used appropriately. It tonifies the kidneys and helps secure the fetus according to traditional theory. Evidence Level: C. However, pregnant women should only use this herb under the guidance of a qualified TCM practitioner, as improper use or incorrect diagnosis could pose risks. Self-medication during pregnancy is not recommended.

What is Dipsacus root used for in traditional Chinese medicine?

Dipsacus root is primarily used in TCM to mend bones and sinews, tonify the liver and kidneys, and support trauma healing. It is commonly prescribed for fractures, ligament injuries, lower back pain, and weakness in the knees and legs. Additionally, it is used for threatened miscarriage due to its kidney-tonifying properties. Evidence Level: C. The herb has been used for centuries in East Asian medicine for these purposes, though modern clinical evidence remains limited.

What are the side effects of Dipsacus root?

Dipsacus root is generally well tolerated with few reported side effects. Traditional contraindications include caution in cases of Yin deficiency with heat signs, as the herb's warming properties may exacerbate these conditions. Mild digestive upset may occur in sensitive individuals. Evidence Level: Traditional. As with any medicinal herb, quality and sourcing matter—purchase from reputable suppliers to ensure product safety and purity.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Dipsacus asper is a traditional medicinal herb used primarily for bone and joint disorders [PMID:37175164, PMID:32348843]. It contains a diverse array of specialized metabolites, including triterpenoid saponins and iridoids, which exhibit various biological activities [PMID:37175164, PMID:32348843].

Contexte

Dipsacus asper Wall. ex C.B. Clarke is a perennial herb of the Caprifoliaceae family [PMID:37175164, PMID:37591362]. The dried roots, known as Dipsaci radix or Xuduan, are included in the Chinese and Korean Herbal Pharmacopoeias [PMID:37175164, PMID:32348843].

Usages traditionnels

It has been used for centuries in Chinese and Korean folk medicines to treat bone diseases such as osteoporosis and bone fractures, joint problems like rheumatic arthritis, traumatic hematoma, uterine bleeding, and conditions caused by liver and kidney deficiency [PMID:37175164, PMID:32348843, PMID:36164864].

Composés actifs

The root contains over 100 isolated compounds [PMID:32348843], including triterpenoid saponins (e.g., Akebia saponin D, Asperosaponin VI, dipsacus saponin C, cauloside A) [PMID:41547071, PMID:41093224, PMID:22405282, PMID:28911735], iridoid glycosides (e.g., loganin, cantleyoside, dipsanosides A-G) [PMID:36607173, PMID:18057739, PMID:16671811], phenolic acids (e.g., caffeic acid, vanillic acid) [PMID:18057739], sterols (e.g., beta-sitosterol, campesterol, stigmasterol) [PMID:28911735, PMID:23627090], and polysaccharides [PMID:30735778].

Mécanisme d'action

Mechanisms vary by compound: Akebia saponin D activates the IGF1R/AMPK signaling pathway to ameliorate skeletal muscle insulin resistance [PMID:37591362] and activates AMPK to attenuate allergic airway inflammation [PMID:38175326]. Asperosaponin VI suppresses nucleus pulposus cell pyroptosis via modulation of the NF-κB/NLRPP3 pathway [PMID:41093224]. Dipsacus asper polysaccharides regulate the RANKL/RANK/OPG/VEGF and PI3K/Akt/eNOS pathways to prevent bone loss [PMID:30735778]. Dipsacus asper extract may induce osteogenesis via the PI3K pathway [PMID:34301001].

Preuves cliniques

Preuve DOsteoporosis

Dipsacus asper polysaccharide significantly prevented bone loss and biomechanical reduction in ovariectomized rat models [PMID:30735778].

Preuve DOsteoarthritis

A herb pair of Dipsacus asper and Achyranthes bidentate reduced levels of TNF-α, IL-1β, IL-6, and iNOS in osteoarthritic rats [PMID:38723559].

Preuve DCognitive Impairment (Aluminum-induced)

Dipsacus asper extract reduced cognitive deficits and the overexpression of beta-amyloid protein in rats exposed to aluminum [PMID:12954453].

Preuve DSepsis-associated encephalopathy

Dipsacoside B effectively alleviated cognitive impairment and suppressed central inflammatory responses in SAE mice [PMID:39009096].

Preuve DUlcerative Colitis

Akebia saponin D attenuated ulcerative colitis in a DSS-induced mouse model [PMID:41547071].

Sécurité et effets indésirables

Dipsacus saponin C was identified as a key ingredient that potently induces procoagulant activities in human platelets, potentially increasing pro-thrombotic risks [PMID:22405282].

Synthèse des preuves

The current evidence is primarily based on in vitro studies and animal models (Level D), with a few review articles (Level C) summarizing traditional uses and phytochemistry. No human clinical trials (Level B) or meta-analyses (Level A) were provided.

Sources PubMed

1.PMID: 37175164 (2023) — Dipsacus and Scabiosa Species-The Source of Specialized Metabolites with High Biological Relevance: A Review. · Molecules (Basel, Switzerland)
2.PMID: 32348843 (2020) — Traditional uses, processing methods, phytochemistry, pharmacology and quality control of Dipsacus asper Wall. ex C.B. Clarke: A review. · Journal of ethnopharmacology
3.PMID: 36607173 (2023) — Divergent Total Syntheses of Hetero-Oligomeric Iridoid Glycosides. · Organic letters
4.PMID: 41547071 (2026) — Akebia saponin D attenuates ulcerative colitis via targeting EGFR and remodeling gut microbiota homeostasis. · Phytomedicine : international journal of phytotherapy and phytopharmacology
5.PMID: 42144814 (2026) — Two Unpresented Triterpenoid Saponins From Dipsacus asper.

Dipsacus Root

Sources et citations

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