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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Coscinium fenestratum
Liane très prisée en Thaïlande et en Ayurveda, riche en berbérine, utilisée pour le foie, le diabète et les infections.
Coscinium fenestratum (Doku Chini) is a climbing vine native to Southeast Asia and India, highly valued in Thai and Ayurvedic medicine. Its primary active compound, berberine, along with other alkaloids such as palmatine and jatrorrhizine, contributes to its broad spectrum of pharmacological activities including antimicrobial, hypoglycemic, hepatoprotective, and anti-inflammatory effects. The herb is traditionally used for liver disorders, diabetes, infections, and digestive complaints, though clinical evidence remains limited (Level C).
Berberine, the major alkaloid, exerts its effects through multiple mechanisms: it activates AMP-activated protein kinase (AMPK), improving insulin sensitivity and glucose uptake; inhibits bacterial DNA gyrase and topoisomerase IV, conferring broad-spectrum antimicrobial activity; and suppresses NF-κB signaling, reducing pro-inflammatory cytokines. Additionally, berberine upregulates LDL receptor expression via ERK pathway, lowering cholesterol, and induces heme oxygenase-1 (HO-1) to protect hepatocytes. Palmatine and jatrorrhizine contribute to anti-inflammatory and hepatoprotective actions by modulating CYP450 enzymes and antioxidant pathways.
Liane très prisée en Thaïlande et en Ayurveda, riche en berbérine, utilisée pour le foie, le diabète et les infections.
Coscinium fenestratum (Doku Chini) is a climbing vine native to Southeast Asia and India, highly valued in Thai and Ayurvedic medicine. Its primary active compound, berberine, along with other alkaloids such as palmatine and jatrorrhizine, contributes to its broad spectrum of pharmacological activities including antimicrobial, hypoglycemic, hepatoprotective, and anti-inflammatory effects. The herb is traditionally used for liver disorders, diabetes, infections, and digestive complaints, though clinical evidence remains limited (Level C).
Berberine, the major alkaloid, exerts its effects through multiple mechanisms: it activates AMP-activated protein kinase (AMPK), improving insulin sensitivity and glucose uptake; inhibits bacterial DNA gyrase and topoisomerase IV, conferring broad-spectrum antimicrobial activity; and suppresses NF-κB signaling, reducing pro-inflammatory cytokines. Additionally, berberine upregulates LDL receptor expression via ERK pathway, lowering cholesterol, and induces heme oxygenase-1 (HO-1) to protect hepatocytes. Palmatine and jatrorrhizine contribute to anti-inflammatory and hepatoprotective actions by modulating CYP450 enzymes and antioxidant pathways.