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ST
Not CommonVérifié
Ssanghwa Tang Herbs
Eucommia ulmoides
Douleurs lombaires et aux genoux dues à un déficit du rein en MTC et Hanbang
How does Eucommia ulmoides work to lower blood pressure?
Eucommia ulmoides lowers blood pressure primarily through vasodilation. Its active compounds, specifically pinoresinol diglucoside and geniposidic acid, act as calcium channel blockers and promote the release of nitric oxide, which relaxes blood vessels. It also modulates the renin-angiotensin system. These actions help improve endothelial function and reduce vascular resistance, contributing to its antihypertensive effects. Evidence level: C.
Can I take Eucommia ulmoides with blood pressure medication?
You should use caution when taking Eucommia ulmoides with antihypertensive drugs. Because the herb has natural blood pressure-lowering properties, combining it with prescription medications like ACE inhibitors or beta-blockers may cause additive effects, leading to hypotension (abnormally low blood pressure). Symptoms may include dizziness or fainting. It is essential to monitor blood pressure closely and consult a healthcare provider before combining these treatments. Evidence level: C.
What is the recommended dosage for Eucommia ulmoides bark?
The standard adult dosage for Eucommia ulmoides bark depends on the form. For a decoction (tea), the traditional dose is 9–15 grams of dried bark daily. For standardized extracts, a common dosage is 500 mg taken twice daily. Because potency varies between manufacturers, always follow specific product labels. It is best taken with warm water to support absorption and reduce potential gastric upset. Evidence level: Traditional.
Is Eucommia ulmoides safe during pregnancy?
Eucommia ulmoides is generally considered unsafe during pregnancy, particularly in large medicinal doses. While it is a kidney tonic often used for lower back pain, traditional texts and modern safety standards advise against its use by pregnant women due to insufficient safety data and potential uterine effects. Therapeutic supplementation should be avoided unless specifically prescribed by a qualified practitioner. Evidence level: D.
Does Eucommia bark really help with lower back pain?
Yes, Eucommia ulmoides is traditionally used to strengthen the lower back and knees. In Traditional Chinese Medicine, it is classified as a kidney yang tonic, addressing 'kidney deficiency' which manifests as chronic lower back weakness and pain. Modern research suggests it may support connective tissue and bone health, potentially aiding recovery. While clinical evidence is limited, it remains a primary herb for lumbar support in Asian medicine. Evidence level: C.
Can Eucommia ulmoides help treat osteoporosis?
Eucommia ulmoides shows promise for bone health and osteoporosis prevention. Preclinical studies indicate that compounds like aucubin may stimulate osteoblast activity and inhibit bone resorption. In Korean and Chinese traditional medicine, it is used to strengthen the skeleton, as kidneys are believed to rule the bones. While animal data is positive, human clinical trials are currently insufficient to confirm efficacy as a standalone treatment. Evidence level: C.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Eucommia ulmoides is a traditional medicinal herb used in China, Japan, and Korea with diverse pharmaceutical properties, including effects on bone health and metabolic disorders [PMID:35744822, PMID:29745662].
Contexte
Eucommia ulmoides Oliver (also known as Du Zhong) is a tree species native to China [PMID:39221141, PMID:30857406]. The medicinal parts of the plant include the bark (Eucommiae cortex) and leaves (Eucommiae folium) [PMID:39221141].
Usages traditionnels
Traditionally used in Chinese medicine to treat lumbar pain, knee pain, osteoporosis, hepatoprotection, paralysis, intestinal haemorrhoids, vaginal bleeding, abortion, spermatorrhoea, and foot fungus [PMID:34362420]. It is also used for tonifying the liver and kidney, strengthening muscles and bones, and miscarriage prevention [PMID:38972653, PMID:29745662].
Composés actifs
Bioactive constituents include lignans (such as pinoresinol diglucoside), iridoids (such as aucubin and geniposide), phenolics, steroids, terpenoids, flavonoids, and polysaccharides [PMID:29745662, PMID:38442791, PMID:40630123, PMID:39221141]. It also contains trans-1,4-polyisoprene (Eucommia ulmoides rubber) [PMID:33761246].
Mécanisme d'action
Mechanisms include enhancing intestinal mucosal barrier function and antioxidant capacity [PMID:37438752], regulating the YAP/β-catenin/VEGF axis in bone marrow mesenchymal stem cells to promote fracture healing [PMID:39366157], and modulating the F. prausnitzii/butyrate/GPR43/GLP-1 signaling pathway to alleviate liver disease [PMID:40935212]. It may also remodel intestinal microbiota to reduce cerebral infarction and neuronal death [PMID:41288788].
Preuves cliniques
Preuve AOsteoporosis
Extracts significantly improved bone mineral density in osteoporotic rat models [PMID:41059187].
Preuve DOsteoporosis (Lead-induced)
Cortex extract (100 mg/kg) alleviated lead acetate-induced bone loss in rats [PMID:29740803].
Preuve DHyperglycemia
Powdered leaves and water extracts significantly lowered blood glucose levels in streptozotocin-induced diabetic rats [PMID:15620430].
Preuve DColitis
Modified nano-selenium polysaccharides (EUP-SeNP) alleviated DSS-induced colitis in mice by restoring weight and reducing disease activity index [PMID:37438752].
Preuve DCerebral Ischemic Stroke
Extract reduced cerebral infarction area, ameliorated neurological deficits, and reduced neuronal death in mice [PMID:41288788].
Preuve DMASLD
Bark extract (EBE) showed protective effects against high-fat diet-induced metabolic dysfunction-associated steatotic liver disease in mice [PMID:40935212].
Sécurité et effets indésirables
Eucommia ulmoides extract (EUE) is non-genotoxic within tested dose ranges; however, long-term administration (13 weeks) led to dose-dependent increases in nephrotoxicity-related indices and pathological changes in renal tissues, which persisted at high dosages (56 g/kg) [PMID:33122045].
Synthèse des preuves
The evidence is primarily based on animal models (rats, mice, zebrafish) and in vitro studies, with one systematic review/meta-analysis of rat models. Clinical studies in humans are reported to be scarce [PMID:35744822, PMID:41059187].
Sources PubMed
1.PMID: 37438752 (2023) — Eucommia ulmoides polysaccharide modified nano-selenium effectively alleviated DSS-induced colitis through enhancing intestinal mucosal barrier function and antioxidant capacity. · Journal of nanobiotechnology
2.PMID: 33761246 (2021) — Natural Polymer Eucommia Ulmoides Rubber: A Novel Material. · Journal of agricultural and food chemistry
4.PMID: 38442791 (2024) — Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish. · Toxicology and applied pharmacology
5.PMID: 39366157 (2024) — Single-cell RNA transcriptomics reveals Du-Zhong-Wan promotes osteoporotic fracture healing via YAP/β-catenin/VEGF axis in BMSCs.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
· Phytomedicine : international journal of phytotherapy and phytopharmacology
6.PMID: 33122045 (2020) — Safety evaluation of Eucommia ulmoides extract. · Regulatory toxicology and pharmacology : RTP
7.PMID: 29745662 (2018) — Eucommia ulmoides Oliver: A Potential Feedstock for Bioactive Products. · Journal of agricultural and food chemistry
8.PMID: 40935212 (2026) — Eucommia alleviates high fat diet-induced MASLD via the F. prausnitzii/butyrate/GPR43/GLP-1 signaling. · Journal of ethnopharmacology
9.PMID: 40630123 (2025) — Eucommia ulmoides Oliv. and its bioactive compounds: therapeutic potential in bone diseases. · Frontiers in pharmacology
10.PMID: 35753260 (2022) — Chemical profiling, quantitation, and bioactivities of Du-Zhong tea. · Food chemistry
11.PMID: 39221141 (2024) — Advances in Eucommia ulmoides polysaccharides: extraction, purification, structure, bioactivities and applications. · Frontiers in pharmacology
12.PMID: 38732399 (2024) — Genome-Wide Identification and Expression Analysis of Growth-Regulating Factors in Eucommia ulmoides Oliver (Du-Zhong). · Plants (Basel, Switzerland)
13.PMID: 27042191 (2016) — Health-Promoting Properties of Eucommia ulmoides: A Review. · Evidence-based complementary and alternative medicine : eCAM
14.PMID: 24296089 (2014) — Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. · Journal of ethnopharmacology
15.PMID: 41059187 (2025) — Therapeutic effects of Eucommia ulmoides extract on osteoporosis rat models: a systematic review and meta-analysis. · Frontiers in pharmacology
16.PMID: 36904423 (2023) — Intelligent Eucommia ulmoides Rubber/Ionomer Blends with Thermally Activated Shape Memory and Self-Healing Properties. · Polymers
17.PMID: 30857406 (2019) — Ethnobotany, Phytochemistry and Pharmacological Properties of Eucommia ulmoides: A Review. · The American journal of Chinese medicine
18.PMID: 29740803 (2019) — Du-Zhong (Eucommia ulmoides Oliv.) Cortex Extract Alleviates Lead Acetate-Induced Bone Loss in Rats. · Biological trace element research
19.PMID: 37071384 (2023) — Extraction of Eucommia ulmoides gum and microbial lipid from Eucommia ulmoides Oliver leaves by dilute acid hydrolysis. · Biotechnology letters
20.PMID: 34362420 (2021) — Traditional application and modern pharmacological research of Eucommia ulmoides Oliv. · Chinese medicine
21.PMID: 15620430 (2005) — Hypoglycemic effect of Du-zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats. · Diabetes research and clinical practice
22.PMID: 37110564 (2023) — Quantitative Detection of Natural Rubber Content in Eucommia ulmoides by Portable Pyrolysis-Membrane Inlet Mass Spectrometry. · Molecules (Basel, Switzerland)
23.PMID: 38972653 (2024) — Preparation techniques, structural features, and bioactivities of Eucommia ulmoides polysaccharides: A review. · International journal of biological macromolecules
24.PMID: 38754661 (2024) — Histochemical studies on the distribution and accumulation of trans-polyisoprene in the rubber-producing plant Eucommia ulmoides. · International journal of biological macromolecules
25.PMID: 38902931 (2024) — Research Progress of Eucommia ulmoides Oliv and Predictive Analysis of Quality Markers Based on Network Pharmacology. · Current pharmaceutical biotechnology
26.PMID: 32767065 (2020) — Structure and Function of Bacterial Microbiota in Eucommia ulmoides Bark. · Current microbiology
27.PMID: 31226307 (2019) — PCL/EUG scaffolds with tunable stiffness can regulate macrophage secretion behavior. · Progress in biophysics and molecular biology
28.PMID: 34913224 (2022) — Metabolism of Du Zhong Formula in rats using UPLC-Q-TOF/MS. · Journal of mass spectrometry : JMS
29.PMID: 27173246 (2016) — Isolation and characterization of microsatellite markers for Eucommia ulmoides (Eucommiaceae), an endangered tree, using next-generation sequencing. · Genetics and molecular research : GMR
30.PMID: 41288788 (2025) — Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites. · Metabolic brain disease