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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Sambucus ebulus
Pérénnial court provenant de terres abandonnées européennes ; toutes les parties sont plus toxiques que la genisse commune ; historiquement utilisé comme purgatif puissant et émétique.
Dwarf elder (Sambucus ebulus) is a toxic perennial herb historically employed as a drastic purgative and emetic in European folk medicine, with all plant parts containing cyanogenic glycosides and saponins. Modern research focuses on its toxic alkaloids and limited anti-inflammatory potential, but clinical evidence is lacking due to safety concerns. Key compounds include sambunigrin, saponins, and cyanogenic glycosides that contribute to its severe gastrointestinal and systemic toxicity.
Cyanogenic glycosides (e.g., sambunigrin) release hydrogen cyanide upon hydrolysis, inhibiting cytochrome c oxidase in the mitochondrial electron transport chain, leading to cellular hypoxia and metabolic acidosis. Saponins and alkaloids irritate gastrointestinal mucosa, stimulating emetic and purgative reflexes via vagal afferents and local prostaglandin release. The herb's anti-inflammatory activity in traditional poultices may involve inhibition of cyclooxygenase and lipoxygenase pathways, though this is not validated clinically.
Pérénnial court provenant de terres abandonnées européennes ; toutes les parties sont plus toxiques que la genisse commune ; historiquement utilisé comme purgatif puissant et émétique.
Dwarf elder (Sambucus ebulus) is a toxic perennial herb historically employed as a drastic purgative and emetic in European folk medicine, with all plant parts containing cyanogenic glycosides and saponins. Modern research focuses on its toxic alkaloids and limited anti-inflammatory potential, but clinical evidence is lacking due to safety concerns. Key compounds include sambunigrin, saponins, and cyanogenic glycosides that contribute to its severe gastrointestinal and systemic toxicity.
Cyanogenic glycosides (e.g., sambunigrin) release hydrogen cyanide upon hydrolysis, inhibiting cytochrome c oxidase in the mitochondrial electron transport chain, leading to cellular hypoxia and metabolic acidosis. Saponins and alkaloids irritate gastrointestinal mucosa, stimulating emetic and purgative reflexes via vagal afferents and local prostaglandin release. The herb's anti-inflammatory activity in traditional poultices may involve inhibition of cyclooxygenase and lipoxygenase pathways, though this is not validated clinically.