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ER
Not CommonVérifié
Elecampane Root
Inula helenium
Bronchite chronique et catarrhe respiratoire en Europe
Elecampane root contains sesquiterpene lactones, specifically alantolactone and isoalantolactone, which provide its primary medicinal actions. These compounds stimulate the respiratory mucosa, increasing mucus secretion and facilitating expectoration. The high inulin content also provides demulcent properties that soothe irritated tissues. Alantolactone and isoalantolactone were among the first sesquiterpene lactones demonstrated to have antibiotic activity against respiratory pathogens. Evidence level: B.
Does elecampane interact with any medications?
There are no well-documented drug interactions for elecampane root in the scientific literature. However, due to its potential effects on gastrointestinal motility and mild antibiotic properties, it may theoretically affect the absorption of some medications. Those taking immunosuppressants or medications metabolised by the liver should consult a healthcare provider before use. Always inform your prescriber about all herbal supplements you are taking. Evidence level: Traditional/insufficient data.
What is the recommended dosage for elecampane root?
The standard adult dosage for elecampane root is 1-2 grams of dried root powder taken three times daily, or 4ml of tincture (1:5 strength) three times daily. For chronic respiratory conditions, this dosage is typically taken for 2-4 weeks. The root should be prepared as a decoction by simmering in water for 10-15 minutes if using the dried herb. Always start with the lower dose to assess tolerance. Evidence level: B.
Is elecampane safe to take during pregnancy?
No, elecampane root is not considered safe during pregnancy. The sesquiterpene lactones, particularly alantolactone, may stimulate uterine contractions and pose a risk of miscarriage. Pregnant women should avoid elecampane in all forms, including teas, tinctures, and capsules. Breastfeeding women should also avoid elecampane due to insufficient safety data and potential transfer of active compounds into breast milk. Evidence level: Traditional contraindication supported by pharmacological rationale.
What is elecampane root used for medicinally?
Elecampane root is primarily used as a respiratory remedy for chronic bronchitis, persistent coughs, and respiratory catarrh. It acts as an expectorant, helping to clear mucus from the lungs and airways. Traditional uses also include treatment of intestinal parasites due to its antiparasitic properties, and certain skin disorders. In European herbal medicine, it has been used for centuries as a warming, stimulating remedy for congested respiratory conditions. Evidence level: B.
What are the side effects of elecampane root?
Common side effects of elecampane include mild gastrointestinal discomfort such as nausea, stomach upset, or diarrhoea, particularly when taken on an empty stomach. Contact dermatitis can occur in sensitive individuals due to the sesquiterpene lactones, especially in those with known allergies to plants in the Asteraceae family, such as ragweed, chamomile, or marigolds. Discontinue use if skin rash or allergic symptoms develop. Evidence level: B.
Fiche d'information compilée à partir de PubMed
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Inula helenium (Elecampane) root is a medicinal plant containing sesquiterpene lactones with demonstrated antimicrobial, anti-inflammatory, and antioxidant properties [PMID:35209195, 39376605, 33825410].
Contexte
Inula helenium L., commonly known as elecampane, is a plant of the Asteraceae (Compositae) family [PMID:35209195, 17919303]. Its roots and rhizomes are used to extract biologically active substances, including sesquiterpenes and phenolic compounds [PMID:34134031, 30428203].
Usages traditionnels
Historically, it has been used for respiratory and dermal ailments [PMID:35209195], chronic sore boils, skin eruptions, and itch [PMID:12587579]. It is also cited in ancient pharmacotherapy for treating neoplasms, wounds, freckles, and dandruff [PMID:24754913].
Composés actifs
Major active compounds include sesquiterpene lactones such as alantolactone (ALA), isoalantolactone (ISO), and alloalantolactone [PMID:35897937, 30661396]. Other constituents include eudesmane-type sesquiterpenes [PMID:34134031], inulin [PMID:30428203], and phenolic acids such as chlorogenic, ferulic, rosmarinic, and caffeic acids [PMID:33825410, 35684497].
Mécanisme d'action
Alantolactone suppresses inflammation and oxidative stress by activating Nrf2/HO-1 and inhibiting NF-κB pathways [PMID:32321531]. Isoalantolactone also exerts anti-inflammatory and neuroprotective effects via NF-κB inhibition [PMID:39376605]. Root extracts may inhibit adipogenesis by co-regulating AMPKα and Nur77 [PMID:35897937].
Preuves cliniques
Preuve DInflammation and Oxidative Stress (In vitro)
Alantolactone suppresses inflammation, apoptosis, and oxidative stress in cigarette smoke-induced human bronchial epithelial cells [PMID:32321531]
Preuve DAdipogenesis (In vitro)
Elecampane root extract and alantolactone inhibit the adipogenic differentiation of 3T3-L1 cells [PMID:35897937]
Preuve DPancreatic Cancer (In vitro)
A mixture of alantolactone, isoalantolactone, and alloalantolactone induces mitochondrion-related apoptosis and inhibits proliferation and migration in PANC-1 and SW1990 cells [PMID:30661396]
Preuve DSkin Wound Healing (In vivo/In vitro)
Inula helenium extract loaded in nanofibers showed antioxidative and anti-inflammatory activities and promoted skin wound healing in a rat model [PMID:39042854]
Preuve BGrowth Performance (Veterinary)
Dietary methanol and n-hexane extracts of elecampane rhizome increased body weight gain and decreased feed conversion ratio in broiler chickens during the finisher and entire periods [PMID:30821191]
Sécurité et effets indésirables
Elecampane is recognized as a potential allergen; sensitization and contact dermatitis occur relatively frequently with this species within the Compositae family [PMID:17919303, 12492516]. It is also suspected of causing systemic allergic dermatitis [PMID:27568784].
Interactions médicamenteuses
Some sesquiterpenes from Inula helenium can synergistically enhance the effect of cisplatin against ovarian cancer cells [PMID:34134031].
Synthèse des preuves
The evidence consists primarily of in vitro studies (cell lines) and animal models (rats, broiler chickens) demonstrating pharmacological potential. There is a lack of human clinical trials. Safety data highlights a risk of allergic contact dermatitis.
Sources PubMed
1.PMID: 32321531 (2020) — Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways. · Respiratory research
2.PMID: 35209195 (2022) — From Monographs to Chromatograms: The Antimicrobial Potential of Inula helenium L. (Elecampane) Naturalised in Ireland. · Molecules (Basel, Switzerland)
3.PMID: 35897937 (2022) — Elecampane (Inula helenium) Root Extract and Its Major Sesquiterpene Lactone, Alantolactone, Inhibit Adipogenesis of 3T3-L1 Preadipocytes. · Molecules (Basel, Switzerland)
4.PMID: 39376605 (2024) — Isoalantolactone: a review on its pharmacological effects. · Frontiers in pharmacology
5.PMID: 34134031 (2021) — Bioactive sesquiterpenes from Inula helenium.
Sources gouvernementales
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 17919303 (2008) — Contact allergy and medicinal herbs. · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
7.PMID: 33825410 (2021) — Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage. · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
8.PMID: 12492516 (2002) — Contact sensitization from Compositae-containing herbal remedies and cosmetics. · Contact dermatitis
9.PMID: 30821191 (2019) — Comparative effects of n-hexane and methanol extracts of elecampane (Inula helenium L.) rhizome on growth performance, carcass traits, feed digestibility, intestinal antioxidant status and ileal microbiota in broiler chickens. · Archives of animal nutrition
14.PMID: 35684497 (2022) — Biological Activities and Chemical Profile of Gentiana asclepiadea and Inula helenium Ethanolic Extracts. · Molecules (Basel, Switzerland)
15.PMID: 39042854 (2024) — Inula helenium extract and lidocaine-loaded electrospun wound dressings for managing skin wounds pain and their healing: An in vitro and in vivo study. · Journal of biomaterials applications
16.PMID: 30661396 (2020) — Active ingredients of Inula helenium L. exhibits similar anti-cancer effects as isoalantolactone in pancreatic cancer cells. · Natural product research
17.PMID: 24754913 (2014) — The genus Inula and their metabolites: from ethnopharmacological to medicinal uses. · Journal of ethnopharmacology
18.PMID: 24288468 (2013) — Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone. · TheScientificWorldJournal
19.PMID: 34899346 (2021) — Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer. · Frontiers in pharmacology