Quel est le nom anglais de Embauba Amazonian ?

Embauba Amazonian (Cecropia glaziovii) est connu en anglais sous les noms Arbre à trompettes, Yagrumo, Embauba. Il est traditionnellement utilisé pour hypertension, asthme, diabète.

Embauba Amazonian est-il sûr pendant la grossesse ?

Embauba Amazonian n'est pas recommandé pendant la grossesse. Consultez votre professionnel de santé pour des alternatives.

Embauba Amazonian interagit-il avec les médicaments ?

Embauba Amazonian ne présente pas d'interaction médicamenteuse majeure bien documentée dans notre base, mais informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Quels sont les effets secondaires de Embauba Amazonian ?

Contraindicated during pregnancy and lactation due to potential uterine stimulation and lack of safety data.. May cause hypotension when used concurrently with antihypertensive medications; monitor blood pressure regularly.. Gastrointestinal upset (nausea, diarrhea) has been reported with high doses; start with lower doses and titrate slowly.

Comment calculer une dose sûre de Embauba Amazonian ?

Utilisez le calculateur de posologie gratuit d'HerbAlly — saisissez la dose adulte de référence pour Embauba Amazonian, plus l'âge et le poids, pour obtenir une estimation pédiatrique selon Clark / Young. Ne dépassez jamais la dose adulte.

Embauba Amazonian (Cecropia glaziovii): Benefits, Dosage, Safety & Evidence

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Cecropia glaziovii (red embaúba) is a Brazilian medicinal plant used traditionally for treating hypertension, diabetes, and inflammation [PMID:26965365, PMID:32786546].

Contexte

Cecropia glaziovii Snethl, commonly known as embaúba-vermelha, is a tree widely distributed throughout Latin America and the Southeastern Brazilian coast [PMID:22480215, PMID:17446057].

Usages traditionnels

Used in Brazilian folk medicine to treat diabetes, high blood pressure, cough, asthma, bronchitis, and inflammation [PMID:26965365, PMID:22480215, PMID:17446057].

Composés actifs

The plant contains phenolic compounds, specifically C-glycosyl flavonoids (including orientin, isoorientin, vitexin, and isovitexin), procyanidins (B2 and B3), flavanols (catechin, epicatechin), chlorogenic acid, and caffeic acid [PMID:30144200, PMID:34610498, PMID:20837386, PMID:28372908].

Mécanisme d'action

Vasodilatory effects are associated with the mobilization of Ca2+ in endothelial cells and potential blockade of L-type calcium channels in vascular smooth musculature [PMID:34610498, PMID:18462931].

Preuves cliniques

Preuve DHypertension

Standardized aqueous extract induced hypotension in normotensive rats and decreased hypertension in spontaneous hypertensive rats and L-NAME induced models [PMID:17446057]

Preuve DInflammation

Crude aqueous extract demonstrated in vivo anti-inflammatory effects in a pleurisy animal model, reducing proinflammatory cytokines (TNF-α, IL-1β, and IL-6) [PMID:26965365]

Preuve DHepatotoxicity

Hydroethanolic extract (20 mg/kg) showed hepatoprotective effects by inhibiting lipid peroxidation and decreasing serum ALT and AST levels in CCl4-induced models [PMID:22480215]

Preuve DHerpes Simplex Virus (HSV-1/2)

C-glycosylflavonoid-enriched fractions showed in vitro anti-herpes activity by inhibiting virus entry and reducing viral infectivity [PMID:20572924, PMID:22480215]

Preuve DGastric Acid Secretion

Standardized aqueous extract inhibits gastric acid secretion [PMID:18462931]

Interactions médicamenteuses

C. glaziovii extracts showed relevant inhibitory interactions with CYP3A4 and CYP2D6 enzymes in vitro, and significantly increased CYP3A4 reporter fluorescence [PMID:32786546, PMID:30772286].

Synthèse des preuves

The current evidence is based on in vitro studies and animal models (Level D), demonstrating significant potential for antihypertensive, anti-inflammatory, and antiviral activities, though human clinical trials are lacking.

Sources PubMed

1.PMID: 26965365 (2016) — Anti-inflammatory and antioxidant activities of aqueous extract of Cecropia glaziovii leaves. · Journal of ethnopharmacology
2.PMID: 32786546 (2020) — Effects of Standardized Medicinal Plant Extracts on Drug Metabolism Mediated by CYP3A4 and CYP2D6 Enzymes. · Chemical research in toxicology
3.PMID: 18462931 (2008) — Inhibition of gastric acid secretion by a standardized aqueous extract of Cecropia glaziovii Sneth and underlying mechanism. · Phytomedicine : international journal of phytotherapy and phytopharmacology
4.PMID: 22480215 (2012) — Hepatoprotective effects and HSV-1 activity of the hydroethanolic extract of Cecropia glaziovii (embaúba-vermelha) against acyclovir-resistant strain. · Pharmaceutical biology
5.PMID: 34610498 (2021) — The mechanisms of calcium mobilization by procyanidins, flavonols and flavonoids from Cecropia glaziovii Sneth in pulmonary endothelial cell cultures endorse its popular use as vasodilator phytomedicine.

Embauba Amazonian

Sources et citations

Calculer une dose sûre de Embauba Amazonian

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