How does Embelia ribes kill intestinal worms?

Embelia ribes works primarily through its active compound embelin, which exhibits anthelmintic properties. Research suggests embelin inhibits mitochondrial respiration in parasites, disrupting their energy metabolism and causing paralysis or death. This mechanism allows the worms to be expelled from the digestive tract naturally, supporting its traditional Ayurvedic use for parasitic infections.

Does Embelia ribes interact with medications?

There are currently no well-documented clinical drug interactions for Embelia ribes. However, because it can alter gut motility and absorption, it may theoretically affect the bioavailability of oral medications. Patients taking anticoagulants or antidiabetic drugs should consult a healthcare provider before use, as safety data remains limited.

What is the recommended dosage for Embelia ribes?

The standard adult dosage for Embelia ribes fruit powder is 3 to 6 grams daily, often divided into doses. For standardized extracts, a daily intake of approximately 200 mg is common. It is typically taken with warm water. Users should avoid exceeding these amounts to prevent gastric irritation.

Is Embelia ribes safe during pregnancy?

No, Embelia ribes is considered unsafe during pregnancy. The herb possesses emmenagogue and anthelmintic properties that can stimulate uterine contractions, potentially leading to miscarriage. It is strictly contraindicated for pregnant women and should also be avoided by children under six years of age.

What is Embelia ribes used for?

Embelia ribes is primarily used in Ayurvedic medicine to treat intestinal worm infestations. With an evidence level of C, it is supported by preliminary research and tradition. It is also employed for managing constipation, skin diseases, and toothaches due to its mild laxative, antibacterial, and analgesic properties.

What are the side effects of Embelia ribes?

Common side effects of Embelia ribes include mild digestive upset and nausea, particularly if taken on an empty stomach or in excessive doses. Overuse may lead to gastric irritation. It is generally well-tolerated when used within the recommended dosage range of 3 to 6 grams of fruit powder.

Embelia Ribes (Embelia ribes)

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Embelia ribes (Vidanga) is a medicinal plant used in Ayurveda, primarily characterized by its active compound embelin, which exhibits diverse pharmacological activities including anticancer, antidiabetic, and anti-inflammatory effects [PMID:35883850, PMID:27671825].

Contexte

Embelia ribes Burm. (family Myrsinaceae or Primulaceae) is a woody liana/climber distributed throughout India, particularly in the Western Ghats [PMID:36528661, PMID:32943821]. It is recognized as one of the 32 ayurvedic drugs of national importance by the Government of India [PMID:36655531].

Usages traditionnels

In traditional Indian medicine (Ayurveda), it is used to treat tumors, ascites, bronchitis, jaundice, diseases of the heart and brain, and is used for its anthelmintic activity to cure flatulence and colic [PMID:25818695, PMID:12458656].

Composés actifs

The primary bioactive constituent is embelin, a natural para-benzoquinone [PMID:35883850, PMID:27671825]. The plant also contains essential oils, alkaloids, flavonoids, steroids, phenolics, and alkylresorcinols [PMID:35883850, PMID:29723563].

Mécanisme d'action

Embelin acts as a non-peptidic, cell-permeable small inhibitor of the X-linked inhibitor of apoptosis protein (XIAP), preventing its association with caspase-9 to induce apoptosis [PMID:38234968, PMID:24397264, PMID:29620447]. It also modulates signal transduction pathways including NF-κB, PI3Kinase/AKT, and STAT3 [PMID:38234968, PMID:29620447], and may influence the ATF6-mediated P2X7r-NLRP3 signaling pathway in liver disease [PMID:40106966].

Preuves cliniques

Preuve ADiabetes Mellitus

Meta-analysis of 13 experimental rat studies showed ER and embelin significantly reduced blood glucose and glycosylated haemoglobin [PMID:27984799].

Preuve DDyslipidemia in Diabetic Rats

Oral administration of ethanolic extract (200 mg/kg) for 20 days significantly decreased blood glucose, serum total cholesterol, and triglycerides, while increasing HDL-cholesterol [PMID:12458656].

Preuve DAcute Respiratory Distress Syndrome (LPS-induced)

Embelin (5, 10, and 20 mg/kg/day i.p.) attenuated ARDS in murine models [PMID:25818695].

Preuve DAlcohol-associated Liver Disease

Embelin mitigated lipid synthesis and inflammation in mice models via ATF6-mediated pathways [PMID:40106966].

Preuve BContraception

Embelia ribes has been cited as a plant exhibiting pregnancy prevention activity in clinical trials [PMID:8241931].

Preuve CCancer

Sécurité et effets indésirables

Embelin is reported to be non-toxic at low doses [PMID:27671825].

Synthèse des preuves

The evidence is primarily based on in vitro studies, animal models (rats/mice), and literature reviews. There is one meta-analysis supporting antidiabetic effects in animal models and a mention of clinical trials for antifertility activity.

Sources PubMed

1.PMID: 35883850 (2022) — Reviewing the Traditional/Modern Uses, Phytochemistry, Essential Oils/Extracts and Pharmacology of Embelia ribes Burm. · Antioxidants (Basel, Switzerland)
2.PMID: 8241931 (1993) — The quest for a herbal contraceptive. · The National medical journal of India
3.PMID: 27671825 (2016) — Embelin and Its Role in Chronic Diseases. · Advances in experimental medicine and biology
4.PMID: 25818695 (2015) — Embelia ribes ameliorates lipopolysaccharide-induced acute respiratory distress syndrome. · Journal of ethnopharmacology
5.PMID: 40106966 (2025) — Embelin improves alcoholic steatohepatitis in alcohol-associated liver disease via ATF6-mediated P2X7r-NLRP3 signaling pathway.

Embelia Ribes

Sources et citations