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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Euphorbia lathyris
Euphorbia vivace utilisée en médecine populaire européenne et chinoise comme purifiant, et étudiée pour sa teneur en ingenol mebutate dans le traitement du cancer.
Euphorbia lathyris, also known as caper spurge, is a biennial plant historically used in European and Chinese folk medicine as a potent purgative. Modern research focuses on its diterpene ester ingenol mebutate, which is FDA-approved as a topical gel for actinic keratosis and under investigation for other neoplasms. Key active compounds include ingenol mebutate, lathyrol, euphorbol, and various terpenoids, with the latex being highly toxic due to irritant and co-carcinogenic properties.
Ingenol mebutate acts as a protein kinase C (PKC) activator, inducing rapid cell death via mitochondrial disruption and necrosis in dysplastic keratinocytes, followed by a neutrophil-mediated inflammatory response that clears residual cells. Lathyrol and other diterpenes in the latex are potent irritants that stimulate purgation through intestinal mucosal irritation and increased peristalsis, likely via activation of TRPA1 and TRPV1 receptors. The plant's toxicity is mediated by phorbol esters that activate PKC isoforms, leading to inflammation and tumor promotion in susceptible tissues.
Euphorbia vivace utilisée en médecine populaire européenne et chinoise comme purifiant, et étudiée pour sa teneur en ingenol mebutate dans le traitement du cancer.
Euphorbia lathyris, also known as caper spurge, is a biennial plant historically used in European and Chinese folk medicine as a potent purgative. Modern research focuses on its diterpene ester ingenol mebutate, which is FDA-approved as a topical gel for actinic keratosis and under investigation for other neoplasms. Key active compounds include ingenol mebutate, lathyrol, euphorbol, and various terpenoids, with the latex being highly toxic due to irritant and co-carcinogenic properties.
Ingenol mebutate acts as a protein kinase C (PKC) activator, inducing rapid cell death via mitochondrial disruption and necrosis in dysplastic keratinocytes, followed by a neutrophil-mediated inflammatory response that clears residual cells. Lathyrol and other diterpenes in the latex are potent irritants that stimulate purgation through intestinal mucosal irritation and increased peristalsis, likely via activation of TRPA1 and TRPV1 receptors. The plant's toxicity is mediated by phorbol esters that activate PKC isoforms, leading to inflammation and tumor promotion in susceptible tissues.