Euphorbia prostrata (Euphorbia prostrata): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Euphorbia prostrata work for hemorrhoids?

Euphorbia prostrata works primarily through its tannin and flavonoid content, which provide astringent and anti-inflammatory effects. Tannins help constrict blood vessels and reduce bleeding, while flavonoids support vascular integrity and reduce tissue inflammation. Terpenoids contribute additional wound-healing properties. Together, these compounds help shrink swollen hemorrhoidal tissue, alleviate discomfort, and promote healing of the affected area. Evidence level: C (preliminary research and traditional use).

Is Euphorbia prostrata safe to use during pregnancy?

No, Euphorbia prostrata is considered unsafe during pregnancy and should be avoided. The plant contains latex and active compounds that may stimulate uterine contractions or cause adverse effects on fetal development. Additionally, safety during breastfeeding has not been established. Women who are pregnant, attempting to conceive, or nursing should not use this herb internally or topically without explicit guidance from a qualified healthcare provider. Evidence level: C (traditional contraindication).

What is the recommended dosage for Euphorbia prostrata?

For external use on hemorrhoids or wounds, Euphorbia prostrata is typically applied as a topical poultice as needed throughout the day. For internal use such as diarrhea, traditional preparations suggest 3-5 grams of dried herb brewed as tea, taken twice daily. Standardized dosing guidelines are lacking, and potency varies between preparations. Consult a qualified herbalist or healthcare provider for personalized dosing recommendations. Evidence level: C (traditional use).

Does Euphorbia prostrata interact with any medications?

Limited research exists on specific drug interactions with Euphorbia prostrata. Due to its tannin content, oral preparations may potentially reduce absorption of certain medications if taken simultaneously. Effects on blood clotting are not well studied, so caution is advised when combining with anticoagulant or antiplatelet medications. Always consult a healthcare provider before combining herbal remedies with prescription medications. Evidence level: C (theoretical based on constituent properties).

What are the side effects of Euphorbia prostrata?

The most commonly reported side effects of Euphorbia prostrata include skin irritation, redness, and contact dermatitis, particularly in individuals with latex sensitivity or allergy. The plant's latex can cause allergic reactions ranging from mild irritation to more severe responses in sensitive individuals. Discontinue use if irritation occurs. Internal use may cause gastrointestinal discomfort in some people. Evidence level: C (traditional use and case reports).

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Euphorbia prostrata is an annual herb native to tropical and subtropical Americas, used traditionally for various pathological conditions including hemorrhoids and diabetes [PMID:38348094, PMID:36653685, PMID:36662647].

Contexte

Euphorbia prostrata Aiton is an annual herb in the Euphorbiaceae family, native to the Americas and introduced to regions including Korea [PMID:38348094]. It is closely related to E. humifusa, E. thymifolia, and E. hirta [PMID:38348094].

Usages traditionnels

Traditional uses include treatment of hemorrhoids, inflammation, pain, chronic diseases, and diabetes [PMID:36653685, PMID:36662647, PMID:38545175].

Composés actifs

Phytochemical screening has identified glycosides, phytosterols, flavonoids, polyphenols, tannins, anthraquinones, carbohydrates, saponins, quinines, proteins, and terpenes [PMID:36653685, PMID:38545175].

Mécanisme d'action

In bronchial asthma models, the water-soluble fraction of the alcoholic extract causes relaxation of smooth muscles to relieve bronchial spasms [PMID:22557397]. In inflammatory models, it may selectively inhibit histamine-induced edema, suggesting suppression of the first phase of acute inflammatory reactions [PMID:2615426].

Preuves cliniques

Preuve DHemorrhoids during pregnancy

Oral tablets (100 mg) and topical cream (1% w/w) significantly reduced per-rectal bleeding and pain at defecation [PMID:38496090]

Preuve DSymptomatic hemorrhoids (Grade I and II)

One tablet consumed on an empty stomach every morning for two weeks showed effectiveness in early grades of symptomatic hemorrhoids [PMID:21434487]

Preuve DDiabetes (Hyperglycemia)

Ethanolic plant extract (250-500 mg/kg) showed concentration-dependent mild to moderate reduction (5.2% to 10.0%) in blood glucose in alloxan-induced diabetic rats [PMID:36662647]; also significantly decreased hyperglycemic peaks in rabbits [PMID:9683340]

Preuve DAcute Inflammation

Oral dose (200 mg/kg) of ethyl acetate fraction inhibited 76% of acute carrageenan-induced paw edema in rats [PMID:2615426]; topical application also showed significant anti-inflammatory activity in mice [PMID:2214815]

Preuve DGastric Ulcers

Extract significantly decreased gastric volume, total acid output, ulcer score, and ulcer index in aspirin-induced gastric ulcers in rabbits [PMID:30772784]

Sécurité et effets indésirables

A prospective study on pregnant women using E. prostrata tablets and cream assessed adverse events, though specific adverse effects were not detailed in the abstract [PMID:38496090].

Grossesse et allaitement

A prospective multicenter study evaluated the efficacy and safety of E. prostrata tablets (100 mg) and cream (1% w/w) for the management of hemorrhoids during pregnancy [PMID:38496090].

Interactions médicamenteuses

In alloxanized rats, ethanolic plant extract (EPE) was administered concomitantly with metformin, glibenclemide, and gliclazide, and blood glucose levels declined significantly [PMID:36662647].

Synthèse des preuves

The evidence consists primarily of animal models (rats, rabbits, mice) and small-scale, non-randomized human prospective or retrospective studies, indicating a low to moderate overall strength of clinical evidence.

Sources PubMed

1.PMID: 38348094 (2024) — The complete chloroplast genome of Euphorbia prostrata (Euphorbiaceae). · Mitochondrial DNA. Part B, Resources
2.PMID: 36653685 (2024) — Medicinal Effects, Phytochemistry, Pharmacology of Euphorbia prostrata and Promising Molecular Mechanisms. · Chinese journal of integrative medicine
3.PMID: 36662647 (2023) — Crude extract from Euphorbia prostrata extended curative period of glibenclemide in alloxan-induced diabetic rats. · Journal of complementary & integrative medicine
4.PMID: 2615426 (1989) — Anti-inflammatory studies on Euphorbia prostrata. · Journal of ethnopharmacology
5.PMID: 38545175 (2024) — Phytochemical screening, antioxidant, immunomodulatory and analgesic potential of aqueous-ethanolic extracts of Euphorbia prostrata ait. and Crotalaria burhia Buch-Ham.

Euphorbia prostrata

Sources et citations

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