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Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Ficus exasperata, also known as sandpaper leaf, is an Afro-tropical tree used in traditional medicine for managing hypertension, diabetes, and inflammatory conditions [PMID: 29286840, 29288758, 35655487].
Contexte
Ficus exasperata Vahl (Moraceae), commonly known as sandpaper, is a terrestrial Afro-tropical tree [PMID: 29288758].
Usages traditionnels
It is used in folk medicine to manage high blood pressure [PMID: 29286840], treat cardiovascular diseases [PMID: 25267581], and manage diabetes, fever, and stress-related disorders [PMID: 35655487]. In Nigeria, it is used as poultices for swellings, wounds, and arthritic joints, and to mitigate itching or inflammation [PMID: 23098056], as well as in ethnoveterinary medicine for treating worm infestations [PMID: 23153212]. It is also used by traditional healers in Southern Nigeria to avoid preterm births [PMID: 21796936].
Composés actifs
The plant contains phenolic compounds, including cinnamoyl derivatives, flavonoid-O-glycosides, flavonoid-mono-C-glycosides, flavonoid-di-C-glycosides, and furanocoumarins [PMID: 29288758]. Other identified constituents include saponins, steroids, glycosides [PMID: 35655487], terpenoids, alcohols, and carbonyl compounds [PMID: 15182838]. Specific compounds identified include Chelesta-8,24-dien-3-ol [PMID: 41501348], Ficusamide (a new sphingolipid), and furanocoumarins such as oxypeucedanin hydrate and bergapten [PMID: 22863713].
Mécanisme d'action
Ficus exasperata exhibits antihypertensive activity by inhibiting angiotensin-I converting enzyme (ACE) [PMID: 25267581, 29286840]. It demonstrates antioxidant and anti-inflammatory effects by suppressing LPS-induced expression of mediators such as interleukin-1β, tumor necrosis factor-α (TNF-α), and inducible nitric oxide (iNO) in macrophages [PMID: 23098056], and by attenuating NF-κB signaling in hepatic damage [PMID: 35655487]. In diabetic models, it affects the expression of BDNF, tau, ACHE, and BACE [PMID: 39691470].
Preuves cliniques
Preuve DHypertension
Aqueous leaf extract showed hypotensive effects in rat models [PMID: 22468006, 18323249] and inhibited ACE activity in high cholesterol diet fed rats [PMID: 25267581].
Preuve DDiabetes Mellitus
Leaf aqueous extract demonstrated hypoglycaemic effects in type 1 and type 2 diabetic rat models [PMID: 22468006] and provided reno-protective effects against streptozotocin-induced damage [PMID: 2253217도].
Preuve DInflammation/Arthritis
Ethanolic leaf extract significantly reduced arthritic edema in Freund's adjuvant-induced arthritis rat models [PMID: 21808547]. Methanol/methylene chloride extract inhibited acute and chronic inflammation in rodent paws [PMID: 23098056].
Preuve DGastric Ulcers
Aqueous leaf extracts reduced the ulcer index and gastric volume in indomethacin-induced gastric ulcer rats [PMID: 25815713, 28962358].
Preuve DHepatotoxicity
Ethanolic extract attenuated acetaminophen-induced hepatic damage via the NF-κB signaling mechanism in rats [PMID: 35655487].
Preuve D
Sécurité et effets indésirables
Acute toxicity tests in mice using ethanol extracts up to 1000 mg/kg did not report significant mortality [PMID: 23153212].
Grossesse et allaitement
Used traditionally in Southern Nigeria to avoid preterm births [PMID: 21796936]; however, specific safety data for pregnancy and lactation are not provided in the abstracts.
Synthèse des preuves
The evidence is based entirely on in vitro studies and animal models (rats, mice, flies, and chickens), indicating a low overall strength of clinical evidence (Level D) for human use.
Sources PubMed
1.PMID: 39691470 (2024) — Effects of Ficus exasperata on neurotransmission and expression of BDNF, tau, ACHE and BACE in diabetic rats. · Metabolism open
2.PMID: 25267581 (2014) — Phenolic compounds from sandpaper (ficus exasperata) leaf inhibits angiotensin 1 converting enzyme in high cholesterol diet fed rats. · Journal of ethnopharmacology
3.PMID: 29286840 (2018) — Effect of Different Processing Methods on Antihypertensive Property and Antioxidant Activity of Sandpaper Leaf (Ficus exasperata) Extracts. · Journal of dietary supplements
4.PMID: 39144917 (2024) — Elucidation and active ingredient identification of aqueous extract of Ficus exasperata Vahl leaf against bisphenol A-induced toxicity through in vivo and in silico assessments. · In silico pharmacology
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Saponin fraction of leaf extract attenuated motor deficits in vanadium-induced parkinsonism mice [PMID: 32647086].
Preuve DHelminthiasis (Veterinary)
Ethanol extracts caused 100% larval mortality of Heligmosomoides bakeri in vitro [PMID: 23153212].
(2011)
— Hypoglycaemic and hypotensive effects of Ficus exasperata vahl. (Moraceae) leaf aqueous extract in rats.
· African journal of traditional, complementary, and alternative medicines : AJTCAM
6.PMID: 23153212 (2013) — Anthelmintic potential of three plants used in Nigerian ethnoveterinary medicine. · Pharmaceutical biology
7.PMID: 25815713 (2016) — Indomethacin-induced gastric ulceration in rats: Ameliorative roles of Spondias mombin and Ficus exasperata. · Pharmaceutical biology
8.PMID: 29288758 (2018) — Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark. · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
9.PMID: 15182838 (2004) — Stabilization of palm oils by using Ficus exasperata leaves in local processing methods. · Bioresource technology
11.PMID: 40353243 (2025) — Molecular basis of cardioprotective effects of methanol extract of Ficus exasperata in diabetic Wistar rats. · Toxicology reports
12.PMID: 35655487 (2022) — Ficus exasperata Attenuates Acetaminophen-Induced Hepatic Damage via NF-κB Signaling Mechanism in Experimental Rat Model. · BioMed research international
13.PMID: 21808547 (2010) — Antiarthritic and antioxidant effects of the leaf extract of Ficus exasperata P. Beauv. (Moraceae). · Pharmacognosy research
14.PMID: 34693556 (2022) — Fig (Ficus exasperata and Ficus asperifolia)-Supplemented diet improves sexual function, endothelial nitric oxide synthase and suppresses tumour necrosis factor-alpha genes in hypertensive rats. · Andrologia
15.PMID: 24511752 (2013) — Diuretic effects of aqueous extract of Ficus exasperata Vahl. leaves in rat. · Pakistan journal of biological sciences : PJBS
16.PMID: 28962358 (2015) — Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata. · Toxicology reports
17.PMID: 23266275 (2013) — The leaves of Ficus exasperata Vahl (Moraceae) generates uterine active chemical constituents. · Journal of ethnopharmacology
18.PMID: 23098056 (2013) — Extracts of Ficus exasperata leaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expression of mediators of inflammation in macrophages. · Journal of immunotoxicology
19.PMID: 28092975 (2017) — Characterisation of the antiproliferative constituents and activity of Ficus exasperata (Vahl) on ovarian cancer cells -a preliminary investigation. · Natural product research
20.PMID: 25183137 (2014) — In vitro studies to assess the antioxidative, radical scavenging and arginase inhibitory potentials of extracts from Artocarpus altilis, Ficus exasperate and Kigelia africana. · Asian Pacific journal of tropical biomedicine
21.PMID: 22863713 (2012) — A new sphingolipid and furanocoumarins with antimicrobial activity from Ficus exasperata. · Chemical & pharmaceutical bulletin
22.PMID: 25371569 (2014) — Antioxidant and antibacterial activities of flavonoid glycosides from Ficus exasperata Vahl-Holl (moraceae) leaves. · African journal of traditional, complementary, and alternative medicines : AJTCAM
23.PMID: 40664819 (2025) — Bioremediation of potentially toxic metals (PTMs) from dumpsite soils using the composts of Jatropha curcas and Ficus exasperata. · Environmental monitoring and assessment
24.PMID: 30535533 (2019) — Determination of Heavy Metal Concentrations and Their Potential Sources in Selected Plants: Xanthium strumarium L. (Asteraceae), Ficus exasperata Vahl (Moraceae), Persicaria attenuata (R.Br) Sojak (Polygonaceae), and Kanahia laniflora (Forssk.) R.Br. (Asclepiadaceae) from Awash River Basin, Ethiopia. · Biological trace element research
25.PMID: 21796936 (2011) — Oxytocin inhibiting effect of the aqueous leaf extract of Ficus exasperata (Moraceae) on the isolated rat uterus. · Acta poloniae pharmaceutica
26.PMID: 18323249 (2007) — Pharmacognosy and hypotensive evaluation of Ficus exasperata Vahl (Moraceae) leaf. · Acta poloniae pharmaceutica
27.PMID: 22532177 (2012) — Effects of Ficus exasperata vahl. (moraceae) leaf aqueous extract on the renal function of streptozotocin-treated rats. · Folia morphologica
28.PMID: 41501348 (2026) — Chelesta-8,24-dien-3-ol in Ficus exasperata leaves enhances the prevention of sodium nitrite-induced hypoxia by binding to HIF-1 and NF-κB. · Scientific reports
29.PMID: 36441345 (2022) — The impact of breed, Ficus exasperata leaf powder and vitamin C on carcass traits, brain and meat oxidative enzymes of broiler chickens raised under the tropical condition. · Tropical animal health and production