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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Frangula purshiana
Deciduous tree of the Pacific Northwest used by Indigenous peoples and in botanical medicine as a laxative, one of the gentlest stimulant laxatives in traditional use.
Frangula purshiana (Cascara sagrada) is a deciduous tree native to the Pacific Northwest, whose aged bark is used as a gentle stimulant laxative. Its primary active compounds, cascarosides A-D, are anthraquinone glycosides that are converted by gut bacteria into active aglycones such as aloe-emodin and chrysophanol. It is traditionally employed for constipation, liver congestion, and gallbladder disorders, and is considered one of the mildest stimulant laxatives in botanical medicine.
Cascarosides are hydrolyzed by colonic bacteria to active anthraquinones (e.g., emodin, chrysophanol), which stimulate the enteric nervous system, increasing colonic peristalsis and reducing water and electrolyte absorption. This action is mediated through inhibition of Na+/K+-ATPase and activation of chloride secretion, leading to laxation within 6–12 hours. Additionally, the herb exhibits a mild cholagogue effect by promoting bile flow, likely due to its bitter principles and anthraquinone content.
Deciduous tree of the Pacific Northwest used by Indigenous peoples and in botanical medicine as a laxative, one of the gentlest stimulant laxatives in traditional use.
Frangula purshiana (Cascara sagrada) is a deciduous tree native to the Pacific Northwest, whose aged bark is used as a gentle stimulant laxative. Its primary active compounds, cascarosides A-D, are anthraquinone glycosides that are converted by gut bacteria into active aglycones such as aloe-emodin and chrysophanol. It is traditionally employed for constipation, liver congestion, and gallbladder disorders, and is considered one of the mildest stimulant laxatives in botanical medicine.
Cascarosides are hydrolyzed by colonic bacteria to active anthraquinones (e.g., emodin, chrysophanol), which stimulate the enteric nervous system, increasing colonic peristalsis and reducing water and electrolyte absorption. This action is mediated through inhibition of Na+/K+-ATPase and activation of chloride secretion, leading to laxation within 6–12 hours. Additionally, the herb exhibits a mild cholagogue effect by promoting bile flow, likely due to its bitter principles and anthraquinone content.