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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Gelsemium sempervirens
Southeastern US vine; small doses historically used for neuralgia; extremely toxic.
Gelsemium sempervirens (yellow jessamine) is a highly toxic climbing plant historically used for neuralgia, migraine, and febrile conditions. Its primary active alkaloids—gelsemine, sempervirine, and gelsevirine—exert potent CNS and respiratory depressant effects. Due to extreme toxicity and narrow therapeutic index, modern use is restricted to homeopathic dilutions; any internal use of crude plant material is contraindicated.
Gelsemine acts as a competitive antagonist at glycine receptors (GlyR) and also blocks nicotinic acetylcholine receptors (nAChRs), leading to muscle relaxation and respiratory depression. Sempervirine inhibits monoamine oxidase (MAO) and modulates serotonin (5-HT) receptors, contributing to anxiolytic and analgesic effects in ultra-low doses. Gelsevirine and koumine interact with GABA_A receptors and voltage-gated sodium channels, potentiating sedative and antinociceptive actions. The combined alkaloid profile produces a narrow therapeutic window with risk of paralysis and respiratory failure at doses only slightly above the therapeutic range.
Southeastern US vine; small doses historically used for neuralgia; extremely toxic.
Gelsemium sempervirens (yellow jessamine) is a highly toxic climbing plant historically used for neuralgia, migraine, and febrile conditions. Its primary active alkaloids—gelsemine, sempervirine, and gelsevirine—exert potent CNS and respiratory depressant effects. Due to extreme toxicity and narrow therapeutic index, modern use is restricted to homeopathic dilutions; any internal use of crude plant material is contraindicated.
Gelsemine acts as a competitive antagonist at glycine receptors (GlyR) and also blocks nicotinic acetylcholine receptors (nAChRs), leading to muscle relaxation and respiratory depression. Sempervirine inhibits monoamine oxidase (MAO) and modulates serotonin (5-HT) receptors, contributing to anxiolytic and analgesic effects in ultra-low doses. Gelsevirine and koumine interact with GABA_A receptors and voltage-gated sodium channels, potentiating sedative and antinociceptive actions. The combined alkaloid profile produces a narrow therapeutic window with risk of paralysis and respiratory failure at doses only slightly above the therapeutic range.