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Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
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Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Teucrium chamaedrys
A European herb once popular for gout and weight loss, now known to cause hepatotoxicity — a cautionary tale.
Germander (Teucrium chamaedrys) is a traditional European herb historically used for gout, fever, and weight loss, but its use has been largely abandoned due to severe hepatotoxicity. The primary active compounds are neoclerodane diterpenoids such as teucrin A, which are responsible for both the purported effects and the dose-dependent liver injury.
The hepatotoxicity of germander is primarily attributed to neoclerodane diterpenoids (e.g., teucrin A) that undergo metabolic activation by cytochrome P450 enzymes (CYP3A4) to form reactive epoxides. These metabolites deplete glutathione, form protein adducts, and induce mitochondrial permeability transition, leading to apoptosis and necrosis of hepatocytes. Additionally, germander may inhibit bile acid transporters, contributing to cholestatic injury. The traditional anti-inflammatory and diuretic effects are likely due to flavonoids and tannins, but these are overshadowed by the toxic potential.
A European herb once popular for gout and weight loss, now known to cause hepatotoxicity — a cautionary tale.
Germander (Teucrium chamaedrys) is a traditional European herb historically used for gout, fever, and weight loss, but its use has been largely abandoned due to severe hepatotoxicity. The primary active compounds are neoclerodane diterpenoids such as teucrin A, which are responsible for both the purported effects and the dose-dependent liver injury.
The hepatotoxicity of germander is primarily attributed to neoclerodane diterpenoids (e.g., teucrin A) that undergo metabolic activation by cytochrome P450 enzymes (CYP3A4) to form reactive epoxides. These metabolites deplete glutathione, form protein adducts, and induce mitochondrial permeability transition, leading to apoptosis and necrosis of hepatocytes. Additionally, germander may inhibit bile acid transporters, contributing to cholestatic injury. The traditional anti-inflammatory and diuretic effects are likely due to flavonoids and tannins, but these are overshadowed by the toxic potential.