Hai Feng Teng (Piper kadsura): Benefits, Dosage, Safety & Evidence

Questions fréquentes

How does Hai Feng Teng work for joint pain?

Hai Feng Teng (Piper kadsura) contains active compounds including lignans, piperine, kadsurene, and flavonoids that contribute to its therapeutic effects. These compounds exhibit anti-inflammatory and analgesic properties by modulating inflammatory pathways and reducing pro-inflammatory mediators. In Traditional Chinese Medicine theory, it warms the meridians, dispels wind-damp, and unblocks collaterals, making it particularly effective for cold-type joint pain and rheumatoid arthritis. Evidence level: C.

Does Hai Feng Teng interact with any medications?

Hai Feng Teng contains piperine, which may affect how the liver metabolizes certain medications by influencing cytochrome P450 enzymes. This could potentially alter the effectiveness or increase side effects of drugs processed through these pathways. Patients taking blood thinners, anti-platelet medications, or drugs metabolized by CYP450 enzymes should consult a healthcare provider before use. Additionally, due to its warming properties, it may counteract cooling or anti-inflammatory medications used for heat-pattern conditions. Evidence level: C.

What is the recommended dosage of Hai Feng Teng?

The typical adult dosage of Hai Feng Teng is 6-12 grams as a decoction when prepared as a traditional herbal tea. For standardized extracts, 400mg taken twice daily is commonly recommended. Dosage may vary based on individual constitution, severity of symptoms, and whether it is used alone or in combination with other herbs. Always follow guidance from a qualified TCM practitioner or healthcare provider, as improper dosing may lead to gastrointestinal discomfort or mild dizziness. Evidence level: Traditional.

Is Hai Feng Teng safe during pregnancy?

Hai Feng Teng is considered unsafe during pregnancy and should be avoided. As a warming herb that promotes blood circulation and unblocks collaterals, it may stimulate uterine contractions or affect fetal development. Women who are pregnant, trying to conceive, or breastfeeding should not use this herb. Additionally, individuals with heat-pattern inflammation should avoid it, as its warming properties may exacerbate such conditions. Always consult a qualified healthcare provider before using any herbal medicine during pregnancy. Evidence level: Traditional.

What conditions does Hai Feng Teng treat in TCM?

Hai Feng Teng is primarily used in Traditional Chinese Medicine to treat wind-cold-damp joint obstruction, rheumatoid arthritis, muscle spasms, and stiffness. It is particularly effective for cold-type joint pain characterized by discomfort that worsens with cold and improves with warmth. The herb warms the meridians, dispels wind-damp, and unblocks collaterals, making it valuable for conditions involving cold and dampness patterns. It also provides anti-inflammatory and analgesic benefits for joint discomfort. Evidence level: C.

Fiche d'information compilée à partir de PubMed

Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.

Compilé à partir de 30 articles PubMed · modèle : gemma4:31b

Résumé

Hai Feng Teng (Piper kadsura) is a traditional East Asian woody vine used primarily for its anti-inflammatory and antioxidant properties [PMID:40576700, PMID:40505754].

Contexte

Piper kadsura (Choisy) Ohwi, also known as Haifengteng, is a woody vine endemic to East Asia [PMID:26260180, PMID:40505754].

Usages traditionnels

It has over 2000 years of ethnomedicinal use in East Asia for dispelling rheumatism, dredging meridians, alleviating arthralgia, treating asthma, and addressing digestive problems [PMID:40505754, PMID:39578962].

Composés actifs

The herb contains over 208 compounds, including neolignans (e.g., piperkadsin A, B, and C, futoquinol, galgravin, kadsurenin F, kadsurenone), alkaloids (e.g., piperlactam S, amide alkaloids), phenylpropanoids, terpenoids, steroids, and flavonoids [PMID:16724856, PMID:40505754, PMID:38068895, PMID:39578962, PMID:12567271].

Mécanisme d'action

Mechanisms include inhibition of PMA-induced ROS production [PMID:16724856], suppression of NF-κB activation and downregulation of proinflammatory molecules (TNF-α, IL-6, iNOS, COX-2) [PMID:38068895], activation of the SIRT1/PPARγ/GLUT1 axis to restore glycolysis and reduce oxidative stress [PMID:40576700], and modulation of the TREM2/Syk/PI3K/AKT/mTOR signaling pathway to increase Aβ1-42 phagocytosis in microglia [PMID:40424233]. Some components also act as platelet-activating factor (PAF) antagonists [PMID:8237383, PMID:19111511].

Preuves cliniques

Preuve DInflammation/Rheumatism

Extracts and isolated neolignans demonstrate significant anti-inflammatory activity in vitro by inhibiting NO production and key inflammatory enzymes [PMID:12576203, PMID:38623908, PMID:19900811].

Preuve DAlzheimer's Disease (AD) / Neurotoxicity

Piper kadsura extract and components (Hancinone, Futoquinol) improved cell viability, restored glycolysis, and reduced neuronal damage in Aβ25-35-induced mouse models and cell lines [PMID:40576700, PMID:38330236, PMID:35933005].

Preuve DEndotoxemia/Sepsis

Galgravin isolated from P. kadsura ameliorated LPS-induced endotoxemia in mice by suppressing proinflammatory cytokines in the lungs and serum [PMID:38068895].

Preuve DOxidative Stress

Extracts protected human SW1353 cells against H2O2-induced apoptosis by upregulating antioxidant enzymes (SOD-2, GPx, CAT) [PMID:34684868].

Interactions médicamenteuses

Kadsurenone's hepatobiliary excretion was studied in relation to P-glycoprotein (P-gp) and cyclosporin A in rats [PMID:19111511].

Synthèse des preuves

The current evidence is primarily based on in vitro cellular assays and in vivo animal models (Level D), demonstrating potent anti-inflammatory, antioxidant, and neuroprotective effects.

Sources PubMed

1.PMID: 16724856 (2006) — Anti-inflammatory neolignans from Piper kadsura. · Journal of natural products
2.PMID: 40576700 (2025) — Piper Kadsura Extract and its Bioactive Components Attenuates Aβ25-35-Induced Neurotoxicity by Modulating Glycolysis and Activating the SIRT1/PPARγ/GLUT1 Axis. · Neurochemical research
3.PMID: 40424233 (2025) — Hancinone possesses potentials on increasing the ability of HMC3 cells to phagocytosis of Aβ1-42 via TREM2/Syk/PI3K/AKT/mTOR signaling pathway. · PloS one
4.PMID: 26260180 (2016) — The complete plastid genome of Piper kadsura (Piperaceae), an East Asian woody vine. · Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis
5.PMID: 38068895 (2023) — Galgravin Isolated from Piper kadsura Ameliorates Lipopolysaccharide (LPS)-Induced Endotoxemia in Mice.

Hai Feng Teng

Sources et citations

Calculer une dose sûre de Hai Feng Teng

Ribes nigrum

Kunzea Ambigua

Zatoun

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales

Hai Feng Teng

Sources et citations

Calculer une dose sûre de Hai Feng Teng

Plantes associées

Ribes nigrum

Kunzea Ambigua

Zatoun

Questions fréquentes

Résumé

Contexte

Usages traditionnels

Composés actifs

Mécanisme d'action

Preuves cliniques

Interactions médicamenteuses

Synthèse des preuves

Sources PubMed

Sources gouvernementales