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DH
Not CommonVérifié
Digestif Haritaki
Terminalia chebula
Régulation intestinale et tonique digestif en Ayurveda
Cette fiche a été compilée à partir de résumés PubMed (NIH) avec l'assistance d'une IA. Chaque affirmation factuelle est citée par un article PubMed réel (voir la liste des sources). Elle n'a pas encore été révisée par un humain — confirmez auprès d'un professionnel de santé avant utilisation.
Compilé à partir de 30 articles PubMed · modèle : gemma4:31b
Résumé
Terminalia chebula, commonly known as Haritaki or Myrobalan, is a traditional medicinal plant used across various indigenous systems for its diverse pharmacological activities, including antioxidant and anti-inflammatory effects [PMID:36051270, PMID:28871682].
Contexte
Terminalia chebula Retz. (Family: Combretaceae) is a tree widely distributed in India and is highly valued in Tibetan, Unani, Tibb, Ayurveda, and Siddha medicine [PMID:24501534, PMID:36051270]. It is often referred to as the 'king' of Mongolian and Tibetan medicines [PMID:28871682].
Usages traditionnels
Traditionally used to treat ailments such as bleeding, carminative issues, dysentery, liver dysfunction, digestive disorders, diarrhea, analgesic needs, anthelmintic requirements, skin disorders [PMID:36051270], constipation, and diabetes [PMID:27400482]. Folklore uses also include asthma, sore throat, vomiting, hiccough, bleeding piles, ulcers, gout, and heart and bladder diseases [PMID:23620847].
Composés actifs
Main chemical components include triterpene acid, galloyl glucose, anthraquinonoid [PMID:28871682], chebulinic acid [PMID:37605424], chebulic acid [PMID:30956868], flavonoids, tannins, and phenolic acids [PMID:32307775].
Mécanisme d'action
Mechanisms include the regulation of anti-inflammatory factors and suppression of STAT1/3 and NF-κB signaling [PMID:35830757], modulation of Nrf2 and its related enzymes to provide hepatoprotection [PMID:30956868], and inhibition of xanthine oxidase, the uric acid transporter, and NLRP3 inflammasome activation in gout [PMID:40268110]. It also inhibits the TLR4/MyD88/NF-κB axis in hyperuricemic nephropathy [PMID:38159820].
Preuves cliniques
Preuve DGastrointestinal Transit
Both Churna and Vati dosage forms significantly shortened intestinal transit time in mice, with Churna being more effective [PMID:23723658].
Preuve DHyperlipidemia/Atherosclerosis
Reduced total cholesterol, triglycerides, and aortic sudanophilia in rabbits and rats [PMID:3225068, PMID:22247850, PMID:22557135].
Preuve DAtopic Dermatitis
Extract ameliorated symptoms in a mouse model by regulating anti-inflammatory factors [PMID:35830757].
Preuve DGout Arthritis
Relieved gout arthritis in rats by inhibiting xanthine oxidase and NLRP3 inflammasome [PMID:40268110].
Preuve DH. pylori Infection
Water extracts showed significant antibacterial activity and inhibited urease activity of H. pylori [PMID:11463533].
Interactions médicamenteuses
Terminalia chebula has been shown to improve the pharmacologic effects of phenytoin [PMID:37537774].
Synthèse des preuves
The evidence is primarily based on in vitro studies and animal models (Level D), with several comprehensive reviews (Level C) summarizing traditional uses and pharmacological potential. There is a lack of human clinical trial data in the provided abstracts.
Sources PubMed
1.PMID: 35830757 (2022) — Terminalia chebula Retz. extract ameliorates the symptoms of atopic dermatitis by regulating anti-inflammatory factors in vivo and suppressing STAT1/3 and NF-ĸB signaling in vitro. · Phytomedicine : international journal of phytotherapy and phytopharmacology
2.PMID: 28871682 (2016) — [Pharmacological activity of Terminalia chebula]. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
3.PMID: 24501534 (2013) — Haritaki (Chebulic myrobalan) and its varieties. · Ayu
4.PMID: 36051270 (2022) — A comprehensive review on the diverse pharmacological perspectives of Terminalia chebula Retz. · Heliyon
Aucune monographie gouvernementale directe n'est disponible pour cette plante. Le contenu ci-dessous est généré par IA et n'a pas été vérifié par rapport à une source gouvernementale faisant autorité. Utilisez les liens de recherche pour consulter les sources officielles avant de vous fier à ces informations.
6.PMID: 22557135 (2004) — Hypocholesterolemic effect of Terminalia chebula fruit (Myrobalan) in mice. · Ancient science of life
7.PMID: 27400482 (2016) — Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine. · Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
8.PMID: 30956868 (2019) — Protective effects of chebulic acid from Terminalia chebula Retz. against t-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells. · Food science and biotechnology
9.PMID: 22247850 (2010) — Hypolipidemic activity of haritaki (terminalia chebula) in atherogenic diet induced hyperlipidemic rats. · Journal of advanced pharmaceutical technology & research
10.PMID: 37537774 (2023) — Phenytoin's Pharmacological Interactions with Medicinal Herbs: A Review. · Die Pharmazie
11.PMID: 40268110 (2025) — Terminalia chebula Retz. extract relieves gout arthritis by inhibiting xanthine oxidase, the uric acid transporter, and NLRP3 inflammasome activation. · Journal of ethnopharmacology
12.PMID: 11463533 (2001) — Antibacterial activity of black myrobalan (Terminalia chebula Retz) against Helicobacter pylori. · International journal of antimicrobial agents
13.PMID: 23723658 (2012) — A comparative evaluation of intestinal transit time of two dosage forms of Haritaki [Terminalia chebula Retz]. · Ayu
14.PMID: 23620847 (2013) — The development of Terminalia chebula Retz. (Combretaceae) in clinical research. · Asian Pacific journal of tropical biomedicine
15.PMID: 3225068 (1988) — The Ayurvedic medicines Haritaki, Amala and Bahira reduce cholesterol-induced atherosclerosis in rabbits. · International journal of cardiology
16.PMID: 32307775 (2020) — Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities. · Phytotherapy research : PTR
17.PMID: 38159820 (2024) — The Terminalia chebula Retz extract treats hyperuricemic nephropathy by inhibiting TLR4/MyD88/NF-κB axis. · Journal of ethnopharmacology