Loading...
Ce produit n'est pas destiné à diagnostiquer, traiter, guérir ou prévenir toute maladie. Ces déclarations n'ont pas été évaluées par la Food and Drug Administration.
Loading...
Ces informations sont fournies à titre éducatif uniquement et ne remplacent pas un avis médical professionnel, un diagnostic ou un traitement. Consultez toujours votre professionnel de santé avant d'utiliser des plantes, surtout si vous êtes enceinte, allaitez, prenez des médicaments ou avez une condition médicale.
Heracleum mantegazzianum
Invasive European Apiaceae with extremely toxic phototoxic sap causing severe third-degree burns; no medicinal use.
Heracleum mantegazzianum, commonly known as giant hogweed, is an invasive Apiaceae species with no recognized medicinal use due to its highly toxic sap. The sap contains furanocoumarins (bergapten, psoralen, xanthotoxin, imperatorin) that cause severe phototoxic burns, leading to third-degree skin damage upon UV exposure. This monograph serves solely as a toxicological reference.
Furanocoumarins in the sap are linear psoralens that intercalate into DNA and, upon UVA irradiation, form covalent cross-links with pyrimidine bases, inhibiting DNA replication and transcription. This leads to cell death and severe inflammatory responses. Additionally, these compounds inhibit cytochrome P450 enzymes (e.g., CYP3A4) and can cause hepatotoxicity. The phototoxic reaction is mediated by oxidative stress and apoptosis in keratinocytes and fibroblasts.
Invasive European Apiaceae with extremely toxic phototoxic sap causing severe third-degree burns; no medicinal use.
Heracleum mantegazzianum, commonly known as giant hogweed, is an invasive Apiaceae species with no recognized medicinal use due to its highly toxic sap. The sap contains furanocoumarins (bergapten, psoralen, xanthotoxin, imperatorin) that cause severe phototoxic burns, leading to third-degree skin damage upon UV exposure. This monograph serves solely as a toxicological reference.
Furanocoumarins in the sap are linear psoralens that intercalate into DNA and, upon UVA irradiation, form covalent cross-links with pyrimidine bases, inhibiting DNA replication and transcription. This leads to cell death and severe inflammatory responses. Additionally, these compounds inhibit cytochrome P450 enzymes (e.g., CYP3A4) and can cause hepatotoxicity. The phototoxic reaction is mediated by oxidative stress and apoptosis in keratinocytes and fibroblasts.